“…Probiotics, as well as fecal microbiota transplantation, prebiotics, and nutritional interventions, display functions in reversing gut microbiota dysbiosis, restoring gut permeability, and rescuing bone loss. Probiotic administration has been considered to be a potential novel target for regulating bone homeostasis to prevent bone diseases such as OP in humans, and in various animal models with induced bone loss [ 167 , 174 , 175 , 176 ]. However, studies have shown a range of variations in the incurred benefits of probiotics; and their efficiency is species-specific due to multiple factors, including the strains of the probiotics and the host’s physical and physiological state [ 53 , 54 , 55 ].…”