Prosthetic heart valve replacement is an effective therapy for patients with valvular heart disease. New-type polymer materials provide potential choices of material for preparing prosthetic heart valves. In this study,...
Heart
valve replacement is an effective therapy for patients with
moderate to severe valvular stenosis or regurgitation. Most bioprosthetic
heart valves applied clinically are based on cross-linking with glutaraldehyde
(GLUT), but they have some drawbacks like high cytotoxicity, severe
calcification, and poor hemocompatibility. In this study, we focused
on enhancing the properties of bioprosthetic heart valves by cross-linking
with 3,4-dihydroxybenzaldehyde (DHBA). The experiment results revealed
that compared with GLUT cross-linked porcine pericardium (PP), the
relative amount of platelets absorbed on the surface of DHBA cross-linked
PP decreased from 0.294 ± 0.034 to 0.176 ± 0.028, and the
activated partial thromboplastin time (APTT) increased from 9.9 ±
0.1 to 15.2 ± 0.1 s, indicating improved hemocompatibility. Moreover,
anticalcification performance and cytocompatibility were greatly enhanced
by DHBA cross-linking. In conclusion, the properties of bioprosthetic
valves could be effectively improved by processing valves with a DHBA-based
cross-linking method.
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