CONTEXTO: Vivemos num período de epidemia do trauma. A amputação de indicação traumática incide em uma população jovem e economicamente ativa com repercussão onerosa no âmbito socioeconômico, tornando-se um problema de saúde pública. OBJETIVOS: Conhecer a casuística de amputações traumáticas realizadas na Santa Casa de Campo Grande-MS, entre 2005 e 2008. MÉTODOS: Estudo de prevalência, descritivo, longitudinal e retrospectivo. Amostragem de conveniência, realizada com revisão sistemática de prontuários de pacientes submetidos a amputações de membros inferiores e/ou superiores cuja indicação foi trauma incompatível com reconstrução. Foram excluídos os pacientes que já chegaram amputados no pronto-socorro. Avaliaram-se nível de amputação, faixa etária, sexo e escala do sistema MESS para indicação de amputação traumática. Utilizaram-se o teste quiquadrado e o teste exato de Fisher, considerando um intervalo de confiança de 95%. RESULTADOS: Foram realizadas 108 amputações no período, na faixa etária de dois anos a 78 anos, com média de 36,7 ± 12 anos e mediana de 35 anos. Houve predomínio do sexo masculino em 72% da casuística. O nível de amputação mais executado foi de amputações menores (pododáctilos e quirodáctilos). A causa mais frequente foi lesão decorrente de acidente de trânsito. CONCLUSÕES: As amputações traumáticas atingiram uma população jovem e produtiva, conforme corroborado pela literatura, com predomínio de acidentes de trânsito com lesões ortopédicas e neurológicas associadas.

Ischemic postconditioning was able to minimize reperfusion injury of rats undergone mesenteric ischemia and reperfusion process. There was no difference in the effectiveness of the method comparing two cycles of two minutes with four cycles of 30 seconds by H&E histological evaluation of the ileum after 60-minute reperfusion.

INTRODUCTION Some publications have demonstrated the presence of lung reperfusion injury in mesenteric ischemia and reperfusion (I/R), but under to diverse methods. Postconditioning has been recognized as effective in preventing reperfusion injury in various organs and tissues. However, its effectiveness has not been evaluated in the prevention of lung reperfusion injury after mesenteric ischemia and reperfusion.OBJECTIVE To evaluate the presence of pulmonary reperfusion injury and the protective effect of ischemic postconditioning on lung parenchyma in rats submitted to mesenteric ischemia and reperfusion.METHODS Thirty Wistar rats were distributed into three groups: group A (10 rats), which was held mesenteric ischemia (30 minutes) and reperfusion (60 minutes); group B (10 rats), ischemia and reperfusion, interspersed by postconditioning with two alternating cycles of reperfusion and reocclusion, for two minutes each; and group C (10 rats), ischemia and reperfusion interleaved by postconditioning with four alternating cycles of reperfusion and reocclusion of 30 seconds each. Finally, it was resected the upper lung lobe for histological analysis.RESULTS There were mild lung lesions (grade 1) in all samples. There was no statistical difference between groups 1 and 2 (P>0.05).CONCLUSION The mesenteric ischemia and reperfusion in rats for thirty and sixty minutes, respectively, caused mild reperfusion injury in lung. Postconditioning was not able to minimize the remote reperfusion injury and there was no difference comparing two cycles of two minutes with four cycles of 30 seconds.

IntroductionIschemic postconditioning is a method that shows evidence of efficacy in minimizing reperfusion injury; however, its effectiveness in preventing injuries in distant organs is still unknown, especially in those who have undergone mesenteric ischemia and reperfusion.ObjectiveTo evaluate the effect of ischemic postconditioning in preventing reperfusion injury in the liver of rats submitted to mesenteric ischemia and reperfusion, comparing two different methods of ischemic postconditioning.Methods30 Wistar male rats were used, distributed into three groups: Group A: Ten rats submitted to intestinal ischemia for 30 minutes followed by reperfusion for 60 minutes; Group B: Ten rats subjected to ischemia and reperfusion; after ischemia, two cycles of reperfusion (two minutes each) interleaved with two cycles of ischemia (two minutes each); and Group C: Ten rats subjected to ischemia and reperfusion; after ischemia, four cycles of reperfusion (30 seconds each) interspersed with four cycles of ischemia (30 seconds each). After the experiment, the left lobe of the liver was resected for subsequent histological analysis, using the following classification: grade 1 - centrilobular congestion; grade 2 - centrilobular congestion with some degeneration of hepatocytes in one or two central veins; and grade 3 - multifocal centrilobular congestion and degeneration of portal hepatocytes.ResultsThe mean degree of liver damage found was 1.8 in group A, 1.7 in group B and 1.3 in group C. There was no statistically significant difference between the groups.ConclusionIschemic postconditioning was unable to minimize reperfusion injury in rats undergoing mesenteric ischemia and reperfusion.