Pomegranate oil as a valuable pharmaceutical and nutraceutical

Khoddami, Ali; Roberts, Thomas H.

doi:10.1002/lite.201500002

Cited by 20 publications

(13 citation statements)

References 10 publications

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“…Studies have shown that CLNAs suppress tumor cell growth by a mechanism that involves lipid peroxidation [ 16 , 45 , 46 ]. Some researchers have also reported that conjugated fatty acids have antioxidant activity and that this could be a possible explanation for their beneficial health effects [ 27 , 47 , 48 ]. According to Yang et al [ 34 ], although the mechanisms of biological activities related to CLNAs are linked to oxidation, controversial results have been reported.…”

Section: Resultsmentioning

confidence: 99%

“…It is found in high amounts (> 50 %) in pomegranate seed oil (PSO) [ 26 ]. For this reason, PSO has been increasingly investigated as a potent functional food and/or nutraceutical ingredient in foods [ 27 ]. According to Koba et al [ 28 ], because pomegranate abounds in PA its seed oil represents a suitable source for the investigation of the physiological roles of this CLNA isomer.…”

Section: Introductionmentioning

confidence: 99%

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Incorporation and effects of punicic acid on muscle and adipose tissues of rats

et al. 2016

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BackgroundThis study evaluated the effect of pomegranate seed oil (PSO) supplementation, rich in punicic acid (55 %/C18:3-9c,11 t,13c/CLNA), on the lipid profile and on the biochemical and oxidative parameters in the gastrocnemius muscle and adipose tissues of healthy rats. Linseed oil (LO), rich in linolenic acid (52 %/C18:3-9c12c15c/LNA) was used for comparison.MethodsMale Wistar rats (n = 56) were distributed in seven groups: control (water); LNA 1 %, 2 % and 4 % (treated with LO); CLNA 1 %, 2 % and 4 % (treated with PSO), po for 40 days. The percentages were compared to the daily feed intake. Fatty acid profile were performed by gas chromatography, antioxidant enzymes activity by spectrophotometer and the adipocytes were isolated by collagenase tissue digestion. Analysis of variance (ANOVA) was applied to check for differences between the groups (control, LNAs and CLNAs) and principal component analysis (PCA) was used to project the groups in the factor-place (PC1 vs PC2) based on the biochemical responses assessed in the study.ResultsThe fatty acids profile of tissues showed that the LNA percentages were higher in the animals that were fed LO. However, PA was only detected in the adipose tissues. Conjugated linoleic acid (CLA) was present in all the tissues of the animals supplemented with PSO, in a dose dependent manner, and 9c11t-CLA was the predominant isomer. Nevertheless there were no changes in the total weight gain of the animals, the weights of the tissues, and the oxidative stress parameters in the muscle. In addition, there was an increase in the size of the epididymal fat cells in the groups treated with PSO. Principal component analysis (PCA) showed that the CLNAs groups were arranged separately with a cumulative variance of 68.47 %.ConclusionsThe results show that PSO can be used as a source of CLAs but that it does not cause changes in body modulation and does not interfere in the antioxidant activity of healthy rats.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Incorporation and effects of punicic acid on muscle and adipose tissues of rats

et al. 2016

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“…This fatty acid has been indicated to have positive health effects, such as cholesterol lowering, antidiabetic, anti‐inflammatory, and anticarcinogenic properties . Moreover, pomegranate seed oil (PSO) is rich in other important functional compounds, such as polyphenols, including gallic acid and ellagic acid, phytosterols (β‐sitosterol, campesterol, and stigmasterol) and tocopherols, mainly γ‐tocopherol . Due to its peculiar composition, PSO is today widely used in cosmetic and pharmaceutical products and there are still few applications of this oil as functional ingredient in foods .…”

Section: Introductionmentioning

confidence: 99%

Pomegranate seed oil organogels structured by propolis wax, beeswax, and their mixture

