Position Calibration of a Single Cell Measurement With Electrochemical Impedance Spectroscopy

Wan, Jing; Yang, Lu; Hu, Songpei; Li, Kai; Jia, Jiabin; Yao, Jiafeng

doi:10.1109/jsen.2021.3113076

Cited by 4 publications

(1 citation statement)

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“…The relative position of particles passing through the detection area between electrode pairs has great effects on the detection stability and repeatability, especially in coplanar electrode design [ 37 , 55 , 56 ]. Except for reducing the cross-sectional area of the channel, constriction channels and various methods of focusing particles have been proposed in order to obtain higher impedance signal quality.…”

Section: Device Designs For Sensing Single-cell Impedancementioning

confidence: 99%

Recent Advances in Electrical Impedance Sensing Technology for Single-Cell Analysis

et al. 2021

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Cellular heterogeneity is of significance in cell-based assays for life science, biomedicine and clinical diagnostics. Electrical impedance sensing technology has become a powerful tool, allowing for rapid, non-invasive, and label-free acquisition of electrical parameters of single cells. These electrical parameters, i.e., equivalent cell resistance, membrane capacitance and cytoplasm conductivity, are closely related to cellular biophysical properties and dynamic activities, such as size, morphology, membrane intactness, growth state, and proliferation. This review summarizes basic principles, analytical models and design concepts of single-cell impedance sensing devices, including impedance flow cytometry (IFC) to detect flow-through single cells and electrical impedance spectroscopy (EIS) to monitor immobilized single cells. Then, recent advances of both electrical impedance sensing systems applied in cell recognition, cell counting, viability detection, phenotypic assay, cell screening, and other cell detection are presented. Finally, prospects of impedance sensing technology in single-cell analysis are discussed.

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Section: Device Designs For Sensing Single-cell Impedancementioning

confidence: 99%