Activation of renal vascular smooth muscle TRPV4 channels by 5-hydroxytryptamine impairs kidney function in neonatal pigs

Afolabi, Jeremiah; Michael, Olugbenga Samuel; Falayi, Olufunke Olubunmi; Kanthakumar, Praghalathan; Mankuzhy, Pratheesh; Soni, Hitesh; Adebiyi, Adebowale

doi:10.1016/j.mvr.2023.104516

Cited by 3 publications

(1 citation statement)

References 92 publications

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“…92 However, studies have also demonstrated that TRPV4 activation in VSMCs can induce vasoconstriction in some vascular beds. [93][94][95] Recent publications delineated new perspectives on the involvement of VSMC TRPV4 in hypertension. A landmark paper used SMCspecific TRPV4 KO mice to show that TRPV4 channels serve opposing functions in VSMCs by distributing themselves between 2 functionally distinct microdomains: one associated with α1ARs (α1 adrenergic receptors) and the other with large-conductance Ca 2+ -activated K + channels.…”

Section: Trp Channelsmentioning

confidence: 99%

Milestone Papers on Signal Transduction Mechanisms of Hypertension and Its Complications

Eguchi,

Torimoto,

Adebiyi

et al. 2024

Hypertension

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To celebrate 100 years of AHA-supported cardiovascular disease research, this review article highlights milestone papers that have significantly contributed to the current understanding of the signaling mechanisms driving hypertension and associated cardiovascular disorders. This article also includes a few of the future research directions arising from these critical findings. To accomplish this important mission, 4 principal investigators gathered their efforts to cover distinct yet intricately related areas of signaling mechanisms pertaining to the pathogenesis of hypertension. The renin-angiotensin system, canonical and novel contractile and vasodilatory pathways in the resistance vasculature, vascular smooth muscle regulation by membrane channels, and noncanonical regulation of blood pressure and vascular function will be described and discussed as major subjects.

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Section: Trp Channelsmentioning

confidence: 99%

Milestone Papers on Signal Transduction Mechanisms of Hypertension and Its Complications

Eguchi,

Torimoto,

Adebiyi

et al. 2024

Hypertension

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Role of TRPV4 on vascular tone regulation in pathophysiological states

Matsumoto,

Taguchi,

Kobayashi

2023

European Journal of Pharmacology

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Pacemaking in the lymphatic system

Davis,

Zawieja

2024

The Journal of Physiology

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Lymphatic collecting vessels exhibit spontaneous phasic contractions that are critical for lymph propulsion and tissue fluid homeostasis. This rhythmic activity is driven by action potentials conducted across the lymphatic muscle cell (LMC) layer to produce entrained contractions. The contraction frequency of a lymphatic collecting vessel displays exquisite mechanosensitivity, with a dynamic range from <1 to >20 contractions per minute. A myogenic pacemaker mechanism intrinsic to the LMCs was initially postulated to account for pressure‐dependent chronotropy. Further interrogation into the cellular constituents of the lymphatic vessel wall identified non‐muscle cell populations that shared some characteristics with interstitial cells of Cajal, which have pacemaker functions in the gastrointestinal and lower urinary tracts, thus raising the possibility of a non‐muscle cell pacemaker. However, recent genetic knockout studies in mice support LMCs and a myogenic origin of the pacemaker activity. LMCs exhibit stochastic, but pressure‐sensitive, sarcoplasmic reticulum calcium release (puffs and waves) from IP3R1 receptors, which couple to the calcium‐activated chloride channel Anoctamin 1, causing depolarisation. The resulting electrical activity integrates across the highly coupled lymphatic muscle electrical syncytia through connexin 45 to modulate diastolic depolarisation. However, multiple other cation channels may also contribute to the ionic pacemaking cycle. Upon reaching threshold, a voltage‐gated calcium channel‐dependent action potential fires, resulting in a nearly synchronous calcium global calcium flash within the LMC layer to drive an entrained contraction. This review summarizes the key ion channels potentially responsible for the pressure‐dependent chronotropy of lymphatic collecting vessels and various mechanisms of IP3R1 regulation that could contribute to frequency tuning. image

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Activation of renal vascular smooth muscle TRPV4 channels by 5-hydroxytryptamine impairs kidney function in neonatal pigs

Cited by 3 publications

References 92 publications

Milestone Papers on Signal Transduction Mechanisms of Hypertension and Its Complications

Milestone Papers on Signal Transduction Mechanisms of Hypertension and Its Complications

Role of TRPV4 on vascular tone regulation in pathophysiological states

Pacemaking in the lymphatic system

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