Factors Affecting Surgical Margin Positivity after Radical Prostatectomy in the Turkish Population: A Multicenter Study of the Urooncology Association

Abstract

Background: The prediction of positive surgical margins (SM) after radical prostatectomy (RP) is important for planning the surgical modality and adjuvant therapy in patients with prostate cancer (PCa). Objectives: To investigate factors affecting SM positivity in patients diagnosed with PCa who underwent RP using the PCa database of the Urooncology Association (Turkey). Methods: Patients who underwent RP due to clinically T1c-T3 PCa and who had detailed SM data for the RP specimen were included in the study. Pathological data of 12 core transrectal ultrasound prostate biopsies and RP were evaluated. Patients were divided into 2 groups (SM positive and SM negative) according to SM status after RP. Data were compared between the groups. Factors affecting SM positivity, the number of positive SM sites, and the loca

Predictive Factors for Positive Surgical Margins in Patients With Prostate Cancer After Radical Prostatectomy: A Systematic Review and Meta-Analysis

“…Then, 295 full-text articles were further examined and 268 articles were excluded because 27 articles included the same cohort of patients and 241 articles lacked enough data for further research. Finally, 27 articles ( 8 , 15 – 40 ) published between 2009 and 2020 were included in this meta-analysis.…”

The Effect of Adverse Patient Characteristics on Perioperative Outcomes in Open and Robot-Assisted Radical Prostatectomy

“…This could be explained by limited sample size and that the obese subgroup had the fewest number of patients. However, other studies suggest that there might be a detrimental effect of high BMI on PSM (5,6,24).…”

“…It is commonly accepted that adverse preoperative tumor characteristics such as clinical stage (cT), Gleason score and PSA are associated with adverse perioperative results, such as increased blood loss, increased operation (OR) time, positive surgical margins (PSM) or lower probability of neurovascular bundle preservation (NVBP) ( 3 , 4 ). However, non-tumor-related adverse patient characteristics such as obesity or high prostate volume might also deteriorate perioperative results ( 5 , 6 ). This seems even more relevant as adverse perioperative results represent strong predictors of long term oncological and functional outcomes after RP ( 7 – 10 ).…”

Perineural invasion detected in prostate biopsy is a predictor of positive surgical margin of radical prostatectomy specimen: A meta‐analysis

“…They believe that biopsy PNI could predict PSM independent of PSA and Gleason score. Çelik et al (Çelik et al, 2020) biopsy PNI was found to be independent predictor for PSM and the number of PSM locations. But, Cannon et al (Cannon et al, 2005) found that biopsy PNI was associated with extraprostatic extension but did not predict the prognosis of radical prostatectomy with preserved NVB and positive surgical margins.…”

“…Since our study revealed that biopsy PNI was a predictor of PSM of prostate cancer, It also correlated with the number of positive incisional margin locations. In addition, positive posterior lateral surgical margins were associated with biopsy PNI and the surgical approach to nerve preservation (Çelik et al, 2020). The nerve‐sparing RP approach is performed to protect erectile function after surgery.…”