Positive Correlation of Fecal Calprotectin With Serum Antioxidant Enzymes in Patients With Inflammatory Bowel Disease: Accidental Numerical Correlation or a New Finding?

Vaghari‐Tabari, Mostafa; Moein, Soheila; Qujeq, Durdi; Kashifard, Mehrdad; Hajian‐Tilaki, Karimollah

doi:10.1016/j.amjms.2017.12.009

Cited by 25 publications

(21 citation statements)

References 19 publications

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“…Besides, GPx activity has a significant negative correlation with DA score and positive correlation with GR activity. The current results are not in agreement with those reporting that the serum concentration of GPX showed a positive correlation with disease histopathologic activity index in ulcerative colitis patients (54). Nevertheless, the present study showed a significant decrease in GPx and GR activity in all patients compared to controls yet in females, the decrease was not significant.…”

Section: Discussioncontrasting

confidence: 99%

Inappropriate Total Oxidant/Antioxidant Status, Nitric Oxide Oxidation End Products and Trace Element Levels in Patients with Inflammatory Bowel Disease

Mohammadi¹,

Qujeq²,

Taheri³

et al. 2018

Ann Colorectal Res

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Background: This study aimed at evaluating oxidant and antioxidant markers (including nitrite, nitrate, total antioxidant capacity (TAC), malondialdehyde (MDA), iron, selenium, glutathione peroxidase (GPx), and glutathione reductase (GR) in patients with inflammatory bowel disease (IBD) and compare them with healthy controls. Methods: Serum samples were obtained from 35 patients (19 ulcerative colitis (UC) and 16 Crohn's disease (CD) in the active phase of the disease) and 30 healthy controls. Serum levels of nitrite and nitrate, TAC, MDA, iron, selenium, glutathione peroxidase, and glutathione reductase were measured. The results were compared between the two groups using independent t-student test. The Pearson's correlation coefficient (for continuous data) was performed using the SPSS software. Results: Serum levels of nitrite, nitrate, and MDA were significantly higher (P = 0.001) in patients with IBD, while the levels of TAC, trace elements, glutathione peroxidase (GPx), and Glutathione Reductase (GR) levels were lower (P < 0.05) in patients with IBD. However, when females were considered separately, Gpx and GR activities were not significantly different in those with and without IBD. The present results showed that nitrite, MDA, GPx, GR, and Se: MDA ratio had the strongest correlation with disease activity score. Conclusions: There is an imbalance between oxidant and antioxidant properties in patients with IBD, which highlights the role of oxidative stress in the pathogenesis of this disease.

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Section: Discussioncontrasting

confidence: 99%

Inappropriate Total Oxidant/Antioxidant Status, Nitric Oxide Oxidation End Products and Trace Element Levels in Patients with Inflammatory Bowel Disease

Mohammadi¹,

Qujeq²,

Taheri³

et al. 2018

Ann Colorectal Res

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“…From among secondary lipid peroxidation markers (if not otherwise stated, reviewed in Supplementary Table S6), MDA has indeed been studied most often. Four reports of reduction [26,39,71,92] are contradicted by 17, in which the accumulation of MDA has been observed, either in tissue [44], erythrocytes [34], saliva [16,17,37], or serum/plasma [21,27,[36][37][38]40,41,48,72,86,93,94].…”

Section: Diagnostic Markers In Ibd (Markers Not Specific For Either Umentioning

confidence: 97%

“…The activities of intracellular CAT and GPx determined in leukocytes obtained from an adult and a pediatric population, have been decreased and unaltered, respectively [35][36][37]. The activity of extracellular GPx isoform has been observed to drop [38] or increase [39,40] in IBD. In studies evaluating CD patients, GPx has been increased [39], increased only in active disease [41], or remained unaltered [42,43].…”

Section: Diagnostic Markers In Ibd (Markers Not Specific For Either Umentioning

confidence: 99%

“…CAT activity has been also measured in tissue homogenates, but no significant differences between CD and UC patients and healthy controls have been observed [44], similarly to GPx determined in saliva [38]. Interestingly, some authors have measured plasma or serum activity of catalase although, unlike for SOD and GPx, the extracellular isoforms of the enzyme have yet to be reported [26,40].…”

