Polyzwitterion-crosslinked hybrid tissue with antithrombogenicity, endothelialization, anticalcification properties

Glycidyl methacrylate-crosslinked fish swim bladder as a novel cardiovascular biomaterial with improved antithrombotic and anticalcification properties

“…Most of the non-glutaraldehydecrosslinking system showed an anti-calcification potential due to the absence of aldehyde group residue. 30 The calcification of GMA-SBs was evaluated by the subcutaneous implantation. After 1 and 2 months of implantation, GMA-SBs underwent mild calcification and exhibited better anticalcification properties than GLUT-SBs (Figure 11(b)).…”

Visible light–induced cross‐linking of porcine pericardium for the improvement of endothelialization, anti‐tearing, and anticalcification properties

“…The cytotoxicity of the PP samples was assessed according to the ISO 10993‐5 standard. Briefly, the small pieces of CF3‐PP, Glut‐PP, and D‐PP (3 cm × 3 cm) were washed ultrasonically with DI water and sterilized with peroxyacetic acid solution (0.25% [vol/vol], pH = 7.0) and glutaraldehyde solution (1% [vol/vol]), according to our previous study 23 . After sterilization, the materials were washed with sterile PBS solution thoroughly to remove the sterilizing agent.…”

“…The small pieces of CF3‐PP, Glut‐PP, and D‐PP (10 mm diameter) were washed with DI water and sterilized as described previously in our study 23 . The autoclaved stainless‐steel ring was pressed on each sample to secure the bottom of the 48‐well plate.…”

Preparation and characterisation of zwitterionic sulfobetaine containing siloxane-based biostable polyurethanes

“…10,18 Although the siloxane-based biostable PCUs possess good long-term biostability and biocompatibility, their anticoagulant and antithrombotic characters are far from perfect when they are used as blood-contacting biomaterials. Up to now many attempts have been made to reduce coagulation and thrombosis of medical PUs, for example, hyperhydrophobicity, 19,20 hydrophilicity, 21 heparinisation, [22][23][24] zwitterionic modification 25,26 and biomimetic design strategies. [27][28][29] It should be noted that most of these anticoagulant and antithrombotic strategies improve the biocompatibility of medical PUs as bloodcontacting biomaterials through surface modification.…”

“…Among them, the sulfobetaine amphoteric monomer has received increasingly growing attention because of its good chemical and thermal stability and strong hydration ability. 25,26,[31][32][33] Nowadays various zwitterionic polymers are broadly used in the fabrication or coating of long-term bloodcontacting medical devices, such as small diameter vascular grafts, arteriovenous access, artificial lungs, and microfluidic devices for their good hydration properties and strong antifouling ability. 26,34,35 Meanwhile, the mechanism of zwitterionic polymers, how to reduce and impede protein adsorption and platelet deposition, has also been illuminated recently.…”