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Summary . Immunoglobulins (IgG, IgM and IgA) were estimated in sera from mothers and siblings of children with acute lymphoblastic leukaemia (ALL) and in sera from appropriate controls. The distribution of IgA titres was significantly lower in the siblings of leukaemic children than in control children and that of IgM was significantly higher in mothers of leukaemic children than in control mothers.

The effect of vitamin C on cell proliferation and DNA synthesis was investigated using two tumor cell lines Hep₂ and KB. The results show that there was an increase in the ratio of dead to live cells and a decrease in the rate of DNA synthesis. The results also agree with other work carried out on animal experimental models which claimed that vitamin C may be involved in the arrest of neoplastic cell proliferation.

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