Porosity of the Placenta to Maternal Cells in Normal Derived Mice

Transplacental passage of blood cells.

“…A chromosome marker (TB) was used to differentiate between maternal and fetal mitoses. Similar observations were later reported by the same authors (Tuffrey et al, 1969b) after normal pregnancies, in which they used matings between CFW and CBA T6T6 mice. However, Billington et al (1969) were unable to confirm these results, and suggested that the findings of Tuffrey et al (1969a;1969b) might be due to misinterpretation of the T6 marker.…”

“…In the mouse maternal erythrocytes and lymphocytes have also been demonstrated in the circulation of the offspring by several different methods (Finegold and Michie, 1961;Tuffrey et al, 1969a;1969b; Barnes and Tuffrey, 1970).…”

“…The passage of blood cells has been studied in detail in the mouse (Finegold and Michie, 1961;Billington et al, 1969;Tuffrey et al, 1969a;1969b; Barnes and Tuffrey, 1970;Seller, 1970), but the question is so far unanswered. However, these studies involved the use of cytological markers.…”

Review article

“…These antigen reactive cells cross the placenta and attack the fetus. Close scrutiny of infants who fail to thrive and who also present Symptoms resembling those of experimentally procurred runt disease in animals, has produced a few cases of natural maternally induced runt disease, some even documented by evidence of lymphocyte chimerism [52,100]. It is also possible that a significant proportion of the fetuses that die in utero of unknown causes have also been the victims of Infiltration by their mother's lymphocytes.…”

Immunity: Host Response

“…This has been noted previously by Bruce-Chwatt; (32a) "In the light of recent discoveries in the field of 'immunological tolerance,' it might be useful to emphasize the special relationship between the mammalian mother and its unborn young and to attempt to increase our still too meagre knowledge of congenital immunity to protozoan diseases generally and to malaria in particular." This could, at least in theory, arise from antigenic stimulation of the foetus or be derived from sensitised cells acquired from the mother (35). In spite of this it is frequently observed that young animals born in endemic areas of, for example, malaria, babesia or Theileria are usually relatively resistant to such infections (30)(31)(32)(33)(34).…”