Postnatal kidney maturation regulates renal artery myogenic constriction

Soni, Hitesh; Buddington, Randal K.; Adebiyi, Adebowale

doi:10.1515/jpm-2013-0346

Cited by 6 publications

(2 citation statements)

References 17 publications

(26 reference statements)

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“…Arteries were monitored with a CCD camera (Sanyo VCB-3512T; Sanyo, Osaka Prefecture, Japan) attached to an inverted microscope (Nikon Eclipse TS100; Nikon, Tokyo, Japan). As routinely done by us [13,15,16,18,22,59] and others [1,4,6,10,34,35,81], the artery external wall diameter (ED) was measured using the automatic edge-detection function of IonWizard software (IonOptics, Westwood, MA) and digitized at 1 Hz. Steady-state changes in intravascular pressure were achieved by elevating an attached reservoir filled with PSS and were monitored using a pressure transducer (Living Systems Instrumentation, St Albans City, VT).…”

Section: Methodsmentioning

confidence: 99%

Differential distribution and functional impact of BK channel beta1 subunits across mesenteric, coronary, and different cerebral arteries of the rat

Kuntamallappanavar

Bisen

Bukiya

et al. 2016

Pflugers Arch - Eur J Physiol

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Large conductance, Ca2+i- and voltage-gated K+ (BK) channels regulate myogenic tone and thus, arterial diameter. In smooth muscle (SM), BK channels include channel-forming α and auxiliary β1 subunits. BK β1 increases the channel’s Ca2+ sensitivity allowing BK channels to negatively feed-back on depolarization-induced Ca2+-entry, oppose SM contraction and favor vasodilation. Thus, endothelial-independent vasodilation can be evoked though targeting of SM BK β1 by endogenous ligands, including lithocholate (LCA). Here, we investigated the expression of BK β1 across arteries of the cerebral and peripheral circulations, and the contribution of such expression to channel function and BK β1–mediated vasodilation. Data demonstrate that endothelium-independent, BK β1-mediated vasodilation by LCA is larger in coronary (CA) and basilar (BA) arteries than in anterior cerebral (ACA), middle cerebral (MCA), posterior cerebral (PCA), and mesenteric (MA) arteries, all arterial segments having a similar diameter. Thus, differential dilation occurs in extracranial arteries which are subjected to similar vascular pressure (CA vs. MA), and in arteries that irrigate different brain regions (BA vs. ACA, MCA, PCA). SM BK channels from BA and CA displayed increased basal activity and LCA responses, indicating increased BK β1 functional presence. Indeed, in the absence of detectable changes in BK α, BA and CA myocytes showed an increased location of BK β1 in the plasmalemma/subplasmalemma. Moreover, these myocytes distinctly showed increased BK β1 mRNA levels. Supporting a major role of enhanced BK β1 transcripts in artery dilation, LCA-induced dilation of MCA transfected with BK β1 cDNA was as high as LCA-induced dilation of untransfected BA or CA.

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Section: Methodsmentioning

confidence: 99%

Differential distribution and functional impact of BK channel beta1 subunits across mesenteric, coronary, and different cerebral arteries of the rat

Kuntamallappanavar

Bisen

Bukiya

et al. 2016

Pflugers Arch - Eur J Physiol

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“…Preterm newborns are at risk of renal insufficiency, whereas fullterm neonates do not yet have mature nephrons and full function. Compared to the arteries of full-term and 4-day-old preterm pigs, the arteries of neonatal preterm pigs (within 24 h) showed greater muscle tone and lower active wall tone (Soni et al, 2015). The development of the heart, kidneys, and renin-angiotensin system (RAS) is essential for maintaining blood pressure.…”

Section: Renal Developmentmentioning

confidence: 99%

Preterm pigs for preterm birth research: reasonably feasible

et al. 2023

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Preterm birth will disrupt the pattern and course of organ development, which may result in morbidity and mortality of newborn infants. Large animal models are crucial resources for developing novel, credible, and effective treatments for preterm infants. This review summarizes the classification, definition, and prevalence of preterm birth, and analyzes the relationship between the predicted animal days and one human year in the most widely used animal models (mice, rats, rabbits, sheep, and pigs) for preterm birth studies. After that, the physiological characteristics of preterm pig models at different gestational ages are described in more detail, including birth weight, body temperature, brain development, cardiovascular system development, respiratory, digestive, and immune system development, kidney development, and blood constituents. Studies on postnatal development and adaptation of preterm pig models of different gestational ages will help to determine the physiological basis for survival and development of very preterm, middle preterm, and late preterm newborns, and will also aid in the study and accurate optimization of feeding conditions, diet- or drug-related interventions for preterm neonates. Finally, this review summarizes several accepted pediatric applications of preterm pig models in nutritional fortification, necrotizing enterocolitis, neonatal encephalopathy and hypothermia intervention, mechanical ventilation, and oxygen therapy for preterm infants.

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Activation of renal vascular smooth muscle TRPV4 channels by 5-hydroxytryptamine impairs kidney function in neonatal pigs

Afolabi

Michael

Falayi

et al. 2023

Microvascular Research

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Postnatal kidney maturation regulates renal artery myogenic constriction

Abstract: Myogenic constriction is elevated in newly born preterm pigs. Our data also suggests that postnatal kidney maturation may modulate renal blood flow autoregulation.

Cited by 6 publications

References 17 publications

Differential distribution and functional impact of BK channel beta1 subunits across mesenteric, coronary, and different cerebral arteries of the rat

Differential distribution and functional impact of BK channel beta1 subunits across mesenteric, coronary, and different cerebral arteries of the rat

Preterm pigs for preterm birth research: reasonably feasible

Activation of renal vascular smooth muscle TRPV4 channels by 5-hydroxytryptamine impairs kidney function in neonatal pigs

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