Anxiety and depressive symptoms are associated with higher carotid intima-media thickness. Cross-sectional analysis from ELSA-Brasil baseline data

Santos, Itamar S.; Goulart, Alessandra Carvalho; Brunoni, André R.; Kemp, Andrew H.; Lotufo, Paulo A.

doi:10.1016/j.atherosclerosis.2015.04.800

Cited by 40 publications

(29 citation statements)

References 62 publications

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“…For instance, a recent large‐scale meta‐analysis of over 3 million patients showed that patients with severe mental illness, including schizophrenia, bipolar disorder, and depression, present a significantly increased risk of CVD, such as coronary heart disease, cerebrovascular disease, and congestive heart failure, and CVD‐related mortality . The association between depression, CVD, and CVD mortality might be mediated by several biological and behavioral mechanisms and risk factors, such as sedentary behavior , poor adherence to lifestyle changes and clinical treatment , decreased heart rate variability, higher coronary artery calcium scores, higher intima‐media thickness , and a higher prevalence of coronary heart disease .…”

Section: Discussionmentioning

confidence: 99%

Association between ideal cardiovascular health and depression incidence: a longitudinal analysis of ELSA‐Brasil

Brunoni

Szlejf

Suemoto

et al. 2019

Acta Psychiatr Scand

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IM. Association between ideal cardiovascular health and depression incidence: a longitudinal analysis of ELSA-Brasil.Objective: We investigated whether ideal cardiovascular health (ICH), a metric proposed by the American Heart Association, predicts depression development. Methods: Cohort analysis from the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil). Adults with no current depression and other common mental disorders, cardiovascular diseases, and antidepressant drug use at baseline had their ICH (composite score of smoking, dietary habits, body mass index, blood pressure, fasting glucose, cholesterol, and physical activity) assessed and classified into poor, intermediate, and optimal. Depression was assessed using the Clinical Interview Schedule-Revised (CIS-R). Poisson regression models, adjusted for sociodemographic factors and alcohol consumption, were employed. Stratified analyses were performed for age and sex. Results: We included 9214 participants (mean age 52 AE 9 years, 48.6% women). Overall depression incidence at 3.8-year follow-up was 1.5%. Intermediate and poor ICH significantly increased the risk rate (RR) of developing depression (2.48 [95%CI 1.06-5.78] and 3 [1.28-7.03], respectively) at a 3.8-year follow-up. Higher ICH scores decreased the rate of depression development (RR = 0.84 [0.73-0.96] per metric). Stratified analyses were significant for women and adults < 55 years old. Conclusions: Poor cardiovascular health tripled depression risk at follow-up in otherwise healthy adults. Ameliorating cardiovascular health might decrease depression risk development. Significant outcomes• Poor cardiovascular health predicts depression incidence in subjects free of mental and cardiovascular disorders.• These effects are more pronounced in women and in subjects younger than 55 years old. • Decreasing cardiovascular risk can impact in both clinical and mental outcomes. Limitations• The follow-up period was relatively small (3.8 years).• Other common mental disorders were not examined. 552

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Section: Discussionmentioning

confidence: 99%

Association between ideal cardiovascular health and depression incidence: a longitudinal analysis of ELSA‐Brasil

Brunoni

Szlejf

Suemoto

et al. 2019

Acta Psychiatr Scand

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“…Much like depression, anxiety is a negative prognostic factor in CVD, increasing the risk of recurrent infarctions, cardiac arrests, and deaths [5,6]. Higher anxiety and depression scores are associated with higher carotid intima-media thickness values in patients without previous coronary heart disease (CHD) [7], suggesting that the association is present in subclinical psychiatric and cardiac conditions. This cardiopsychiatric comorbidity has a high social burden considering that anxiety disorders are among the most common psychiatric conditions [3,8] and that CVD is the most common cause of mortality in many countries [9].…”

mentioning

confidence: 99%

Descriptive Study of Anxiety and Posttraumatic Stress Disorders in Cardiovascular Disease Patients: From Referral to Cardiopsychiatric Diagnoses

Long

Guertin²,

Dyrda

et al. 2018

Psychother Psychosom

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“…Study limitations are the cross‐sectional design, which precludes making conclusions regarding the direction of cause and effect. Also, we did not assess psychological factors, such as anxiety or depression and their potential impact on the study findings . Indeed, emerging evidence suggests the potential contribution of improved psychological health to better population‐level cardiovascular health .…”

Section: Discussionmentioning

confidence: 99%

Dietary intake of isoflavones is associated with a lower prevalence of subclinical cardiovascular disease in postmenopausal women: cross‐sectional study

Ferreira

Silva

Maturana³

et al. 2019

J Human Nutrition Diet

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Background: Menopause has been associated with an increased risk of cardiovascular disease. It has been shown that isoflavones protect vascular endothelial cells against induced oxidative stress injury. Therefore, the present study aimed to investigate the association between the dietary intake of isoflavones and the presence of subclinical cardiovascular disease (CVD) in postmenopausal women. Methods: Ninety-six postmenopausal women [mean (SD) age 55.2 (4.9) years, body mass index (BMI) 27.2 (4.6) kg m À2 ] completed the study protocol. Habitual physical activity was assessed using a digital pedometer, resting metabolic rate was measured by indirect calorimetry and dietary intake was assessed via a validated food frequency questionnaire. Subclinical CVD was defined as carotid artery intima-media thickness (C-IMT) >0.9 mm and/or the presence of one or more atherosclerotic plaques in any of the studied segments. Results: Mean (SD) C-IMT was 0.74 (0.2) mm, 25% of participants were found to have atherosclerotic plaques and the prevalence of subclinical CVD was 35%. Participants with subclinical CVD were more likely to consume less selenium, magnesium, folate and isoflavones, even after adjusting for total energy intake. A multivariate-adjusted regression model showed that a BMI >27 kg m -2 was associated with 90% higher risk of having ≥1 plaque and/or C-IMT >0.9 mm (P = 0.017). Higher oestradiol levels (P = 0.004) and isoflavone intake (P = 0.021) were independently associated with a lower risk of having subclinical CVD. Conclusions: In the present study, we observed that a higher isoflavone dietary intake was associated with a lower risk of subclinical CVD in postmenopausal women, independent of BMI and endogenous oestradiol levels.810

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Anxiety and depressive symptoms are associated with higher carotid intima-media thickness. Cross-sectional analysis from ELSA-Brasil baseline data

Cited by 40 publications

References 62 publications

Association between ideal cardiovascular health and depression incidence: a longitudinal analysis of ELSA‐Brasil

Association between ideal cardiovascular health and depression incidence: a longitudinal analysis of ELSA‐Brasil

Descriptive Study of Anxiety and Posttraumatic Stress Disorders in Cardiovascular Disease Patients: From Referral to Cardiopsychiatric Diagnoses

Dietary intake of isoflavones is associated with a lower prevalence of subclinical cardiovascular disease in postmenopausal women: cross‐sectional study

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