Positive affect dimensions and their association with inflammatory biomarkers in patients with chronic heart failure

Brouwers, Corline; Mommersteeg, Paula M.C.; Nyklı́ček, Ivan; Pelle, Aline J.; Westerhuis, Bert L.W.J.J.M.; Szabó, Balázs; Denollet, Johan

doi:10.1016/j.biopsycho.2012.10.002

Cited by 65 publications

(48 citation statements)

References 51 publications

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“…Our study adds to the growing evidence base linking positive psychological factors to lower levels of inflammation (11,13–20). Previous studies have focused on stable psychological characteristics and psychosocial resources (e.g., positive affect and social relations); our study extends these findings by demonstrating the importance of daily events on inflammation.…”

Section: Discussionmentioning

confidence: 63%

“…Emerging evidence suggests that indicators of well-being—such as positive affect, purpose in life, and positive social relations—are associated with lower inflammation (11–18) and less inflammatory reactivity during acute stress tasks (19,20). These associations are independent of, and sometimes stronger than, the effects of negative emotions.…”

Section: Introductionmentioning

confidence: 99%

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Daily positive events and inflammation: Findings from the National Study of Daily Experiences

Sin

Graham‐Engeland

Almeida

2015

Brain, Behavior, and Immunity

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Background Inflammation is implicated in the development of chronic diseases and increases the risk of mortality. People who experience more daily stressors than others have higher levels of inflammation, but it is unknown whether daily positive events are linked to inflammation. Objective To examine the association of daily positive events with 3 inflammatory markers, interleukin-6 (IL-6), C-reactive protein (CRP), and fibrinogen. Method A cross-sectional sample of 969 adults aged 35–86 from the Midlife in the United States Study completed telephone interviews for 8 consecutive evenings. Participants reported positive experiences that occurred over the past 24 hours. Blood samples were obtained at a separate clinic visit and later assayed for inflammatory markers. Regression analyses evaluated the frequency of daily positive events (defined as the percent of study days with at least 1 positive event) as a predictor of each inflammatory marker. Covariates included information on demographics, physical health, depressive symptoms, dispositional and behavioral factors, and daily positive and negative affect. Results On average, participants experienced positive events on 73% of days (SD = 27%). The frequency of daily positive events was associated with lower IL-6 (p < 0.001) and CRP (p = 0.02) in the overall sample, and lower fibrinogen among women (p = 0.01). The association remained for IL-6 in the fully adjusted model, but was no longer significant for CRP and fibrinogen after controlling for household income and race. Effects were more pronounced for participants in the lowest quartile of positive event frequency than for those in the top 3 quartiles, suggesting that lack of positivity in daily life may be particularly consequential for inflammation. Furthermore, interpersonal positive events were more predictive of lower IL-6 overall and lower fibrinogen in women than non-interpersonal positive events. Conclusion Daily positive events may serve a protective role against inflammation.

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Section: Discussionmentioning

confidence: 63%

Section: Introductionmentioning

confidence: 99%

Daily positive events and inflammation: Findings from the National Study of Daily Experiences

Sin

Graham‐Engeland

Almeida

2015

Brain, Behavior, and Immunity

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“…Although there is some conflicting data and some methodological challenges apply [40], most authors agree that individuals with depression and/or anxiety are subject to higher cardiovascular risk [41,42]. Higher burden of classical atherosclerotic disease risk factors [43,44], alterations in platelet function and hypercoagulability [45,46], neuroendocrine changes [47], unbalanced immune responses [48], and disturbances in autonomic [49] and central [50] nervous system functions have all been proposed to explain the higher incidence of cardiovascular events in individuals with depression and/or anxiety. Although some of those mechanisms may be intertwined, measurements of subclinical atherosclerosis, such as CIMT, can help clarify the putative role of accelerated atherosclerosis for the higher cardiovascular risk of individuals with mental disorders.…”

Section: Discussionmentioning

confidence: 97%

Anxiety and depressive symptoms are associated with higher carotid intima-media thickness. Cross-sectional analysis from ELSA-Brasil baseline data

et al. 2015

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“…To avoid over-weighting studies with many similar analyses, 5 or more analyses of the same outcome variable were collapsed into a single analysis, and the analysis was considered to be significant when half or more of the total analyses had significant associations; this was done for four studies [31–34] that performed a total of 60 analyses. If we had not collapsed these analyses, these four studies (composed of n=860 participants) would have accounted for nearly half of all analyses across the 30 total examined studies (N=14,624).…”

Section: Methodsmentioning

confidence: 99%

Relationships between positive psychological constructs and health outcomes in patients with cardiovascular disease: A systematic review

DuBois

Lopez

Beale

et al. 2015

International Journal of Cardiology

143

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Depression and anxiety are well-known to be associated with adverse health outcomes in cardiac patients. However, there has been less work synthesizing the effects of positive psychological constructs (e.g., optimism) on health-related outcomes in cardiac patients. We completed a systematic review of prospective observational studies using established guidelines. A search of PubMed and PsycINFO databases from inception to January 2014 was used to identify articles. To be eligible, studies were required to assess effects of a positive psychological construct on subsequent health-related outcomes (including mortality, rehospitalizations, self-reported health status) in patients with established heart disease. Exploratory random effects meta-analyses were performed on the subset of studies examining mortality or rehospitalizations. Seventy-seven analyses from 30 eligible studies (N=14,624) were identified. Among studies with 100 or more participants, 65.0% of all analyses and 64.7% of analyses adjusting for one or more covariates reported a significant (p<.05) association between positive psychological constructs and subsequent health outcomes. An exploratory meta-analysis of 11 studies showed that positive constructs were associated with reduced rates of rehospitalization or mortality in unadjusted (odds ratio=.87; 95% confidence interval [.83, .92]; p<.001) and adjusted analyses (odds ratio=.89; 95% confidence interval [.84, .91]; p<.001); there was little suggestion of publication bias. Among cardiac patients, positive psychological constructs appear to be prospectively associated with health outcomes in most but not all studies. Additional work is needed to identify which constructs are most important to cardiac health, and whether interventions can cultivate positive attributes and improve clinical outcomes.

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Positive affect dimensions and their association with inflammatory biomarkers in patients with chronic heart failure

Cited by 65 publications

References 51 publications

Daily positive events and inflammation: Findings from the National Study of Daily Experiences

Daily positive events and inflammation: Findings from the National Study of Daily Experiences

Anxiety and depressive symptoms are associated with higher carotid intima-media thickness. Cross-sectional analysis from ELSA-Brasil baseline data

Relationships between positive psychological constructs and health outcomes in patients with cardiovascular disease: A systematic review

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