Porphyrin‐based, light‐activated antimicrobial materials

Bozja, Jadranka; Sherrill, Jennifer; Michielsen, Stephen; Stojiljković, Igor

doi:10.1002/pola.10773

Cited by 96 publications

(73 citation statements)

References 23 publications

(28 reference statements)

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“…Porphyrins located in a sol-gel matrix have also been used for pH sensing [34]. Use of porphyrin-loaded polymers in PDT has been confined to either development of nanomaterials for delivery [35] or systems aimed, ultimately, at water purification [36][37][38], with few other references in the literature to porphyrin-impregnated surfaces for use as photobactericidal agents [39][40][41]. It was in this context that p(HEMA-co-MAA) hydrogels were selected for investigation as the polymer hosts for the described porphyrin technology; MAA was included as an anionic polymer at neutral pH to interact strongly with cationic TMPyP.…”

Section: Discussionmentioning

confidence: 99%

Anti-infective photodynamic biomaterials for the prevention of intraocular lens-associated infectious endophthalmitis

et al. 2009

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Section: Discussionmentioning

confidence: 99%

Anti-infective photodynamic biomaterials for the prevention of intraocular lens-associated infectious endophthalmitis

et al. 2009

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“…The first antimicrobial porphyrin textiles were reported by Bozja et al [73], named as light-activated antimicrobial materials. Novel materials were synthesized by the grafting of PPIX and zinc protoporphyrin IX (Zn(II)-PPIX) to nylon fibers and their antimicrobial effectiveness tested against S. aureus and E. coli.…”

Section: Porphyrin-embedded Fabricmentioning

confidence: 99%

“…The zinc samples were more effective than the corresponding free-base. With suitable changes, these materials have been suggested to be used for privacy curtains in hospital rooms, laboratory coats for medical personnel, or other fiber or plastic surfaces within the hospital environment considering that the normal rooms' illumination is approximately 30,000 lx [73].…”

Section: Porphyrin-embedded Fabricmentioning

confidence: 99%

Potential applications of porphyrins in photodynamic inactivation beyond the medical scope

Alves

Faustino

Neves

et al. 2015

Journal of Photochemistry and Photobiology C: Photochemistry Re

191

122

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a b s t r a c tAlthough the discovery of light-activated antimicrobial agents had been reported in the 1900s, only more recently research work has been developed toward the use of photodynamic process as an alternative to more conventional methods of inactivation of micro(organisms). The photoprocess causes cell death through irreversible oxidative damage by reactive oxygen species produced by the interaction between a photosensitizing compound and a light source.With great emphasis on the environmental area, photodynamic inactivation (PDI) has been tested in insect eradication and in water disinfection. Lately, other studies have been carried out concerning its possible use in aquaculture waters or to the control of food-borne pathogens. Other potential applications of PDI in household, industrial and hospital settings have been considered.In the last decade, scientific research in this area has gained importance not only due to great developments in the field of materials chemistry but also because of the serious problem of the increasing number of bacterial species resistant to common antibiotics. In fact, the design of antimicrobial surfaces or selfcleaning materials is a very appealing idea from the economic, social and public health standpoints. Thus, PDI of micro(organisms) represents a promising alternative.In this review, the efforts made in the last decade in the investigation of PDI of (micro)organisms with potential applications beyond the medical field will be discussed, focusing on porphyrins, free or immobilized on solid supports, as photosensitizing agents.

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“…For example, it takes approximately 1 × 10 5 S. aureus to cause illness. A reduction in the number of organisms below this level prevents infection [73].…”

Section: Acrylicmentioning

confidence: 99%

Recent Developments in Finishing of Synthetic Fibers for Medical Applications

El-Ola

2008

Designed Monomers and Polymers

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Demand for antimicrobial fabrics has grown significantly in recent years because of public awareness of the potential threat of spreading diseases and there will be an increasing role for medical textiles in the future world market. The number of applications of polymeric materials for medical purposes is growing very fast. Polymers have found applications in such diverse biomedical fields as tissue engineering, implantation of medical devices and artificial organs, prostheses, ophthalmology, dentistry, bone repair and many other medical fields. Polymer-based delivery systems enable controlled release of drugs into the body. The aim of the present review is to clarify the antimicrobial agents and their mechanism of action, test methods, and the recent developments in antimicrobial functional finishing of synthetic fibers for medical applications (commercially available bioactive fibers).

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Porphyrin‐based, light‐activated antimicrobial materials

Cited by 96 publications

References 23 publications

Anti-infective photodynamic biomaterials for the prevention of intraocular lens-associated infectious endophthalmitis

Anti-infective photodynamic biomaterials for the prevention of intraocular lens-associated infectious endophthalmitis

Potential applications of porphyrins in photodynamic inactivation beyond the medical scope

Recent Developments in Finishing of Synthetic Fibers for Medical Applications

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