Post-traumatic Endophthalmitis Secondary to Keratomycosis Caused by <i>Scedosporium apiospermum</i>

Roy, Rupak; Panigrahi, Pradeep Kumar; Pal, Swakshyar Saumya; Mukherjee, A. S.; Bhargava, Mona

doi:10.3109/09273948.2014.902078

Cited by 8 publications

(4 citation statements)

References 4 publications

(8 reference statements)

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“…Broad-spectrum ocular infections with a variable prognosis caused by SA have been reported in the literature [16][17][18][19][20][21][22][23][24][25][26][27][28][29][30][31][32][33][34][35]; these infections involve the eyelids [19] up to the orbital apex [17]. It can affect both immunocompetent [19, 20, 23-26, 28, 30, 32] and immunocompromised [17,18,21,22,27,29,31,[33][34][35] hosts.…”

Section: Discussionmentioning

confidence: 99%

“…The most severe cases involve a history of conditions that lead to immunodeficiency, allowing a faster and more destructive intraocular growth of SA [17,21,22,27,34,35]. The pharmacological treatment of this infection includes mainly VRCZ, followed by amphotericin B, whereas surgical treatment involves penetrating keratoplasty or more aggressive techniques, such as enucleation/evisceration [16][17][18][19][20][21][22][23][24][25][26][27][28][29][30][31][32][33][34][35]. Table 1 summarizes the studies on patients' demographics, treatment approaches, and the outcomes of ocular infections caused by SA.…”

Section: Discussionmentioning

confidence: 99%

“…Broad-spectrum ocular infections with a variable prognosis caused by SA have been reported in the literature [ 16 - 35 ]; these infections involve the eyelids [ 19 ] up to the orbital apex [ 17 ]. It can affect both immunocompetent [ 19 , 20 , 23 - 26 , 28 , 30 , 32 ] and immunocompromised [ 17 , 18 , 21 , 22 , 27 , 29 , 31 , 33 - 35 ] hosts. Following previous studies on eye infections related to SA, it appears remarkable that most cases require penetrating keratoplasty to restore at least the anatomical structure of the eye [ 16 , 20 , 23 , 26 , 28 , 30 ].…”

Section: Discussionmentioning

confidence: 99%

“…It can affect both immunocompetent [ 19 , 20 , 23 - 26 , 28 , 30 , 32 ] and immunocompromised [ 17 , 18 , 21 , 22 , 27 , 29 , 31 , 33 - 35 ] hosts. Following previous studies on eye infections related to SA, it appears remarkable that most cases require penetrating keratoplasty to restore at least the anatomical structure of the eye [ 16 , 20 , 23 , 26 , 28 , 30 ]. However, a few cases of SA-induced keratitis that were successfully treated with medical treatment alone have been reported [ 24 , 29 , 32 , 33 ].…”

Section: Discussionmentioning

confidence: 99%

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Scedosporium apiospermum contact lens-related keratitis: A rare case report and a literature review

Cassano¹,

Cardascia²,

Tegola³

et al. 2021

Med Hypothesis Discov Innov Ophthalmol

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Background: Scedosporium apiospermum (SA) is commonly present in temperate climates. It can induce cutaneous and subcutaneous tissue infections as well as disseminated infections in immunocompromised or immunocompetent hosts. The eye is rarely involved. Keratomycosis is usually caused by plant-related injuries. Here, we describe a patient with a severe and sight-threatening corneal abscess caused by SA, which was associated with contact lens wear and was successfully treated with a combination of surgical and medical therapies. Case Presentation: An otherwise healthy 22-year-old woman, with history of contact lens wearing, was referred to the Ophthalmic Department of Bari University, Bari, Italy for evaluation of a corneal abscess and hypopyon in her left eye. Intensive topical and systemic antibiotic therapy was initiated after obtaining conjunctival swabs. Within 2 days, her ophthalmic condition had worsened, and her best-corrected visual acuity (BCVA) dropped to counting fingers. She underwent penetrating keratoplasty, after which her ophthalmic condition improved. Microbiological culture, obtained from the explanted cornea, revealed SA infection. This was addressed with specific topical and systemic therapy using voriconazole. Two weeks later, the condition of her left eye was stable, with mild corneal edema and no sign of acute graft rejection. Her BCVA improved to 20/25, and all medications were discontinued, except for the steroid eye drop. The patient was scheduled for a 1-month follow-up. Conclusions: Prompt identification of the etiological agent is mandatory to perform appropriate therapy in cases of keratomycosis. Surgery to remove the infected cornea is helpful in patients with deteriorating condition, in whom the initial medical therapy has failed. Topical and systemic antimycotic therapy, based on microbiological culture, is recommended as an adjunctive therapy for the surgical management of severe corneal mycotic abscesses. How to cite this article: Cassano F, Cardascia N, Tegola MGL, Boscia F, Alessio G. Scedosporium apiospermum contact lens-related keratitis: A rare case report and a literature review. Med Hypothesis Discov Innov Ophthalmol. 2021 Summer, 10(2): 80-85 https://doi.org/10.51329/mehdiophthal1425

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Scedosporium apiospermum contact lens-related keratitis: A rare case report and a literature review

Cassano¹,

Cardascia²,

Tegola³

et al. 2021

Med Hypothesis Discov Innov Ophthalmol

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Eye fungal infections: a mini review

Reginatto,

Agostinetto,

Fuentefria

et al. 2023

Arch Microbiol

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Ocular fungal infections annually affect more than one million individuals worldwide. The management of these infections is problematic, mainly due to the limited availability of effective antifungal agents. Thus, ocular infections are increasingly recognized as important causes of morbidity and blindness, especially keratitis and endophthalmitis. Thus, this review aims to demonstrate the importance of fungal eye infections through the description of the main related aspects, with emphasis on the treatment of these infections. For this purpose, a search for scientific articles was conducted in databases, such as Medline, published from 2000 onwards, addressing important aspects involving fungal eye infections. In addition, this work highlighted the limited therapeutic arsenal available and the severity associated with these infections. Thus, highlighting the importance of constantly updating knowledge about these pathologies, as it contributes to agility in choosing the available and most appropriate therapeutic alternatives, aiming at positive and minimally harmful results for that particular patient.

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Pseudallescheria/Scedosporium complex species: From saprobic to pathogenic fungus

Luplertlop

2018

Journal de Mycologie Médicale

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Post-traumatic Endophthalmitis Secondary to Keratomycosis Caused by Scedosporium apiospermum

Cited by 8 publications

References 4 publications

Scedosporium apiospermum contact lens-related keratitis: A rare case report and a literature review

Scedosporium apiospermum contact lens-related keratitis: A rare case report and a literature review

Eye fungal infections: a mini review

Pseudallescheria/Scedosporium complex species: From saprobic to pathogenic fungus

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