Copper peroxide coated upconversion nanoparticle modified with glucose oxidase for H2O2self-supplying starvation-enhanced chemodynamic therapyin vitro

Hong, Yale; Tao, Qinfeng; Liu, Yuan-Yuan; Wang, Zhuo; Wang, Haifang; Sun, Lining

doi:10.1039/d2dt00163b

Cited by 9 publications

(8 citation statements)

References 48 publications

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“…The color variation of KMnO 4 (50 μg ml −1 ) in acidic media can be used for qualitative analysis of the generation of peroxy groups (•OH). [34] Circular membrane specimens (Φ = 10 mm) were infiltrated with 1 mL acidic KMnO 4 for 30 min, and the absorbance at 520 nm was measured by a UV-vis spectrophotometer (AOE, UV-1000).…”

Section: Colorimetric Assessment For Peroxy Groupsmentioning

confidence: 99%

“…[30,31] Moreover, Cu 2+ has been reported to simulate hypoxia in wound sites, contributing to the stabilization of hypoxia-inducible factor (HIF-1𝛼) and the expression of downstream-targeted genes, including vascular endothelial growth factor (VEGF), which enhances angiogenesis and promotes wound healing. [32] While n-CuO 2 has expressed some promising applications in CDT for cancer treatment, [33][34][35] its applications for chronic wound healing are still in their infancy. [36] To date, very few studies have reported the potential of PCL-based EUFs for enhancing angiogenesis within diabetic wounds.…”

Section: Introductionmentioning

confidence: 99%

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Guiding the Path to Healing: CuO₂‐Laden Nanocomposite Membrane for Diabetic Wound Treatment

Qi,

Huang,

Sun

et al. 2023

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Diabetic chronic wounds pose significant clinical challenges due to their characteristic features of impaired extracellular matrix (ECM) function, diminished angiogenesis, chronic inflammation, and increased susceptibility to infection. To tackle these challenges and provide a comprehensive therapeutic approach for diabetic wounds, the first coaxial electrospun nanocomposite membrane is developed that incorporates multifunctional copper peroxide nanoparticles (n‐CuO2). The membrane's nanofiber possesses a unique “core/sheath” structure consisting of n‐CuO2+PVP (Polyvinylpyrrolidone)/PCL (Polycaprolactone) composite sheath and a PCL core. When exposed to the wound's moist environment, PVP within the sheath gradually disintegrates, releasing the embedded n‐CuO2. Under a weakly acidic microenvironment (typically diabetic and infected wounds), n‐CuO2 decomposes to release H2O2 and Cu2+ ions and subsequently produce ·OH through chemodynamic reactions. This enables the anti‐bacterial activity mediated by reactive oxygen species (ROS), suppressing the inflammation while enhancing angiogenesis. At the same time, the dissolution of PVP unveils unique nano‐grooved surface patterns on the nanofibers, providing desirable cell‐guiding function required for accelerated skin regeneration. Through meticulous material selection and design, this study pioneers the development of functional nanocomposites for multi‐modal wound therapy, which holds great promise in guiding the path to healing for diabetic wounds.

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Section: Colorimetric Assessment For Peroxy Groupsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Guiding the Path to Healing: CuO₂‐Laden Nanocomposite Membrane for Diabetic Wound Treatment

Qi,

Huang,

Sun

et al. 2023

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“…Two biological processes have been employed recently to produce H 2 O 2 in tumors. First, glucose oxidase (GO x ) is used to accelerate the reaction of water, oxygen, and glucose to form gluconic acid and H 2 O 2 [151]. Te alternative process uses superoxide dismutase (SOD) to catalyse the production of H 2 O 2 from superoxide anion radicals [150].…”

Section: Improved Chemodynamic Terapy Chemodynamic Therapy (Cdt) Is A...mentioning

confidence: 99%

Targeting Tumor Microenvironment by Metal Peroxide Nanoparticles in Cancer Therapy

