Possibilities of using of nanocrystalline CeO2 for bone tissue defects

Morphometry Results of Formed Osteodefects When Using Nanocrystalline CeO2 in the Early Stages of Regeneration

“…e authors plan further in vivo studies to study the biochemical processes observed in the destruction of dentin. It is known that CeO 2 nanoparticles participate in the redox process and can act as oxidoreductases-enzymes that regulate this process in biological systems [3,4]. We suggest that this process may affect the plastic function of odontoblasts and stimulate dentinogenesis.…”

“…Solution strived for is the creation of optimal conditions for reparative osteogenesis and the prevention of pathological bone tissue regeneration. Optimization of reparative bone tissue regeneration processes is of key importance, and the search for new materials that contribute to the creation of optimal conditions for the formation of bone tissue remains relevant [1][2][3][4].…”

“…Recent researches and studies have found unique biochemical properties of nanocrystalline cerium dioxide. In vitro experimental studies have shown that cerium dioxide, CeO 2 , provides improved cell proliferation and provides antibacterial and antiviral effect [3][4][5][6][7]8].…”

“…e catalase-like activity of nanocrystalline cerium dioxide depends on the content of cerium (III) ions on the surface of CeO 2 particles and on the pH of the medium (with an increase in pH >7, the catalase-like activity increases and decreases with decreasing pH). In acidic media at pH <6, nanocrystalline CeO 2 exhibits the properties of oxidoreductases [3,4]. e ability of nanocrystalline CeO 2 to perform the functions of enzymes represents an undeniable perspective when arresting all sorts of pathological processes associated with oxidative stress.…”