Transfusion thresholds for guiding red blood cell transfusion

Abstract

Transfusion thresholds for guiding red blood cell transfusion.

Transfusion‐related adverse events in patients with restrictive or liberal transfusion strategy. An analysis of the MINT trial

“…There was a total of four cases of anaphylactic transfusion reaction, evenly divided between the two transfusion arms, four cases of acute hemolytic transfusion reaction in the liberal transfusion arm, and one case of transfusion‐associated sepsis in the liberal transfusion arm. These results mirror the safety of transfusion as reported previously 3 . Further, none of these adverse events were confirmed by review of the medical records by transfusion medicine specialists.…”

Transfusion‐related adverse events in patients with restrictive or liberal transfusion strategy. An analysis of the MINT trial

“…There was a total of four cases of anaphylactic transfusion reaction, evenly divided between the two transfusion arms, four cases of acute hemolytic transfusion reaction in the liberal transfusion arm, and one case of transfusion‐associated sepsis in the liberal transfusion arm. These results mirror the safety of transfusion as reported previously 3 . Further, none of these adverse events were confirmed by review of the medical records by transfusion medicine specialists.…”

Patient characteristics and clinical determinants of outpatient red cell transfusions

“…The median pre‐transfusion Hb concentration in our study was 7.5 g/dL and thus in accordance with a widely accepted transfusion trigger of 7–8 g/dL 6,7,12 . Transfusion triggers in the outpatient setting are best investigated for MDS patients, 1,2,17,22 but the optimal trigger is still under debate.…”

“…The median pre‐transfusion Hb concentration in our study was 7.5 g/dL and thus in accordance with a widely accepted transfusion trigger of 7–8 g/dL. 6 , 7 , 12 Transfusion triggers in the outpatient setting are best investigated for MDS patients, 1 , 2 , 17 , 22 but the optimal trigger is still under debate. Our study revealed a substantial inter‐patient and intra‐patient variability of pre‐transfusion Hb levels (Figure 1 , Figures S3 and S4 ) reflecting the variability of RBC transfusion in the outpatient setting.…”

Commentary on “Re-exploration of the optimal threshold for restrictive transfusion after hip fracture: a multicenter prospective cohort”

“…Second, the study reports that a restrictive transfusion threshold (<7 g/dL) did not increase mortality in patients without CVD. This finding is consistent with the results from Cochrane reviews conducted by Carson et al (2021), which suggest that restrictive transfusion strategies are safe for patients with hip fractures, reducing both transfusion rates and associated complications [ 4 ] . However, the authors did not evaluate long-term functional recovery or quality of life, which are crucial outcomes for evaluating transfusion strategies.…”

Transfusion‐related adverse events in patients with restrictive or liberal transfusion strategy. An analysis of the MINT trial

“…There was a total of four cases of anaphylactic transfusion reaction, evenly divided between the two transfusion arms, four cases of acute hemolytic transfusion reaction in the liberal transfusion arm, and one case of transfusion‐associated sepsis in the liberal transfusion arm. These results mirror the safety of transfusion as reported previously 3 . Further, none of these adverse events were confirmed by review of the medical records by transfusion medicine specialists.…”

Patient characteristics and clinical determinants of outpatient red cell transfusions

“…The median pre‐transfusion Hb concentration in our study was 7.5 g/dL and thus in accordance with a widely accepted transfusion trigger of 7–8 g/dL 6,7,12 . Transfusion triggers in the outpatient setting are best investigated for MDS patients, 1,2,17,22 but the optimal trigger is still under debate.…”

“…The median pre‐transfusion Hb concentration in our study was 7.5 g/dL and thus in accordance with a widely accepted transfusion trigger of 7–8 g/dL. 6 , 7 , 12 Transfusion triggers in the outpatient setting are best investigated for MDS patients, 1 , 2 , 17 , 22 but the optimal trigger is still under debate. Our study revealed a substantial inter‐patient and intra‐patient variability of pre‐transfusion Hb levels (Figure 1 , Figures S3 and S4 ) reflecting the variability of RBC transfusion in the outpatient setting.…”

Commentary on “Re-exploration of the optimal threshold for restrictive transfusion after hip fracture: a multicenter prospective cohort”

“…Second, the study reports that a restrictive transfusion threshold (<7 g/dL) did not increase mortality in patients without CVD. This finding is consistent with the results from Cochrane reviews conducted by Carson et al (2021), which suggest that restrictive transfusion strategies are safe for patients with hip fractures, reducing both transfusion rates and associated complications [ 4 ] . However, the authors did not evaluate long-term functional recovery or quality of life, which are crucial outcomes for evaluating transfusion strategies.…”

Transfusion‐related adverse events in patients with restrictive or liberal transfusion strategy. An analysis of the MINT trial

“…There was a total of four cases of anaphylactic transfusion reaction, evenly divided between the two transfusion arms, four cases of acute hemolytic transfusion reaction in the liberal transfusion arm, and one case of transfusion‐associated sepsis in the liberal transfusion arm. These results mirror the safety of transfusion as reported previously 3 . Further, none of these adverse events were confirmed by review of the medical records by transfusion medicine specialists.…”

Patient characteristics and clinical determinants of outpatient red cell transfusions

“…The median pre‐transfusion Hb concentration in our study was 7.5 g/dL and thus in accordance with a widely accepted transfusion trigger of 7–8 g/dL 6,7,12 . Transfusion triggers in the outpatient setting are best investigated for MDS patients, 1,2,17,22 but the optimal trigger is still under debate.…”

“…The median pre‐transfusion Hb concentration in our study was 7.5 g/dL and thus in accordance with a widely accepted transfusion trigger of 7–8 g/dL. 6 , 7 , 12 Transfusion triggers in the outpatient setting are best investigated for MDS patients, 1 , 2 , 17 , 22 but the optimal trigger is still under debate. Our study revealed a substantial inter‐patient and intra‐patient variability of pre‐transfusion Hb levels (Figure 1 , Figures S3 and S4 ) reflecting the variability of RBC transfusion in the outpatient setting.…”

Commentary on “Re-exploration of the optimal threshold for restrictive transfusion after hip fracture: a multicenter prospective cohort”

“…Second, the study reports that a restrictive transfusion threshold (<7 g/dL) did not increase mortality in patients without CVD. This finding is consistent with the results from Cochrane reviews conducted by Carson et al (2021), which suggest that restrictive transfusion strategies are safe for patients with hip fractures, reducing both transfusion rates and associated complications [ 4 ] . However, the authors did not evaluate long-term functional recovery or quality of life, which are crucial outcomes for evaluating transfusion strategies.…”