Fayaz

Goli

Kadivar

et al. 2017

Euro J Lipid Sci & Tech

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The capability of propolis wax, beeswax, and their mixture to gel pomegranate seed oil (PSO) was studied. Samples were prepared increasing the concentration of waxes in pomegranate seed oil from 5 to 15% w/w. After propolis wax, beeswax, and PSO chemical characterization, thermal, and structural properties of wax-based organogels were studied. Both propolis wax and beeswax formed organogel thanks to the presence of crystal networks made of needle-like β′-form crystals. Based on FTIR spectroscopy, mainly van der Waals interactions were formed in the systems. Propolis wax organogels displayed lower firmness and G′ and G″ modulus in comparison to the corresponding beeswax samples. This was due to the presence of larger crystals with a less organized network. The observed behaviors were attributed to differences in chemical composition between these two types of waxes. The combined use of propolis wax and beeswax led to organogels with behavior in between the organogels with single waxes, probably as a consequence of the formation of mixed crystals. Practical applications: Pomegranate seed oil (PSO) with considerable amounts of polyunsaturated fatty acids can be convert into structured systems by oil gelation as a novel strategy to delivery it in a system that allows its incorporation in the food matrix. The obtain data acquired in this research highlight that propolis and bees waxes and their mixture can be considered as good gelators of PSO. The final structure of the organogel can be tailored by selecting the organogelator and its concentration in the use of fat based alternative in food products need β′-form crystals such as spreads and margarines. The aim of the present research is to develop pomegranate seed oil (PSO) organogels by using beeswax, propolis wax, and their mixture. Organogels are characterized by using different techniques, including polarized light microscopy (PLM), Fourier transform infrared (FTIR) spectroscopy, DSC analysis, synchrotron X-ray diffraction, rheology, and mechanical properties. In accordance with findings, both propolis and bees waxes can be considered as good gelators of PSO. Depending on intended food application, the final structure of the organogel can be tailored by selecting the organogelator and its concentration

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“…The constituents of PSO could mainly be grouped into lipids, tocopherols, and sterols. [38,43,44] However, these components vary from one study to another and Amri et al [39] attributed this fluctuation to genetic variability, extraction process, and maturation stage of pomegranate fruit. The fatty acid compositions estimated in PSO from different countries varied substantially in terms of quantity and types (Table 1).…”

Section: Chemical Compositionsmentioning

confidence: 99%

Formulation of Pomegranate Seed Oil: A Promising Approach of Improving Stability and Health‐Promoting Properties

Adu‐Frimpong

Omari‐Siaw

Mukhtar

et al. 2018

Euro J Lipid Sci & Tech

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Emerging evidence has suggested that nutraceutical ingredients like pomegranate seed oil (PSO) possesses health‐promoting effects in cell and animal models. However, these health benefits (anticancer, antioxidant, anti‐inflammatory, anti‐diabetic, and so on) are limited by low physicochemical stability, slow intestinal absorption, and rapid metabolism of PSO. In order to overcome these drawbacks, some carriers viz., nanoemulsion, encapsulation, and nanoparticles are developed recently. This paper assesses the chemical compositions and physicochemical properties of PSO, as well as biological activities and possible mechanisms. It also discusses the formulation of PSO for improved stability and health‐promoting activities. Practical Applications: This review highlights the prospects of PSO formulation. The relevance of this study is that the stability and biological properties of PSO could be enhanced through nanocarriers. A formulated PSO has a potential use in nutraceutical, functional foods, pharmaceutical and cosmetic industries. PSO, a source of various nutrients and antioxidants with immense benefits to human health is incorporated into nanocarriers such as microencapsulation, nanoemulsion and nanoparticle. This improved the health‐promoting benefits of the oil.

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Pomegranate oil as a valuable pharmaceutical and nutraceutical

Cited by 20 publications

References 10 publications

Incorporation and effects of punicic acid on muscle and adipose tissues of rats

Incorporation and effects of punicic acid on muscle and adipose tissues of rats

Pomegranate seed oil organogels structured by propolis wax, beeswax, and their mixture

Formulation of Pomegranate Seed Oil: A Promising Approach of Improving Stability and Health‐Promoting Properties

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