Population-Based Assessment of the Rate of Reactivation Tuberculosis in a Southeastern U.S. Community.

Horsburgh, R; O’Donnell, Max R; Chamblee, Sandra; Moreland, J. D.; Johnson, Johnny; Marsh, Bryan J.; Narita, Michiko; Pedrosa, Maria; Johnson, LS; Reyn, CF von

doi:10.1164/ajrccm-conference.2009.179.1_meetingabstracts.a2200

Cited by 2 publications

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“…Therefore, to determine if rates of reactivation TB have changed since the 1950s and to identify risk factors for reactivation among persons with LTBI, a population-based TST survey and cluster analysis of TB cases was performed in western Palm Beach County, Florida, a geographically circumscribed community, between 1997 and 2001. Some of the results of these studies have been previously reported in the form of an abstract (20).…”

Section: What This Study Adds To the Fieldmentioning

confidence: 96%

Revisiting Rates of Reactivation Tuberculosis

Horsburgh¹,

O’Donnell²,

Chamblee³

et al. 2010

Am J Respir Crit Care Med

126

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Rationale: Reactivation tuberculosis (TB) occurs as a result of reactivation of latent TB infection (LTBI), and was reported to occur in the United States at a rate of 0.10 to 0.16 cases per 100 person-years in the 1950s; it has not been measured since. Objectives: To calculate the rate of reactivation TB in a U.S. community. Methods: A population-based tuberculin skin test survey for LTBI was performed in western Palm Beach County, Florida, from 1998 to 2000 along with a cluster analysis of TB case isolates in the same area from 1997 to 2001. Reactivation (unclustered) TB was presumed to have arisen from the population with LTBI. Measurements and Main Results: The rate of reactivation TB among persons with LTBI without HIV infection was 0.040 cases per 100 person-years (95% confidence interval ½CI, 0.024-0.067) using the n method and 0.058 cases per 100 person-years (95% CI, 0.038-0.089) using the n-1 method. HIV infection was the strongest risk factor for reactivation (rate ratio ½RR, 57; 95% CI, 27-120; P , 0.001). Among persons without HIV infection, reactivation was increased among those older than 50 years (RR, 3.8; 95% CI, 1.3-11) and among those born in the United States (RR, 3.2; 95% CI, 1.1-9.3). Conclusions: Rates of reactivation TB in this area have declined substantially since the 1950s. The greatest part of this decline may be attributed to the disappearance of old, healed TB in the population. If similar declines are seen in other areas of the United States, the cost-effectiveness of screening and treatment of LTBI may be substantially less than previously estimated.

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Section: What This Study Adds To the Fieldmentioning

confidence: 96%

Revisiting Rates of Reactivation Tuberculosis

Horsburgh¹,

O’Donnell²,

Chamblee³

et al. 2010

Am J Respir Crit Care Med

126

View full text Add to dashboard Cite

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To the Issue of the Reactivation of the Tuberculosis Process

Bobokhojaev¹,

SIRODJIDINOVA²,

DJUMAEV³

et al. 2018

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Objective: The article dedicated to debating the degree of certainty of verification of certain types of reactivation of the tuberculosis process, such as relapse, reinfection and superinfection. Analysis of native and foreign publications for the last 10 years on this issue conducted. The authors confirm that even if the outcome of a successful treatment of tuberculosis is deduced based on bacterioscopic and cultural conversion of sputum (outcome "cured"), it is not possible to claim reinfection after eradication or elimination of M. tuberculosis, because it does not exclude its presence in the parenchyma of the lungs, lymph nodes or other organs. If the outcome of successful treatment for various reasons displayed without laboratory confirmation (outcome "completed treatment"), the more so it is impossible to confirm the relapse or reinfection of the disease. Summing up the analysis of the literature, the authors point out the necessity of a differentiated approach in observations in practice and in scientific researches. The use of several costly methods of verification of the form reactivating of the tuberculosis process is not always justified. Ultimately, as recommended WHO, these cases register as new and, depending on the sensitivity to anti-tuberculosis drugs picks up the regimen of repeated chemotherapy. Keywords: Tuberculosis, reactivation, exacerbation, relapse, reinfection, superinfection..

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Population-Based Assessment of the Rate of Reactivation Tuberculosis in a Southeastern U.S. Community.

Cited by 2 publications

References 0 publications

Revisiting Rates of Reactivation Tuberculosis

Revisiting Rates of Reactivation Tuberculosis

To the Issue of the Reactivation of the Tuberculosis Process

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