Morphometry Results of Formed Osteodefects When Using Nanocrystalline CeO<sub>2</sub> in the Early Stages of Regeneration

Лукин, А. В.; Lukina, G I; Волков, А. В.; Baranchikov, А. Е.; Ivanov, V. K.; Prokopov, Alexey

doi:10.1155/2019/9416381

Cited by 4 publications

(4 citation statements)

References 3 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This is why the medicine is called "smart" and makes CeO 2 a promising agent for use in nanomedicine [30][31][32][33][34][35]. In particular, it allows one to stabilize the wound environment to neutralize reactive oxygen species or any other free radicals, providing antioxidant, antibacterial, and anti-inflammatory effects [1,26,[35][36][37]. The effect of electron transfer can be repeated many times as the wound discharge penetrates through the polysaccharide hydrogel structure directly to the CeO 2 nanoparticles, or if the wound flora changes.…”

Section: Introductionmentioning

confidence: 99%

Efficacy of A Novel Smart Polymeric Nanodrug in the Treatment of Experimental Wounds in Rats

et al. 2020

View full text Add to dashboard Cite

High-quality and aesthetic wound healing, as well as effective medical support of this process, continue to be relevant. This study aims to evaluate the medical efficacy of a novel smart polymeric nanodrug (SPN) on the rate and mechanism of wound healing in experimental animals. The study was carried out in male Wistar rats (aged 8–9 months). In these animals, identical square wounds down to the fascia were made in non-sterile conditions on the back on both sides of the vertebra. SPN was used for the treatment of one wound, and the other wound was left without treatment (control group). Biocompatible citrate-stabilized cerium oxide nanoparticles integrated into a polysaccharide hydrogel matrix containing natural and synthetic polysaccharide polymers (pectin, alginate, chitosan, agar-agar, water-soluble cellulose derivatives) were used as the therapeutic agent. Changes in the wound sizes (area, volume) over time and wound temperature were assessed on Days 0, 1, 3, 5, 7, and 14. Histological examination of the wounds was performed on Days 3, 7, and 14. The study showed that the use of SPN accelerated wound healing in comparison with control wounds by inhibiting the inflammatory response, which was measured by a decreased number of white blood cells in SPN-treated wounds. It also accelerated the development of fibroblasts, with an early onset of new collagen synthesis, which eventually led to the formation of more tender postoperative scars. Thus, the study demonstrated that the use of SPN for the treatment of wounds was effective and promising.

show abstract

Section: Introductionmentioning

confidence: 99%

Efficacy of A Novel Smart Polymeric Nanodrug in the Treatment of Experimental Wounds in Rats

et al. 2020

View full text Add to dashboard Cite

show abstract

“…Suspension of calcium hydroxide was used as the control. This assay showed that nanocrystalline CeO 2 could improve osteogenesis and decrease inflammatory response [169].…”

Section: Cerium Dioxide Nanoparticlesmentioning

confidence: 92%

Nanomaterials in Bone Regeneration

et al. 2022

View full text Add to dashboard Cite

Nanomaterials are promising in the development of innovative therapeutic options that include tissue and organ replacement, as well as bone repair and regeneration. The expansion of new nanoscaled biomaterials is based on progress in the field of nanotechnologies, material sciences, and biomedicine. In recent decades, nanomaterial systems have bridged the line between the synthetic and natural worlds, leading to the emergence of a new science called nanomaterial design for biological applications. Nanomaterials replicating bone properties and providing unique functions help in bone tissue engineering. This review article is focused on nanomaterials utilized in or being explored for the purpose of bone repair and regeneration. After a brief overview of bone biology, including a description of bone cells, matrix, and development, nanostructured materials and different types of nanoparticles are discussed in detail.

show abstract

“… 76 Nanocrystalline CeO 2 promotes dentinogenesis in the damaged teeth root. 209 All aforementioned osteogenic properties of cerium‐doped innovative nanomaterials indicate the potential applications of cerium in bone tissue engineering and implantology.…”

Section: Application Of Re Smart Nano‐biomaterials In Bone Tissue Engineeringmentioning

confidence: 99%

Rare earth smart nanomaterials for bone tissue engineering and implantology: Advances, challenges, and prospects

Duraipandy

Wang

et al. 2021

Bioengineering & Transla Med

View full text Add to dashboard Cite

Bone grafts or prosthetic implant designing for clinical application is challenging due to the complexity of integrated physiological processes. The revolutionary advances of nanotechnology in the biomaterial field expedite and endorse the current unresolved complexity in functional bone graft and implant design. Rare earth (RE) materials are emerging biomaterials in tissue engineering due to their unique biocompatibility, fluorescence upconversion, antimicrobial, antioxidants, and anti‐inflammatory properties. Researchers have developed various RE smart nano‐biomaterials for bone tissue engineering and implantology applications in the past two decades. Furthermore, researchers have explored the molecular mechanisms of RE material‐mediated tissue regeneration. Recent advances in biomedical applications of micro or nano‐scale RE materials have provided a foundation for developing novel, cost‐effective bone tissue engineering strategies. This review attempted to provide an overview of RE nanomaterials' technological innovations in bone tissue engineering and implantology and summarized the osteogenic, angiogenic, immunomodulatory, antioxidant, in vivo bone tissue imaging, and antimicrobial properties of various RE nanomaterials, as well as the molecular mechanisms involved in these biological events. Further, we extend to discuss the challenges and prospects of RE smart nano‐biomaterials in the field of bone tissue engineering and implantology.

show abstract

Morphometry Results of Formed Osteodefects When Using Nanocrystalline CeO₂ in the Early Stages of Regeneration

Cited by 4 publications

References 3 publications

Efficacy of A Novel Smart Polymeric Nanodrug in the Treatment of Experimental Wounds in Rats

Efficacy of A Novel Smart Polymeric Nanodrug in the Treatment of Experimental Wounds in Rats

Nanomaterials in Bone Regeneration

Rare earth smart nanomaterials for bone tissue engineering and implantology: Advances, challenges, and prospects

Contact Info

Product

Resources

About

Morphometry Results of Formed Osteodefects When Using Nanocrystalline CeO2 in the Early Stages of Regeneration

Cited by 4 publications

References 3 publications

Efficacy of A Novel Smart Polymeric Nanodrug in the Treatment of Experimental Wounds in Rats

Efficacy of A Novel Smart Polymeric Nanodrug in the Treatment of Experimental Wounds in Rats

Nanomaterials in Bone Regeneration

Rare earth smart nanomaterials for bone tissue engineering and implantology: Advances, challenges, and prospects

Contact Info

Product

Resources

About

Morphometry Results of Formed Osteodefects When Using Nanocrystalline CeO₂ in the Early Stages of Regeneration