Possible mechanism underlying the effect of Heshouwuyin, a tonifying kidney herb, on sperm quality in aging rats

Niu, Sijie; Duan, Fei; Song, Qingliang; Qin, Mingyue; Wang, Zhenshan; Liu, Jingze

doi:10.1186/1472-6882-14-250

Cited by 10 publications

(11 citation statements)

References 19 publications

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“…FT binds to androgen receptors, which then influence the expression of certain genes and exert an androgenic effect. Reduced T secretion and germ cell apoptosis can cause abnormal sperm (Barsiah et al., 2019), and weakened gonadal function that eventually leads to sexual dysfunction (Niu et al., 2014). Insufficient serum T levels can cause muscle mass loss, weight gain, erectile dysfunction, increased fatigue, and low libido.…”

Section: Discussionmentioning

confidence: 99%

The beneficial effect of oyster peptides and oyster powder on cyclophosphamide‐induced reproductive impairment in male rats: A comparative study

Zhou

Wei

et al. 2020

J. Food Biochem.

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In addition to being nutritional elements, proteins in food can also regulate the body's physiological functions, which is achieved via specific peptide sequences in the proteins (Chakrabarti, Guha, & Majumder, 2018). Therefore, although many bioactive peptides are stored in dietary proteins, the peptides remain inactive in the protein sequence and only have specific physiological functions after being released (Kitts & Weiler, 2003). Proteases from various sources can release biologically active peptides (Korhonen & Pihlanto, 2006), which are absorbed by the body via a different absorption route than the protein (Silk, Grimble, & Rees, 1985). Bioactive peptides can be absorbed directly from the intestine into the bloodstream, where they are highly active, exhibiting physiological effects in small amounts. The bioactive peptide activity is controlled by the composition and sequence of amino acids (Chakrabarti et al., 2018), and many peptides are known to reveal multifunctional properties

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Section: Discussionmentioning

confidence: 99%

The beneficial effect of oyster peptides and oyster powder on cyclophosphamide‐induced reproductive impairment in male rats: A comparative study

Zhou

Wei

et al. 2020

J. Food Biochem.

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“…Haraldson (Polygonaceae) (dried root) [heshouwu] as the main medicine. We previously showed that Heshouwuyin has many curative effects (Niu et al 2012(Niu et al , 2014Chen et al 2016). It can reduce the concentration of gonadotropin-releasing hormone (GnRH), luteinizing hormone (LH) and follicle-stimulating hormone (FSH) in aging rats and increase the testosterone concentration.…”

Section: Introductionmentioning

confidence: 99%

Effects of Heshouwuyin on gene expression of the insulin/IGF signalling pathway in rat testis and spermatogenic cells

Wang

Shan

Duan

et al. 2020

Pharmaceutical Biology

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Context: The Chinese herbal formula Heshouwu decoction (Heshouwuyin) has protective effects on testicular function in aging male rats, but the mechanism is unknown. Objective: This study investigated whether Heshouwuyin affects the testicular function of aging rats by regulating the insulin/IGF signalling pathway. Materials and methods: Sixteen-month-old male Wistar rats in the Heshouwuyin group and the naturalaging group were orally administered Heshouwuyin granules (0.056 g/kg) or equivalent normal saline for 60 d. The testicular tissue of 12-month-old male Wistar rats was removed as a young control group (n ¼ 10). The testicular tissue and spermatogenic cells were studied. Results: The immunofluorescence results revealed that the insulin receptor (INSR)-(0.056 ± 0.00548), insulin receptor substrate 1(IRS1)-(0.251 ± 0.031), IRS2 (0.230 ± 0.019)-and insulin-like growth factor 1 (IGF1)positive cell rate (0.33 ± 0.04) in the aging group was higher than that in the young control group (0.116 ± 0.011, 0.401 ± 0.0256, 0.427 ± 0.031, 0.56 ± 0.031; p < 0.01), and the IGF-binding protein 3 (IGFBP3)positive cell rate (0.42 ± 0.024) was lower than that (0.06 ± 0.027) in the young group (p < 0.01). The intervention of Heshouwuyin reversed the above phenomena. The qPCR and immunoblot results were consistent with those of the immunofluorescence. The same results were obtained in spermatogenic cells. Conclusions: Our research shows that Heshouwuyin can regulate the insulin/IGF signalling pathway to improve testicular function, and provides an experimental basis for further clinical use.

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“…They are widely distributed worldwide and have been used as herbal drugs and healthcare products for centuries [2]. These extracts have a wide range of pharmacological activities including anti-aging [3, 4], anti-oxidant [5, 6], anti-tumor [7, 8], neuroprotective [9, 10], hair blacking [11], liver cirrhosis treatment [12], and lipid regulation effects [13–15]. Their functions are due to their flavonoid, phenolic acid, and 2,3,5,4′-tetrahydroxystilbene-2- O -β- d -glucoside (THSG) compositions [16].…”

Section: Introductionmentioning

confidence: 99%

Metabolomics profiling of Polygoni Multiflori Radix and Polygoni Multiflori Radix Preparata extracts using UPLC-Q/TOF-MS

2019

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BackgroundThe side effects caused by Polygoni Multiflori Radix (PMR) and Polygoni Multiflori Radix Praeparata (PMRP) have often appeared globally. There is no research on the changes of endogenous metabolites among PMR- and PMRP-treated rats. The aim of this study was to evaluate the varying metabolomic effects between PMR- and PMRP-treated rats. We tried to discover relevant differences in biomarkers and endogenous metabolic pathways.MethodsHematoxylin and eosin staining and immunohistochemistry staining were performed to find pathological changes. Biochemical indicators were also measured, one-way analysis of variance with Dunnett’s multiple comparison test was used for biochemical indicators comparison among various groups. Metabolomics analysis based on ultra-high performance liquid chromatography-quadrupole time of flight mass spectrometry (UPLC-Q/TOF-MS) was performed to find the changes in metabolic biomarkers. Multivariate statistical approaches such as principal component analysis (PCA) and orthogonal partial least square-discriminant analysis (OPLS-DA) were applied to reveal group clustering trend, evaluate and maximize the discrimination between the two groups. MetaboAnalyst 4.0 was performed to find and confirm the pathways.ResultsPMR extracts exhibited slight hepatotoxic effects on the liver by increasing aspartate and alanine aminotransferase levels. Twenty-nine metabolites were identified as biomarkers, belonging to five pathways, including alpha-linolenic acid metabolism, taurine and hypotaurine metabolism, glycerophospholipid metabolism, arginine and proline metabolism, and primary bile acid biosynthesis.ConclusionThis study provided a comprehensive description of metabolomic changes between PMR- and PMRP-treated rats. The underlying mechanisms require further research.

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Possible mechanism underlying the effect of Heshouwuyin, a tonifying kidney herb, on sperm quality in aging rats

Cited by 10 publications

References 19 publications

The beneficial effect of oyster peptides and oyster powder on cyclophosphamide‐induced reproductive impairment in male rats: A comparative study

The beneficial effect of oyster peptides and oyster powder on cyclophosphamide‐induced reproductive impairment in male rats: A comparative study

Effects of Heshouwuyin on gene expression of the insulin/IGF signalling pathway in rat testis and spermatogenic cells

Metabolomics profiling of Polygoni Multiflori Radix and Polygoni Multiflori Radix Preparata extracts using UPLC-Q/TOF-MS

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