Porous calcium carbonate microparticles as templates for encapsulation of bioactive compounds

Biocompatible polypeptide microcapsules via templating mesoporous silica spheres

“…The extension of the LbL method to colloidal particles and the subsequent removal of the template core has led to a viable alternative for preparing hollow capsules with controlled composition, wall thickness and size [3][4][5], which are of great usefulness in the encapsulation of functional materials [5,6]. More recently, the method has also been extended to the coating of multilayer films onto porous particles [7][8][9][10]. For example, by employing interlayer cross-linking, multilayer films of polyelectrolytes (PEs) were successfully deposited into the pores of mesoporous silica spheres, which provides an effective way to prepare nanoporous solid PE spheres with controlled diameter and excellent capacity for immobilizing biomolecules [7].…”

“…Sukhorukov and co-workers demonstrated that LbL coating of porous inorganic microparticles of calcium carbonate followed by core removal resulted in the matrix polyelectrolyte microcapsules which also have good capability of loading macromolecules [9,10].…”

Polymeric multilayer capsules delivering biotherapeutics

“…An alternative to HF are calcium carbonate microparticles (CaC0 3 ) [16] which are formed through mixing of calcium chloride and sodium carbonate. After LbL coating the CaCO 3 particles are easily dissolved in an aqueous EDTA solution.…”

“…For this purpose, emulsions [10,11] are used to encapsulate hydrophobic compounds -these are dissolved into an organic phase which is subsequently coated with a multilayer film -while porous inorganic templates can adsorb both hydrophilic as well as hydrophobic molecules in their pores. Mesoporous silica (SiO 2 ) [12][13][14] and calcium carbonate (CaCO 3 ) [15][16][17][18] microparticles have been used for this purpose. Mesoporous silica (Figure 2) benefits from the advantage that such templates can be obtained in a monodisperse state and that they are stable over the whole pH range which allows the use of polyelectrolyte solutions with acidic pH.…”

Electrodeposition CaCO3 Nanoparticles‐chitosan Composite Film on Carbon Ionic Liquid Electrode as a Platform for Hemoglobin Electrochemical Biosensor

“…Shan et al 12 reported the combination between nanoCaCO 3 and chitosan for the entrapment of hemoglobin, and the resulting CaCO 3 /chi nanocomponents showed enhanced electron transfer, higher thermal stability and better electrocatalytic activity. Sukhorukov et al 13 used 30-50 nm porous CaCO 3 as templates for the encapsulation of bioactive compounds. Hu et al 14 also constructed a core-shell nanocluster film with the layer-by-layer method containing heme proteins, nanoCaCO 3 , and polyelectrolytes.…”