Quantification of Methamphetamine in Mouse Thighbones Buried in Soil

Nakao, Kenzo; Tatara, Yuki; Kibayashi, Kazuhiko

doi:10.1111/1556-4029.13458

Cited by 5 publications

(5 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In this study, amphetamine had lower accuracy, recovery rate, and matrix effect values than methamphetamine. In our previously reported study, only the amphetamine recovery rate was low when the bone was used as the matrix [8]. The extraction operation was the same as in the present study.…”

Section: Discussionmentioning

confidence: 69%

“…Previous studies have examined drug concentrations in bones and have shown that they tend to be higher in bones than in blood [8,9,11,23]. One reason why drugs can be present in the bone is due to structural factors.…”

Section: Ta B L E 2 Intra-and Interday Precisionmentioning

confidence: 99%

“…Kojima et al [7] showed that methamphetamine and amphetamine were detected in the femur from a skeletonized corpse buried for 5 years. It has been shown that methamphetamine, amphetamine, cocaine, and their metabolites could be detected in mouse femurs buried in humus for 180 days [8, 9]. The reason why the drug was detected in bones that had been left for a long period of time could be attributed to the structural characteristics of the bones.…”

Section: Introductionmentioning

confidence: 99%

“…

Body fluids and organs are commonly used for toxicological analysis in forensic medicine [1]. However, in cases where stable body fluids and organs cannot be collected due to putrefaction or skeletonization, hard tissues such as bones, hair, and nails may be used for toxicological analysis [1][2][3][4][5][6].Prior research has indicated the usefulness of bone for qualitative and quantitative analysis of drugs such as caffeine, cocaine, methamphetamine, and morphine [2,3,7,8]. Kojima et al [7] showed that methamphetamine and amphetamine were detected in the femur from a skeletonized corpse buried for 5 years.

…”

mentioning

confidence: 99%

“…Prior research has indicated the usefulness of bone for qualitative and quantitative analysis of drugs such as caffeine, cocaine, methamphetamine, and morphine [2,3,7,8]. Kojima et al [7] showed that methamphetamine and amphetamine were detected in the femur from a skeletonized corpse buried for 5 years.…”

mentioning

confidence: 99%

See 4 more Smart Citations

Detection of methamphetamine in mouse femurs exposed to high temperature

Nakao

Kibayashi

2023

Journal of Forensic Sciences

View full text Add to dashboard Cite

Bone samples are valuable for examining the cause of death and circumstance leading up to death when body fluids are not available for forensic toxicological analysis. Examined were heat‐induced changes in methamphetamine and amphetamine concentrations in femurs removed from methamphetamine‐injected mice to determine if the burned bones could be used for toxicology testing. The femurs were heated at 100°C, 300°C, or 500°C for 10 or 30 min. The tissue structure of the heated femurs was preserved at 100°C for 30 min but was destructed at higher temperatures. Methamphetamine and amphetamine were detected in femurs heated at 100°C for 10 min, 100°C for 30 min, and 300°C for 10 min (with methamphetamine and amphetamine concentrations ranging from 0.36 to 35 μg/g and 0.54 to 47 μg/g, respectively). Methamphetamine and amphetamine were detectable when heated above their decomposition temperature as a result of limited heat transfer do to protection provide by the femoral muscle. Thus, the bone could be a useful analytical sample in cases of burn‐related deaths, where it is difficult to collect body fluids.

show abstract

Section: Discussionmentioning

confidence: 69%