Postoperative anaemia might be a risk factor for postoperative delirium and prolonged hospital stay: A secondary analysis of a prospective cohort study

Kunz, Julius Valentin; Spies, Claudia; Bichmann, Anna; Sieg, Miriam; Mueller, Anika

doi:10.1371/journal.pone.0229325

Cited by 37 publications

(45 citation statements)

References 47 publications

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“…Post-operative anaemia is often a reflection of pre-operative work-up prior to surgery [1][2][3][4]. In addition.…”

Section: Introductionmentioning

confidence: 99%

“…post-operative anaemia is also determined by co-morbidities of patients prior to surgery of which sepsis is a common example. [2] The prevalence of post-operative anaemia varies based on surgical specialties and the experience of the surgeon; prevalence rates of post-operative anaemia as high as 85.8% has been documented by Kunz et al in elective orthopaedic surgeries [2,5]. Furthermore, post-operative anaemia has closely been linked to increased post-operative morbidity, mortality and increased risk of peri-operative blood transfusion [1][2].…”

Section: Introductionmentioning

confidence: 99%

“…Furthermore, post-operative anaemia has closely been linked to increased post-operative morbidity, mortality and increased risk of peri-operative blood transfusion [1][2]. Anaemia is defined as packed cell volume less than 33% [1][2]. The World Health Organization (WHO) has emphasized that reasonable measures need to be taken to optimize pre-operative patients, using a patient's blood management (PBM) approach [2].…”

Section: Introductionmentioning

confidence: 99%

“…Anaemia is defined as packed cell volume less than 33% [1][2]. The World Health Organization (WHO) has emphasized that reasonable measures need to be taken to optimize pre-operative patients, using a patient's blood management (PBM) approach [2]. The associated modifiable risk factors of anaemia are ignorance, illiteracy andpoverty.…”

Section: Introductionmentioning

confidence: 99%

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Prevalence of post-operative anaemia in surgical patients at the Rivers State University Teaching Hospital

Dgb¹,

S²,

Ke³

et al. 2021

World J. Adv. Res. Rev.

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Background: Post-operative anaemia is often a reflection of pre-operative pre-operative work-up and pre-operative anaemia. In addition. Post-operative anaemia is also determined by co-morbidities of patients prior to surgery. The prevalence of post-operative anaemia varies based on surgical specialties and the experience of the surgeon; prevalence rates as high as 85% have been recorded in orthopaedic surgeries. Aim: To determine the prevalence of post-operative anaemic in surgical patients at the Rivers State University Teaching Hospital (RSUTH). Method: This was a six months cross sectional study of the post-operative anaemia of patients who had operation at the Surgery and Obstetrics/Gyaecology departments of The Rivers State University Teaching Hospital. The permission for the study was granted by the head of department of obstetrics and gynaecology in conjunction with the head of .the hospital management. The yard stick for anaemia was packed cell volume less than 33% in line with the World Health Organization (WHO). A structured proforma was used to obtain information from patient’s case notes and analyzed using SPSS version 25. Result: Three hundred and eigthy subjects were recruited for the study. Males subjects were 150 (39.5%) while females were 230 (60.5%) respectively. The mean age was 31 years. One hundred and ninety nine (52.4%) were obstetrics and gynaecological surgeries while 181 (47.6 %) were non-gynaecological surgeries. The commonest indication for surgery was caesarean section representing 130 (34.2%) of the subjects. Two hundred and sixty six of the subjects (70%) had PCV less than 33%. One hundred and fifty two (40%) women had PCV less than 33% while 114 (30%) of the men had PCV less than 33%. Conclusion: The study revealed that prevalence of post-operative anaemia amongst surgical patients at RSUTH was 70 %. The post-operative anaemia amongst women was worrisome. The need to optimize patients prior to surgery cannot be over-emphasized to prevent morbidities and mortalities post-operative.

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“…Post-operative anaemia is often a reflection of pre-operative work-up prior to surgery [1][2][3][4]. In addition.…”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Prevalence of post-operative anaemia in surgical patients at the Rivers State University Teaching Hospital

Dgb¹,

S²,

Ke³

et al. 2021

World J. Adv. Res. Rev.

