Eye fungal infections: a mini review

Reginatto, Paula; Agostinetto, Giovanna de Jesus; Fuentefria, Rubia do Nascimento; Marinho, Diane Ruschel; Pizzol, Melissa Dal; Fuentefria, Alexandre Meneghello

doi:10.1007/s00203-023-03536-6

Cited by 20 publications

(9 citation statements)

References 78 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In this context, the most relevant pathogenic fungi of the eye are Fusarium , Aspergillus spp., and Candida spp., and the most important fungal infections are keratitis and endophthalmitis because of their high risk of blindness [ 10 ].…”

Section: Fungal Ocular Infectionmentioning

confidence: 99%

Candida Biofilm Eye Infection: Main Aspects and Advance in Novel Agents as Potential Source of Treatment

et al. 2023

View full text Add to dashboard Cite

Fungi represent a very important cause of microbial eye infections, especially in tropical and developing countries, as they could cause sight-threating disease, such as keratitis and ocular candidiasis, resulting in irreversible vision loss. Candida species are among the most frequent microorganisms associated with fungal infection. Although Candida albicans is still the most frequently detected organism among Candida subspecies, an important increase in non-albicans species has been reported. Mycotic infections often represent an important diagnostic-clinical problem due to the difficulties in performing the diagnosis and a therapeutic problem due to the limited availability of commercial drugs and the difficult penetration of antifungals into ocular tissues. The ability to form biofilms is another feature that makes Candida a dangerous pathogen. In this review, a summary of the state-of-the-art panorama about candida ocular pathology, diagnosis, and treatment has been conducted. Moreover, we also focused on new prospective natural compounds, including nanoparticles, micelles, and nanocarriers, as promising drug delivery systems to better cure ocular fungal and biofilm-related infections. The effect of the drug combination has also been examined from the perspective of increasing efficacy and improving the course of infections caused by Candida which are difficult to fight.

show abstract

Section: Fungal Ocular Infectionmentioning

confidence: 99%

Candida Biofilm Eye Infection: Main Aspects and Advance in Novel Agents as Potential Source of Treatment

et al. 2023

View full text Add to dashboard Cite

show abstract

“…These diseases are mainly caused by bacteria, with the Gram-positive Staphylococcus epidermidis and Staphylococcus aureus as the predominantly involved species [4][5][6]. Although at a lower rate than bacteria, fungi, viruses, and parasites can also be responsible for ocular infections [7,8].…”

Section: Introductionmentioning

confidence: 99%

Anti-Staphylococcal Biofilm Effects of a Liposome-Based Formulation Containing Citrus Polyphenols

Mazzantini,

Massimino,

Calvigioni

et al. 2024

Antibiotics

View full text Add to dashboard Cite

Biofilms are surface-associated microbial communities embedded in a matrix that is almost impenetrable to antibiotics, thus constituting a critical health threat. Biofilm formation on the cornea or ocular devices can lead to serious and difficult-to-treat infections. Nowadays, natural molecules with antimicrobial activity and liposome-based delivery systems are proposed as anti-biofilm candidates. In this study, the anti-biofilm activity of a formulation containing citrus polyphenols encapsulated in liposomes was evaluated against Staphylococcus aureus and Staphylococcus epidermidis, the most common agents in ocular infections. The formulation activity against planktonic staphylococci was tested by broth microdilution and sub-inhibitory concentrations were used to evaluate the effect on biofilm formation using the crystal violet (CV) assay. The eradicating effect of the preparation on mature biofilms was investigated by the CV assay, plate count, and confocal laser scanning microscopy. The product was bactericidal against staphylococci at a dilution of 1:2 or 1:4 and able to reduce biofilm formation even if diluted at 1:64. The formulation also had the ability to reduce the biomass of mature biofilms without affecting the number of cells, suggesting activity on the extracellular matrix. Overall, our results support the application of the used liposome-encapsulated polyphenols as an anti-biofilm strategy to counter biofilm-associated ocular infections.

show abstract

“…The prognosis of fungal keratitis is decided by the balance between the invading fungus and the host's defense. The immuno-inflammation and oxidative stress of cornea is a double-edged sword: while restricted reactions protect against pathogens, excessive and persistent reactions also bring damage to the ocular tissue [ 10 ]. Unfortunately, current therapeutic drugs are incapable of lessening inflammatory reactions; in addition, they are constrained by poor corneal permeability and strong side effects [ 11 ].…”

Section: Introductionmentioning

confidence: 99%

Ebselen improves fungal keratitis through exerting anti-inflammation, anti-oxidative stress, and antifungal effects

Yu,

Wang,

Zhang

et al. 2024

Redox Biology

View full text Add to dashboard Cite

Eye fungal infections: a mini review

Cited by 20 publications

References 78 publications

Candida Biofilm Eye Infection: Main Aspects and Advance in Novel Agents as Potential Source of Treatment

Candida Biofilm Eye Infection: Main Aspects and Advance in Novel Agents as Potential Source of Treatment

Anti-Staphylococcal Biofilm Effects of a Liposome-Based Formulation Containing Citrus Polyphenols

Ebselen improves fungal keratitis through exerting anti-inflammation, anti-oxidative stress, and antifungal effects

Contact Info

Product

Resources

About