Pomegranate-Like CuO₂@SiO₂ Nanospheres as H₂O₂ Self-Supplying and Robust Oxygen Generators for Enhanced Antibacterial Activity

Abstract

Reactive oxygen species (ROS)-induced nanosystems represent one of the most essential, efficient, and encouraging nanobactericides for eliminating bacterial infection concerning the increasing resistance threats of existing antibiotics. Among them, Fenton-type metal peroxide nanoparticles are exciting nanomaterials with intriguing physiochemical properties, yet the study of this antimicrobial agent is still in its infancy. Herein, a robust pH-responsive Fenton nanosystem is constructed by the assembly of copper peroxide nanodots in pomegranate-like mesoporous silica nanoshells (CuO2@SiO2) that are capable of self-supplying H2O2 and sustainably generating O2. The enhanced antimicrobial performance is attributed to the pH responsiveness and excellent Fenton catalytic activity through either the Cu2+-catalyzed conversion of H2O2 to detrimental ROS under acid treatment or in situ O2 evolution in neutral media. Moreover, in vitro and in vivo investigations demonstrate that this nanocomposite can exhibit boosted antimicrobial capabilities and can significantly accelerate skin wound closure, while retaining outstanding cytocompatibility and hemocompatibility. Given its excellent physicochemical and antimicrobial properties, the broad application of this nanocomposite in bacteria-associated wound management is anticipated.

Injectable self-healing hydrogel fabricated from antibacterial carbon dots and ɛ-polylysine for promoting bacteria-infected wound healing

“…Multitudinous nanoscale germicides, such as noble metal (eg. Au, Ag, Pd, Ru, Pt) [4][5][6][7][8][9][10][11][12] nanoparticles (NPs), metallic oxide [13][14][15][16][17] (eg. ZnO, TiO 2 and CuO) NPs, and carbonaceous nanomaterials [18][19][20] have been exploited as antimicrobial alternatives, which exhibit high potency with broad spectrum antibacterial activity.…”

Copper peroxide coated upconversion nanoparticle modified with glucose oxidase for H2O2self-supplying starvation-enhanced chemodynamic therapyin vitro

“…Previous research has found that copper peroxide (CuO 2 ) nanodots could specifically be triggered by the acidic environment of tumors and produce a great deal of Cu 2+ and H 2 O 2 , and at the same time, Cu 2+ can directly reduce GSH to promote CDT. [19][20][21] Glucose oxidase (GOx) can efficiently catalyze glucose into gluconic acid and H 2 O 2 by utilizing O 2 as an electron acceptor, thus cutting off the energy supply of cancer cells and inhibiting tumor growth. 22 The process is known as GOx-based starvation therapy and has attracted increasing interest in cancer treatment due to its inherent biosecurity.…”

“…45 The generated H 2 O 2 was further catalyzed by Cu + to generate • OH with high reactivity through a Fenton-like reaction, which in turn enhanced the generation of ROS in CDT. 19,21,46 Meanwhile, Cu 2+ was reduced to Cu + by GSH for CDT. 21 The in vitro experiments have confirmed the advantages of such a synergistic therapeutic effect through the integration of starvation therapy and CDT, which is expected to facilitate the development of multi-mode therapy in tumor treatment.…”

Nickel Phthalocyanines as Potential Aggregation‐Induced Antibacterial Agents: Fenton‐Like Pathways Driven by Near‐Infrared Light

“…[2] To date, over 700,000 deaths annually worldwide is caused by antibiotic resistant infections. [3] In addition, bacterial colonies are also an urgent problem of environmental pollution. Bacteria have developed an inherent ability to evade much of the activity of traditional antibiotics.…”

“…Multidrug‐resistant (MDR) bacteria are a global crisis that increases morbidity and mortality among those infected and negatively impacts clinical outcomes in a wide range of populations, including intensive care units or those receiving surgery, transplant or cancer treatment [2] . To date, over 700,000 deaths annually worldwide is caused by antibiotic resistant infections [3] . In addition, bacterial colonies are also an urgent problem of environmental pollution.…”