Section: Diagnostic Markers In Ibd (Markers Not Specific For Either Umentioning

confidence: 99%

“…From among low-molecular antioxidants (if not otherwise stated, reviewed in Supplementary Table S4), the most commonly assessed was, so called, total antioxidant status or total antioxidant capacity (respectively, TAS or TAC), a cumulative measure reflecting a sample's power to resist the prooxidant action, to which all present antioxidants are believed to contribute. If measured in serum or plasma, it seems to have been almost unanimously decreased in IBD, both CD and UC and regardless very diverse methodology, but exclusively in adult patients [20,23,37,40,[69][70][71] (Table 1 and Supplementary Table S4). Koutroubakis et al [70] evaluated TAS as well as a parameter referred to as corrected TAS, in which the contribution of albumin, uric acid, and bilirubin has been subtracted.…”

Section: Diagnostic Markers In Ibd (Markers Not Specific For Either Umentioning

confidence: 99%

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Oxidative Stress Markers in Inflammatory Bowel Diseases: Systematic Review

et al. 2020

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Precise diagnostic biomarker in inflammatory bowel diseases (IBD) is still missing. We conducted a comprehensive overview of oxidative stress markers (OSMs) as potential diagnostic, differential, progression, and prognostic markers in IBD. A Pubmed, Web of Knowledge, and Scopus search of original articles on OSMs in IBD, published between January 2000 and April 2020, was conducted. Out of 874 articles, 79 eligible studies were identified and used to prepare the interpretative synthesis. Antioxidants followed by lipid peroxidation markers were the most popular and markers of oxidative DNA damage the least popular. There was a disparity in the number of retrieved papers evaluating biomarkers in the adult and pediatric population (n = 6). Of the reviewed OSMs, a promising performance has been reported for serum total antioxidant status as a mucosal healing marker, mucosal 8-OHdG as a progression marker, and for multi-analyte panels of lipid peroxidation products assessed non-invasively in breath as diagnostic and differential markers in the pediatric population. Bilirubin, in turn, was the only validated marker. There is a desperate need for non-invasive biomarkers in IBD which, however, will not be met in the near future by oxidative stress markers as they are promising but mostly at the early research phase of discovery.

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CRISPR/Cas9 gene editing: A new therapeutic approach in the treatment of infection and autoimmunity

et al. 2020

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CRISPR/Cas9 (clustered regularly interspaced short palindromic repeats/ CRISPR-associated protein9) may be viewed as an adaptive bacterial immune system. When a virus infects a bacterium, a fragment of the virus genome is inserted into the CRISPR sequence of the bacterial genome as a memory.When the bacterium becomes infected again with the same virus, an RNA molecule that is a transcript of the memory sequence, directs Cas9, an endonuclease, to the complementary region of the virus genome, and Cas9 disables the virus by a double-strand break. In recent years, studies have shown that by designing synthetic RNA molecules and delivering them along with Cas9 into eukaryotic cells, different regions of the cell's genome can be targeted and manipulated. These findings have drawn much attention to this new technology and it has been shown that CRISPR/Cas9 gene editing can be used to treat some human diseases. These include infectious diseases and autoimmune diseases. In this review article, in addition to a brief overview of the biology of the CRISPR/Cas9 system, we collected the most recent findings on the applications of CRISPR/Cas9 technology for better investigation of the pathogenesis and treatment of viral infections (human immunodeficiency virus infection, hepatitis virus infections, and onco-virus infections), non-viral infections (parasitic, fungal, and bacterial infections), and autoimmune diseases.

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Positive Correlation of Fecal Calprotectin With Serum Antioxidant Enzymes in Patients With Inflammatory Bowel Disease: Accidental Numerical Correlation or a New Finding?

Cited by 25 publications

References 19 publications

Inappropriate Total Oxidant/Antioxidant Status, Nitric Oxide Oxidation End Products and Trace Element Levels in Patients with Inflammatory Bowel Disease

Inappropriate Total Oxidant/Antioxidant Status, Nitric Oxide Oxidation End Products and Trace Element Levels in Patients with Inflammatory Bowel Disease

Oxidative Stress Markers in Inflammatory Bowel Diseases: Systematic Review

CRISPR/Cas9 gene editing: A new therapeutic approach in the treatment of infection and autoimmunity

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