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“…Previous studies have shown that preoperative anaemia was considered a risk factor for the outcome in non-cardiac surgery; it was associated with a more extended hospital stay, a higher risk of perioperative complications, and higher mortality [35]. In a recent study of 800 patients undergoing elective noncardiac surgery, anaemia was associated with postoperative delirium and longer hospitalization [36]. The impact of preoperative anaemia on postoperative delirium in the cardiosurgical population is not yet well understood, and the results published so far have often been contradictory.…”

Section: Discussionmentioning

confidence: 99%

Elevated Procalcitonin and Depression As Risk Factors For Postoperative Delirium In The Elderly After Cardiac Surgery – A Prospective Observational Study.

Kupiec

Adamik

Kozera

et al. 2020

Preprint

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Background One of the most common complications after cardiac surgery is delirium. Determining the origin of this complication from possible pathomechanisms is difficult. The activation of an inflammatory response during surgery has been suggested as one possible mechanism of delirium. The usefulness of the inflammatory marker procalcitonin (PCT) as a predictor of delirium after cardiac surgery with cardiopulmonary bypass (CBP) has not yet been investigated. Methods The purpose of this study was to prospectively investigate the risk of developing postoperative delirium in a group of elderly patients using a multivariate assessment of preoperative (PCT, comorbidities, functional decline, depression) and intraoperative risk factors. 149 elderly patients were included. Delirium was assessed using the Confusion Assessment Method for the ICU. Results Thirty patients (20%) developed post-operative delirium: hypoactive in 50%, hyperactive in 33%, mixed in 17%. Preoperative PCT above the reference range (> 0.05 ng/mL) was recorded more often in patients who postoperatively developed delirium than in the non-delirium group (50% vs. 27%, p=0.019). After surgery, PCT was significantly higher in the delirium than the non-delirium group: ICU admission after surgery: 0.08 ng/mL, IQR 0.03-0.15 vs. 0.05 ng/mL, IQR 0.02-0.09, p=0.011), and for consecutive days (day 1: 0.59 ng/mL, IQR 0.25-1.55 vs. 0.25 ng/mL, IQR 0.14-0.54, p=0.003; day 2: 1.21 ng/mL, IQR 0.24-3.29 vs. 0.36 ng/mL, IQR 0.16-0.76, p=0.006; day 3: 0.76 ng/mL, IQR 0.48-2.34 vs. 0.34 ng/mL, IQR 0.14-0.66, p=0.001). Patients with delirium were older (74 years, IQR 70 – 76 vs. 69 years, IQR 67 – 74; p=0.038) and more often had functional decline (47% vs. 28%, p=0.041). There was no difference in comorbidities with the exception of anaemia (43% vs. 19%, p=0.006). Depression was detected in 40% of patients with delirium and in 17% without delirium (p=0.005). In a multivariable logistic regression model of preoperative procalcitonin (OR= 3.05; IQR 1.02-9.19), depression (OR=5.02, IQR 1.67-15.10), age (OR=1.14; IQR 1.02-1.26), functional decline (OR=0.76; IQR 0.63-0.91) along with CPB time (OR=1.04; IQR 1.02-1.06) were significant predictors of postoperative delirium. Conclusion A preoperative PCT test and assessment of functional decline and depression may help identify patients at risk for developing delirium after cardiac surgery.

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Transfusion thresholds for guiding red blood cell transfusion

Carson

Stanworth

Dennis

et al. 2021

Cochrane Database of Systematic Reviews

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Postoperative anaemia might be a risk factor for postoperative delirium and prolonged hospital stay: A secondary analysis of a prospective cohort study

Cited by 37 publications

References 47 publications

Prevalence of post-operative anaemia in surgical patients at the Rivers State University Teaching Hospital

Prevalence of post-operative anaemia in surgical patients at the Rivers State University Teaching Hospital

Elevated Procalcitonin and Depression As Risk Factors For Postoperative Delirium In The Elderly After Cardiac Surgery – A Prospective Observational Study.

Transfusion thresholds for guiding red blood cell transfusion

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