Porang Glucomannan Supplementation Improves Lipid Profile in Metabolic Syndrome Induced Rats

Safitri, Azizah Hikma; Tyagita, Nurina; Nasihun, Taufiqurrachman

doi:10.18311/jnr/2017/18125

Cited by 4 publications

(8 citation statements)

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“…The presence of insoluble fibre and the formation of a thick gel by glucomannan contributed to the delay in gastric emptying, prolonged satiety, and subsequent reduction in body weight among adults with overweight or obese. 7,8 According to the European Food Safety Authority (EFSA), consuming 3 g of glucomannan in divided doses can effectively reduce body weight in overweight adults. Fasting blood glucose (FBG) levels in rats supplemented with porang glucomannan at a dose of 100 mg/200 g BW exhibited a similar trend to the average body weight and was significantly different compared to the normal group.…”

Section: Resultsmentioning

confidence: 99%

“…Porang glucomannan, also known as Amorphophallus muelleri Blume, is an indigenous tuber commonly found in Indonesia. It shares a similar soluble fibre structure 7 to konjac glucomannan, which is prevalent in Japan, Korea, and China. 8 Previous research have demonstrated that supplementation with konjac glucomannan at a dosage of 3 g/day has a positive impact on reducing body weight in adults who are overweight or obese.…”

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confidence: 99%

“…8 Previous research have demonstrated that supplementation with konjac glucomannan at a dosage of 3 g/day has a positive impact on reducing body weight in adults who are overweight or obese. 7,9,10 Glucomannan possesses a structure that resists breakdown by salivary amylase and pancreatic amylase enzymes, making it susceptible to fermentation by bacteria in the colon. 7,11 This fermentation process converts glucomannan into a prebiotic substance that benefits pancreatic beta cells and insulin activity.…”

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confidence: 99%

“…7,9,10 Glucomannan possesses a structure that resists breakdown by salivary amylase and pancreatic amylase enzymes, making it susceptible to fermentation by bacteria in the colon. 7,11 This fermentation process converts glucomannan into a prebiotic substance that benefits pancreatic beta cells and insulin activity. 12 Long-term supplementation with konjac glucomannan has been shown to lower blood glucose © 2023 the authors.…”

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confidence: 99%

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Enhancing Metabolic Parameters: The Impact of Porang Glucomannan on Body Weight, Intraperitoneal Fat, Fasting Blood Glucose, and GLUT-4 Levels in Rats Fed a High-Fat and High-Carbohydrate Diet

2023

TJNPR

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The composition of high-fat and high-carbohydrate (HFHC) diet is closely associated with metabolic syndrome, 1 a condition characterized by a cluster of symptoms affecting the cardiometabolic system. These symptoms include central obesity, hyperglycemia, hypertension, and dyslipidemia. 1 The primary causes of metabolic syndrome are the consumption of high-calorie diet and insufficient physical activity. 2 Metabolic syndrome has become a global concern due to its increasing prevalence and numerous complications. According to data from the American Heart Association Journal (AHA), the prevalence of metabolic syndrome in Asia has risen to 25.8% of the total population and continues to grow. In Indonesia, the occurrence of metabolic syndrome is also on the rise, along with an increased risk of obesity and weight gain. The prevalence of metabolic syndrome in Indonesia is reported to be 39.0% in 2020. 3 Among the Indonesian population, metabolic syndrome affects 14.3% of the elderly, with higher prevalence in women than men. 4 The escalating occurrence of metabolic syndrome in society necessitates effective treatment approaches. Besides lifestyle modification and drug consumption, metabolic syndrome can be solved with natural ingredient consumption as therapy or functional food, such as porang glucomannan.

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Section: Resultsmentioning

confidence: 99%

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confidence: 99%

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confidence: 99%

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Enhancing Metabolic Parameters: The Impact of Porang Glucomannan on Body Weight, Intraperitoneal Fat, Fasting Blood Glucose, and GLUT-4 Levels in Rats Fed a High-Fat and High-Carbohydrate Diet

2023

TJNPR

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“…Additionally, glucomannan functions as a prebiotic, aiding in synthesizing GLP-1 and short-chain fatty acid biosynthesis. Lipid synthesis will eventually decline as a result of this process' impact on lipid metabolism [10].…”

Section: Introductionmentioning

confidence: 99%

Glucomannan from Porang (Amorphophallus muelleri) Improves Short-Chain Fatty Acid in Wistar Rat with High-Fat and High-Fructose Diet

Harimawan

2024

Babali Nurs. Res.

