2010
DOI: 10.1590/s0102-86502010000200008 View full text |Buy / Rent full text
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Abstract: Purpose:To evaluate the effect of postconditioning protection in liver tissue of rats submitted to ischemia and reperfusion. Methods: 25 Wistar male rats were randomized in three groups: Group A (ischemia and reperfusion -I/R), with 10 rats, which was made ischemia by vascular clamp application in hepatic hilum for 30 minutes and reperfusion for 60 minutes by removal of the clamp; Group B (Postconditioning -IPo), with 10 rats, with same procedure plus postconditioning (3 cycles of reperfusion inserted by 3 cyc… Show more

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“…The effectiveness of IPC in minimizing liver reperfusion injury had already been demonstrated by Santos et al [17] , through the evaluation of its effect directly on liver I/R, as opposed to this study, which analyzed its remote effect. That study showed the effectiveness of the method with three cycles of IPC lasting 30 seconds each, which corroborates the findings of this research, which also found better results with shorter cycles, although there was no statistically significant difference.…”
Section: Discussionmentioning
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“…The effectiveness of IPC in minimizing liver reperfusion injury had already been demonstrated by Santos et al [17] , through the evaluation of its effect directly on liver I/R, as opposed to this study, which analyzed its remote effect. That study showed the effectiveness of the method with three cycles of IPC lasting 30 seconds each, which corroborates the findings of this research, which also found better results with shorter cycles, although there was no statistically significant difference.…”
Section: Discussionmentioning
“…To repair this special area it is mandatory a tissue reperfusion. If this subtle interruption occurs partially or in the whole small intestine, with a high intensity, many times it is not possible to maintain even the basal metabolism and, consequently, there is cell death and tissue necrosis [1][2][3][4] . The intestinal mucosa in the small intestine, it is the first area to be severely affected in cases of ischemia.…”
Section: Introductionmentioning
“…As with IPC, adenosine and nitric oxide play a pivotal role in ischaemic postconditioning. As in the case of IPC, ischaemic post-conditioning can also be achieved by a local postconditioning stimulus (direct IPost) [11,[42][43][44] or by a remote postconditioning stimulus (RIPost) [45] .…”
Section: Ischaemic Postconditioningmentioning
“…In animal models, there is experimental evidence that IPost protects against liver IR injury [42][43][44] . There are currently no randomized controlled trials of ischaemic postconditioning (direct or remote) in either liver resection or liver transplantation.…”
Section: Ischaemic Postconditioningmentioning