Dietary intake of isoflavones is associated with a lower prevalence of subclinical cardiovascular disease in postmenopausal women: cross‐sectional study

Ferreira, L. L.; Silva, T. R.; Maturana, Maria Augusta; Spritzer, Poli Mara

doi:10.1111/jhn.12683

Cited by 11 publications

(7 citation statements)

References 57 publications

(69 reference statements)

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“…These results are reasonable, because it is known that bioavailability of epicatechin and isoflavones is relatively higher than that of C3G and procyanidins [ 33 , 34 ], indicating that epicatechin and isoflavones in black soybean are considerable active compounds for the improvement of vascular function though possessing their antioxidant activity. It is known that soy isoflavones improves vascular functions [ 35 , 36 ]. Interestingly, certain amounts of isoflavones were detected as their aglycone forms in plasma and urine in this study.…”

Section: Discussionmentioning

confidence: 99%

Black Soybean Improves Vascular Function and Blood Pressure: A Randomized, Placebo Controlled, Crossover Trial in Humans

Yamashita

Nakamura

Nanba³

et al. 2020

Nutrients

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Vascular dysfunction and injurious stimuli such as oxidative stress are closely related to the risk of cardiovascular diseases (CVD). Dietary polyphenols are reported to exert beneficial effects in reducing the risk of CVD. Black soybean has been used as a nutritionally rich food and contains abundant polyphenols in its seed coat and grain. Black soybean has many beneficial physiological activities, and its prevention effects on CVD risk were reported mainly in animal experiments. In this study, we performed a randomized, single blind, placebo controlled, crossover trial to investigate the effect of black soybean consumption on the vascular function in healthy humans. Twenty-two healthy adults aged from 30 to 60 completed the four week trial with daily consumption of about a 40 g test material cookie containing 20 g roasted black soybean powder. Body composition, vascular function, biomarkers for oxidative stress, and polyphenol contents in the urine and the plasma were measured. After ingestion of the black soybean cookie, vascular function, which was evaluated by plethysmogram using a Pulse Analyzer®, was improved and systolic blood pressure was decreased. Moreover, nitric oxide levels in plasma and urine were increased, while an oxidative stress biomarker, 8-hydroxy-2′-deoxyguanosine level, in the plasma was decreased accompanied by an increase in the concentration of polyphenols derived from black soybean in plasma and urine. These results suggest that the antioxidant activity of black soybean polyphenols and an increase in the nitric oxide level may contribute to the improvement of vascular function. Thus, black soybean is an attractive food material for improvement of vascular function through decreasing oxidative stress by its potent antioxidant activity and increasing the nitric oxide level in healthy humans.

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Section: Discussionmentioning

confidence: 99%

Black Soybean Improves Vascular Function and Blood Pressure: A Randomized, Placebo Controlled, Crossover Trial in Humans

Yamashita

Nakamura

Nanba³

et al. 2020

Nutrients

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“…A positive relationship has been found between isoflavone intake, endothelial function and reduced lower carotid atherosclerotic burden [ 161 ]. Ferreira and colleagues also found that higher isoflavone intake was independently associated with lower risk for subclinical CVD in menopausal women [ 162 ]. Results from experimental studies using phytoestrogens for CVD prevention and treatment have been mixed, but generally positive.…”

Section: Phytoestrogensmentioning

confidence: 99%

Is There Such a Thing as “Anti-Nutrients”? A Narrative Review of Perceived Problematic Plant Compounds

2020

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Plant-based diets are associated with reduced risk of lifestyle-induced chronic diseases. The thousands of phytochemicals they contain are implicated in cellular-based mechanisms to promote antioxidant defense and reduce inflammation. While recommendations encourage the intake of fruits and vegetables, most people fall short of their target daily intake. Despite the need to increase plant-food consumption, there have been some concerns raised about whether they are beneficial because of the various ‘anti-nutrient’ compounds they contain. Some of these anti-nutrients that have been called into question included lectins, oxalates, goitrogens, phytoestrogens, phytates, and tannins. As a result, there may be select individuals with specific health conditions who elect to decrease their plant food intake despite potential benefits. The purpose of this narrative review is to examine the science of these ‘anti-nutrients’ and weigh the evidence of whether these compounds pose an actual health threat.

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“…In addition, we recently reported higher isoflavone dietary intake may be associated with lower risk of subclinical CVD, as assessed by CCA-IMT status, independently of endogenous estradiol levels and BMI [ 94 ]. Isoflavones might have beneficial effects by its anti-inflammatory and antioxidant properties, through the production of equol, an active metabolite formed from daidzin/daidzein by gut microbiota [ 95 ].…”

Section: Dietary Intake and Clinical Endpoints In Menopausal Womenmentioning

confidence: 99%

Nutrition in Menopausal Women: A Narrative Review

et al. 2021

Self Cite

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Among the various aspects of health promotion and lifestyle adaptation to the postmenopausal period, nutritional habits are essential because they concern all women, can be modified, and impact both longevity and quality of life. In this narrative review, we discuss the current evidence on the association between dietary patterns and clinical endpoints in postmenopausal women, such as body composition, bone mass, and risk markers for cardiovascular disease. Current evidence suggests that low-fat, plant-based diets are associated with beneficial effects on body composition, but further studies are needed to confirm these results in postmenopausal women. The Mediterranean diet pattern along with other healthy habits may help the primary prevention of bone, metabolic, and cardiovascular diseases in the postmenopausal period. It consists on the use of healthy foods that have anti-inflammatory and antioxidant properties, and is associated with a small but significant decrease in blood pressure, reduction of fat mass, and improvement in cholesterol levels. These effects remain to be evaluated over a longer period of time, with the assessment of hard outcomes such as bone fractures, diabetes, and coronary ischemia.

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Dietary intake of isoflavones is associated with a lower prevalence of subclinical cardiovascular disease in postmenopausal women: cross‐sectional study

Cited by 11 publications

References 57 publications

Black Soybean Improves Vascular Function and Blood Pressure: A Randomized, Placebo Controlled, Crossover Trial in Humans

Black Soybean Improves Vascular Function and Blood Pressure: A Randomized, Placebo Controlled, Crossover Trial in Humans

Is There Such a Thing as “Anti-Nutrients”? A Narrative Review of Perceived Problematic Plant Compounds

Nutrition in Menopausal Women: A Narrative Review

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