Population Differences in Breast Cancer: Survey in Indigenous African Women Reveals Over-Representation of Triple-Negative Breast Cancer

Abstract

These findings underscore the urgent need for research into the etiology and treatment of the aggressive molecular subtypes that disproportionately affect young women in the African diaspora.

Molecular Profiling of Breast Carcinoma in Almadinah, KSA: Immunophenotyping and Clinicopathological Correlation

“…As observed, in our study the percentage of triple negative / basal subtype was represented by 15-20% as in many of the available studies in medical literature (Bhargava et al, 2009;Caldarella et al, 2013;Shomaf et al, 2013;Elesawy et al, 2014;Cherbal et al, 2015). In contrast, a higher percentage between (22.9 -32% was reported in studies from China, Egypt and Nigeria (Huo et al, 2009;El-Hawary et al, 2012;Zheng et al, 2014). Regarding HER-2 subtype, the results from China and Algeria are consistent with our findings (Zhu et al, 2014;Cherbal et al, 2015).…”

Are survivorship care plans responsive to African-American breast cancer survivors?: voices of survivors and advocates

“…BCA treatment is becoming more personalized for patients [42]. Being able to document the nuances of a patient's personalized treatment regimens may be even more critical in AABCS because of the higher rates of triple-negative BCA diseases and late stage diagnoses among African Americans compared to their White counterparts [1,43,44]. The treatment of these cancers may require differing or more aggressive treatments, resulting in increased concerns about treatment side effects and medication regimens.…”

Clinicopathological Features of Indonesian Breast Cancers with Different Molecular Subtypes

“…subtypes in breast cancer study of African-American women and African women, in which the highest frequency was triple negative subtype (Carey et al, 2006;Huo et al, 2009) and a study among North African breast cancer women that luminal B subtype was in the first rank (El-Fatemi et al, 2012). In Pakistan, percentages of non luminal cancers were higher than the luminal.…”