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Introduction: Short-chain fatty acids (SCFAs) improve lipid profile and prevent coronary artery disease. Searching for nutrition based on local foods that might raise the body's SCFA levels is imperative. Porang (Amorphophallus muelleri) is a plant with a high concentration of glucomannan that is investigated to have a healthy benefit. This study aimed to investigate the effect of glucomannan from Porang (A.muelleri) on SCFA in Wistar rats with a high-fat, high-fructose diet.Methods: This was an experimental study with a randomized and post-test-only control group design. Thirty male Wistar rats were divided into five groups: a normal control group, a negative control group given a high-fat, high-fructose diet, and treatment groups given Porang glucomannan 25mg, 50mg, or 100mg/200gBW. Twenty-eight days after the intervention, the SCFA level was measured using gas chromatography–masstry (GC/MS). Data were analyzed in SPSS.Results: The treatment group with Porang glucomannan 50 mg/200gBW has the highest mean SCFA level (3.98±0.83 nmol/ml) compared to normal control (1.56±0.24), negative control (2.18±0.45), treatment group 25mg/200gBW (1.81±0.26), and treatment group 100mg/200gBW (2.58±0.38). Kruskal Wallis test showed significant differences among groups (p<0.001). Post hoc test revealed that SCFA in the treatment group 50 mg was significantly higher than the normal control and negative control group.Conclusion: Glucomannan from Porang (A.muelleri) at 50 mg/200gBW doses improves short-chain fatty acid in Wistar rats with high-fat and high-fructose diets.

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Genus Amorphophallus: A Comprehensive Overview on Phytochemistry, Ethnomedicinal Uses, and Pharmacological Activities

Islam,

Labib,

Zehravi

et al. 2023

Plants

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The genus Amorphophallus belongs to the family Araceae. Plants belonging to this genus are available worldwide and have been used in traditional medicines since ancient times, mainly in Ayurveda and Unani medical practices. Amorphophallus species are an abundant source of polyphenolic compounds; these are accountable for their pharmacological properties, such as their analgesic, neuroprotective, hepatoprotective, anti-inflammatory, anticonvulsant, antibacterial, antioxidant, anticancer, antiobesity, and immunomodulatory effects, as well as their ability to prevent gastrointestinal disturbance and reduce blood glucose. Moreover, Amorphophallus species contain numerous other classes of chemical compounds, such as alkaloids, steroids, fats and fixed oils, tannins, proteins, and carbohydrates, each of which contributes to the pharmacological effects for the treatment of acute rheumatism, tumors, lung swelling, asthma, vomiting, abdominal pain, and so on. Additionally, Amorphophallus species have been employed in numerous herbal formulations and pharmaceutical applications. There has been no extensive review conducted on the Amorphophallus genus as of yet, despite the fact that several experimental studies are being published regularly discussing these plants’ pharmacological properties. So, this review discusses in detail the pharmacological properties of Amorphophallus species. We also discuss phytochemical constituents in the Amorphophallus species and their ethnomedicinal uses and toxicological profiles.

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Porang Glucomannan Supplementation Improves Lipid Profile in Metabolic Syndrome Induced Rats

Cited by 4 publications

References 35 publications

Enhancing Metabolic Parameters: The Impact of Porang Glucomannan on Body Weight, Intraperitoneal Fat, Fasting Blood Glucose, and GLUT-4 Levels in Rats Fed a High-Fat and High-Carbohydrate Diet

Enhancing Metabolic Parameters: The Impact of Porang Glucomannan on Body Weight, Intraperitoneal Fat, Fasting Blood Glucose, and GLUT-4 Levels in Rats Fed a High-Fat and High-Carbohydrate Diet

Glucomannan from Porang (Amorphophallus muelleri) Improves Short-Chain Fatty Acid in Wistar Rat with High-Fat and High-Fructose Diet

Genus Amorphophallus: A Comprehensive Overview on Phytochemistry, Ethnomedicinal Uses, and Pharmacological Activities

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