Postmortem measurement of caffeine in bone marrow: Influence of sample location and correlation with blood concentration

Cartiser, Nathalie; Bévalot, Fabien; Chatenay, C.; Meur, C. Le; Gaillard, Yvan; Malicier, D.; Guitton, Jérôme; Fanton, Laurent

doi:10.1016/j.forsciint.2011.02.028

Cited by 14 publications

(10 citation statements)

References 28 publications

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“…In previous studies, researchers have investigated the utility of bones in medicolegal investigations of various drugs . The concentrations of some drugs were higher in bone than in blood.…”

Section: Discussionmentioning

confidence: 99%

“…Bone plays a repository role for drugs because many blood vessels are distributed throughout the bone marrow, and bone has a lipid matrix . Previous reports have described the usability of bone to confirm postmortem drug content (e.g., morphine , caffeine , methamphetamine , and nortriptyline ). However, owing to a lack of relevant studies, it is difficult to interpret whether a drug concentration in bone represents therapeutic, toxic, or lethal levels of the drug .…”

mentioning

confidence: 99%

“…Previous reports have described the usability of bone to confirm postmortem drug content (e.g., morphine , caffeine , methamphetamine , and nortriptyline ). However, owing to a lack of relevant studies, it is difficult to interpret whether a drug concentration in bone represents therapeutic, toxic, or lethal levels of the drug . Previous studies have investigated the relationship of drug concentrations between blood and bone .…”

mentioning

confidence: 99%

“…KEYWORDS: forensic science, thighbone, amphetamine, methamphetamine, soil, liquid chromatography-tandem mass spectrometry In medicolegal death investigations, body fluids (blood and urine) and visceral tissues (liver and brain) are widely used for postmortem toxicological investigations (1). However, in the cases of limited, unavailable, or unusable body fluids in bloodless, putrefied, or skeletonized corpses, bone, bone marrow, hair, nail, and tooth could be used for toxicological analyses to determine the causes and circumstances of death (1)(2)(3)(4)(5)(6).…”

mentioning

confidence: 99%

“…However, owing to a lack of relevant studies, it is difficult to interpret whether a drug concentration in bone represents therapeutic, toxic, or lethal levels of the drug . Previous studies have investigated the relationship of drug concentrations between blood and bone . For example, the concentration of pentobarbital in blood shows a positive correlation (correlation coefficient: 0.950) with that in bone until 12 h after death .…”

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confidence: 99%

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Quantification of Methamphetamine in Mouse Thighbones Buried in Soil

Nakao

Tatara

Kibayashi

2017

Journal of Forensic Sciences

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Bone samples are used for analysis of drugs in decomposed or skeletonized bodies. Toxicological analyses of buried bones are important for determining the causes and circumstances of death. In this study, methamphetamine and amphetamine concentrations in heart blood, thigh muscles, and thighbones were analyzed using solid-phase extraction with liquid chromatography-tandem mass spectrometry. Methamphetamine concentrations in heart blood, thigh muscle, and thighbone ranged from 0.041 to 0.873 μg/mL, 0.649 to 2.623 μg/g, and 56.543 to 643.371 μg/g, respectively. Thighbone concentrations were significantly higher than those in heart blood or thigh muscles were. Methamphetamine concentrations in buried thighbone (4.010-45.785 μg/g) were significantly lower than those of unburied thighbones were (56.543-643.371 μg/g). Methamphetamine and amphetamine were detected in thighbones buried for 7-180 days. These findings indicate that the methamphetamine concentrations in bone are higher and decrease after burial in soil.

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Section: Discussionmentioning

confidence: 99%

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confidence: 99%

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confidence: 99%

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confidence: 99%

mentioning

confidence: 99%

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Quantification of Methamphetamine in Mouse Thighbones Buried in Soil

Nakao

Tatara

Kibayashi

2017

Journal of Forensic Sciences

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Using bone marrow matrix to analyze meprobamate for forensic toxicological purposes

et al. 2013

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Bone marrow (BM) analysis is of forensic interest for postmortem toxicological investigations where blood samples are unavailable or unusable. Due to the lack of studies, it remains difficult to interpret concentrations of xenobiotics measured in this matrix. Based on a statistical approach published previously to interpret meprobamate concentrations in bile and vitreous humor, we propose here a diagnostic test for interpretation of BM meprobamate concentrations from analysis of 99 sets of autopsy data. The mean age was 48 years (range 18-80 years, one unknown) for males and 50 years (range 19-80 years, one unknown) for females, with a male/female ratio at 0.768. A BM concentration threshold of 11.3 μg/g was found to be statistically equivalent to that of a blood meprobamate concentration threshold of 50 μg/ml in distinguishing overdose from therapeutic use. The intrinsic qualities of this diagnostic test were good with sensitivity of 0.82 and specificity of 0.92. Compared to previous tests published with the same objective on vitreous humor and bile, this study shows that BM is a useful alternative matrix to reveal meprobamate overdose when blood, vitreous humor, and bile are not available or unusable.

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Analytical Samples

Lappas¹,

Lappas²

2016

Forensic Toxicology

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Postmortem measurement of caffeine in bone marrow: Influence of sample location and correlation with blood concentration

Cited by 14 publications

References 28 publications

Quantification of Methamphetamine in Mouse Thighbones Buried in Soil

Quantification of Methamphetamine in Mouse Thighbones Buried in Soil

Using bone marrow matrix to analyze meprobamate for forensic toxicological purposes

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