Polymeric multilayer capsules delivering biotherapeutics

Koker, Stefaan De; Cock, Liesbeth J. De; Rivera-Gil, Pilar; Parak, Wolfgang J.; Velty, Rachel Auzély; Vervaet, Chris; Remon, Jean Paul; Grooten, Johan; Geest, Bruno G. De

doi:10.1016/j.addr.2011.03.014

Cited by 149 publications

(112 citation statements)

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“…A further domain of polymers is the field of spatiotemporal control of different drug delivery processes (De Koker et al, 2011a, De Koker et al, 2011b, Costache et al, 2009. Polymer libraries do exist for individual requirements concerning degradation time and characteristics, encapsulation capacity and stability (Place et al, 2009b).…”

Section: Polymer-based Bone Graft Substitutesmentioning

confidence: 99%

Current trends and future perspectives of bone substitute materials – From space holders to innovative biomaterials

Kolk

Handschel

Drescher

et al. 2012

Journal of Cranio-Maxillofacial Surgery

379

314

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Section: Polymer-based Bone Graft Substitutesmentioning

confidence: 99%

Current trends and future perspectives of bone substitute materials – From space holders to innovative biomaterials

Kolk

Handschel

Drescher

et al. 2012

Journal of Cranio-Maxillofacial Surgery

379

314

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“…[ 1,2 ] Among other various approaches, encapsulation into optimized particles is opening new opportunities. In general terms, encapsulation is the process to confi ne bioactive agents into a matrix, generally in a particulate form, in order to confer protection, control the release and even target the molecules to the site of action.…”

mentioning

confidence: 99%

Design Advances in Particulate Systems for Biomedical Applications

Lima

Álvarez-Lorenzo

Mano

2016

Adv Healthcare Materials

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Particulate systems have been widely used as containers of drugs or cells with the purpose of releasing them in a particularThe search for more effi cient therapeutic strategies and diagnosis tools is a continuous challenge. Advances in understanding the biological mechanisms behind diseases and tissues regeneration have widened the fi eld of applications of particulate systems. Particles are no more just protective systems for the encapsulated drugs, but they play an active role in the success of the therapy. Moreover, particles have been explored for innovative purposes as templates for cells growth and as diagnostic tools. Until few years ago the most relevant parameters in particles formulation were the chemistry and the size. Currently, it is known that other physical characteristics can remarkably affect the performance of particulate systems. Particles with non-conventional shapes exhibit advantages due to the increasing circulation time in blood stream, less clearance by the immune system and more effi cient cell internalization and traffi cking. Creation of compartments has been found useful to control drug release, to tune the transport of substances across biological barriers, to supply the target with more than one bioactive agent or even to act as theranostic systems. It is expected that such complex shaped and compartmentalized systems improve the therapeutic outcomes and also the patient's compliance, acting as advanced devices that serve for simultaneous diagnosis and treatment of the disease, combining agents of very different features, at the same time. In this review, we overview and analyse the most recent advances in particle shape and compartmentalization and applications of newly designed particulate systems in the biomedical fi eld.

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“…Due to the inherent properties of DNA as a natural biological compound, multilayers containing DNA have been investigated for their possibility of providing relatively low-immunogenic coatings [3] and surface-mediated cell transfection on various substrates [4][5][6][7]. Multilayers containing a top DNA layer have shown a significant increase in primary rat dermal fibroblast proliferation as compared to non-coated glass surfaces in vitro, while in vivo tissue response studies also showed that the DNA-coatings are histocompatible without showing signs of inflammation or adverse reactions [3].…”

Section: Introductionmentioning

confidence: 99%