Positive surgical margins after radical prostatectomy: What should we care about?

Pettenati, C.; Radulescu, C.; Hervé, Jean-Marie; Molinié, Vincent; Lebrét, Thierry

doi:10.1007/s00345-015-1580-x

Cited by 19 publications

(12 citation statements)

References 31 publications

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“…PSM is a frequent situation encountered after radical prostatectomy (RP) for localised PCa with an occurrence ranging from 6 to 41% [ 9 , 26 , 27 ]. The incidence of PSM depends on various factors, including tumour biology, patient characteristics, pathological assessment method, and surgical technique [ 28 ].…”

Section: Discussionmentioning

confidence: 99%

Positive surgical margin is associated with biochemical recurrence risk following radical prostatectomy: a meta-analysis from high-quality retrospective cohort studies

Zhang

Zha

et al. 2018

World J Surg Onc

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Background and purposeAlthough numerous studies have shown that positive surgical margin (PSM) is linked to biochemical recurrence (BCR) in prostate cancer (PCa), the research results have been inconsistent. This study aimed to explore the association between PSM and BCR in patients with PCa following radical prostatectomy (RP).Materials and methodsIn accordance with the guidelines of the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA), PubMed, EMBASE and Wan Fang databases were searched for eligible studies from inception to November 2017. The Newcastle–Ottawa Scale was used to assess the risk of bias of the included studies. Meta-analysis was performed by using Stata 12.0. Combined hazard ratios (HRs) and their corresponding 95% confidence intervals (CIs) were calculated using random-effects or fixed-effects models.ResultsUltimately, 41 retrospective cohort studies of high quality that met the eligibility criteria, comprising 37,928 patients (94–3294 per study), were included in this meta-analysis. The results showed that PSM was associated with higher BCR risk in both univariate analysis (pooled HR = 1.56; 95% CI 1.46, 1.66; p < 0.001) and multivariate analysis (pooled HR = 1.35; 95% CI 1.27, 1.43; p < 0.001). Moreover, no potential publication bias was observed among the included studies in univariate analysis (p-Begg = 0.971) and multivariate analysis (p-Begg = 0.401).ConclusionsOur meta-analysis demonstrated that PSM is associated with a higher risk of BCR in PCa following RP and could serve as an independent prognostic factor in patients with PCa.Electronic supplementary materialThe online version of this article (10.1186/s12957-018-1433-3) contains supplementary material, which is available to authorized users.

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Section: Discussionmentioning

confidence: 99%

Positive surgical margin is associated with biochemical recurrence risk following radical prostatectomy: a meta-analysis from high-quality retrospective cohort studies

Zhang

Zha

et al. 2018

World J Surg Onc

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“…Preoperative and postoperative assessment of continence and EF was done by means of self-administered questionnaires filled by the patient. In order to provide clear data regarding the effect of ePLND on continence and EF recovery and to avoid any confounding factors, the following were excluded from the analyses: neoadjuvant/adjuvant therapy, positive lymph node disease and positive surgical margins [12]. There are hints in the literature that phosphodiesterase type 5 inhibitors (PDE-5i) may adversely impact biochemical recurrence (BCR) after RP [13].…”

Section: Study Population and Designmentioning

confidence: 99%

Extended versus limited pelvic lymph node dissection during bilateral nerve-sparing radical prostatectomy and its effect on continence and erectile function recovery: long-term results and trifecta rates of a comparative analysis

Hatzichristodoulou

Wagenpfeil

et al. 2015

World J Urol

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“…SM positivity is defined only if cancer cells are detected on the surface of the RP specimen during microscopic evaluation [8]. SM positivity occurs with a range from 6 to 41% after RP for localized PCa [9-11]. In the current study, SM positivity was seen in 33.8% of our population.…”

Section: Discussionmentioning

confidence: 68%

Factors Affecting Surgical Margin Positivity after Radical Prostatectomy in the Turkish Population: A Multicenter Study of the Urooncology Association

et al. 2020

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Background: The prediction of positive surgical margins (SM) after radical prostatectomy (RP) is important for planning the surgical modality and adjuvant therapy in patients with prostate cancer (PCa). Objectives: To investigate factors affecting SM positivity in patients diagnosed with PCa who underwent RP using the PCa database of the Urooncology Association (Turkey). Methods: Patients who underwent RP due to clinically T1c-T3 PCa and who had detailed SM data for the RP specimen were included in the study. Pathological data of 12 core transrectal ultrasound prostate biopsies and RP were evaluated. Patients were divided into 2 groups (SM positive and SM negative) according to SM status after RP. Data were compared between the groups. Factors affecting SM positivity, the number of positive SM sites, and the loca

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Positive surgical margins after radical prostatectomy: What should we care about?

Cited by 19 publications

References 31 publications

Positive surgical margin is associated with biochemical recurrence risk following radical prostatectomy: a meta-analysis from high-quality retrospective cohort studies

Positive surgical margin is associated with biochemical recurrence risk following radical prostatectomy: a meta-analysis from high-quality retrospective cohort studies

Extended versus limited pelvic lymph node dissection during bilateral nerve-sparing radical prostatectomy and its effect on continence and erectile function recovery: long-term results and trifecta rates of a comparative analysis

Factors Affecting Surgical Margin Positivity after Radical Prostatectomy in the Turkish Population: A Multicenter Study of the Urooncology Association

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