Mbugua

2022

Bioinorganic Chemistry and Applications

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Solid tumors have a unique tumor microenvironment (TME), which includes hypoxia, low acidity, and high hydrogen peroxide and glutathione (GSH) levels, among others. These unique factors, which offer favourable microenvironments and nourishment for tumor development and spread, also serve as a gateway for specific and successful cancer therapies. A good example is metal peroxide structures which have been synthesized and utilized to enhance oxygen supply and they have shown great promise in the alleviation of hypoxia. In a hypoxic environment, certain oxygen-dependent treatments such as photodynamic therapy and radiotherapy fail to respond and therefore modulating the hypoxic tumor microenvironment has been found to enhance the antitumor impact of certain drugs. Under acidic environments, the hydrogen peroxide produced by the reaction of metal peroxides with water not only induces oxidative stress but also produces additional oxygen. This is achieved since hydrogen peroxide acts as a reactive substrate for molecules such as catalyse enzymes, alleviating tumor hypoxia observed in the tumor microenvironment. Metal ions released in the process can also offer distinct bioactivity in their own right. Metal peroxides used in anticancer therapy are a rapidly evolving field, and there is good evidence that they are a good option for regulating the tumor microenvironment in cancer therapy. In this regard, the synthesis and mechanisms behind the successful application of metal peroxides to specifically target the tumor microenvironment are highlighted in this review. Various characteristics of TME such as angiogenesis, inflammation, hypoxia, acidity levels, and metal ion homeostasis are addressed in this regard, together with certain forms of synergistic combination treatments.

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“…15 GO x can catalyze glucose to produce gluconic acid and H 2 O 2 . 17 Thus, in the presence of glucose, the bimetallic Al/Fe-based NMOF loaded with GO x will decrease the pH value of the bacterial infection microenvironment and avoid the addition of exogenous H 2 O 2 . 18…”

Section: Introductionmentioning

confidence: 99%

Effective antibacterial action of a 2D bimetallic Al/Fe-TCPP NMOF loaded with glucose oxidase by a cascade catalytic reaction and depleting glutathione simultaneously

Liao,

Yao,

Duan

et al. 2024

New J. Chem.

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Copper peroxide coated upconversion nanoparticle modified with glucose oxidase for H₂O₂self-supplying starvation-enhanced chemodynamic therapyin vitro

Abstract: Chemodynamic therapy (CDT) can convert endogenous hydrogen peroxide (H2O2) to highly reactive hydroxyl radical (•OH) through Fenton or Fenton-like reaction to kill tumor cells, which is a promising anticancer strategy....

Cited by 9 publications

References 48 publications

Guiding the Path to Healing: CuO₂‐Laden Nanocomposite Membrane for Diabetic Wound Treatment

Guiding the Path to Healing: CuO₂‐Laden Nanocomposite Membrane for Diabetic Wound Treatment

Targeting Tumor Microenvironment by Metal Peroxide Nanoparticles in Cancer Therapy

Effective antibacterial action of a 2D bimetallic Al/Fe-TCPP NMOF loaded with glucose oxidase by a cascade catalytic reaction and depleting glutathione simultaneously

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Copper peroxide coated upconversion nanoparticle modified with glucose oxidase for H2O2self-supplying starvation-enhanced chemodynamic therapyin vitro

Abstract: Chemodynamic therapy (CDT) can convert endogenous hydrogen peroxide (H2O2) to highly reactive hydroxyl radical (•OH) through Fenton or Fenton-like reaction to kill tumor cells, which is a promising anticancer strategy....

Cited by 9 publications

References 48 publications

Guiding the Path to Healing: CuO2‐Laden Nanocomposite Membrane for Diabetic Wound Treatment

Guiding the Path to Healing: CuO2‐Laden Nanocomposite Membrane for Diabetic Wound Treatment

Targeting Tumor Microenvironment by Metal Peroxide Nanoparticles in Cancer Therapy

Effective antibacterial action of a 2D bimetallic Al/Fe-TCPP NMOF loaded with glucose oxidase by a cascade catalytic reaction and depleting glutathione simultaneously

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Product

Resources

About

Copper peroxide coated upconversion nanoparticle modified with glucose oxidase for H₂O₂self-supplying starvation-enhanced chemodynamic therapyin vitro

Guiding the Path to Healing: CuO₂‐Laden Nanocomposite Membrane for Diabetic Wound Treatment

Guiding the Path to Healing: CuO₂‐Laden Nanocomposite Membrane for Diabetic Wound Treatment