Polyurethane foam/nano hydroxyapatite composite as a suitable scaffold for bone tissue regeneration

Drug Leaching Properties of Vancomycin Loaded Mesoporous Hydroxyapatite as Bone Substitutes

“…Therefore, using a UV-visible spectrophotometer, a known concentration of (2-10 mg/mL) vancomycin was scanned. [10] for all samples, except for a small additional peak present due to β-TCP in HAP and HAP-LA respectively, which could have been introduced during the process of sintering. Table 1 shows the size of crystallite and the percentage of HAP, HAP-LA and HAP-SA crystallinity along with stoichiometry.…”

“…A simple impregnation technique with optimized conditions ensured a high antibiotic loading (up to 0.476 + 0.0135 mg/mL), with a complete in vitro release obtained within 50 h.Processes 2019, 7, 826 2 of 12 considered to be ideal materials for coating on metallic biomaterials as it possesses almost the closest similarity in chemical composition and excellent biocompatibility with natural bone tissue. The Hydroxyapatite (HAP) is non-toxic and biocompatible [6-9] exhibiting excellent osteointegration and osteoconductivity characteristics [10,11]. In this contest, the bioceramic hydroxyapatite (HAP) with similar chemical constituents of bones and hard tissues is often used as implants in orthopedic, dental or maxillofacial use can approve bone development and osteointegration [12].…”

Biological properties of calcium phosphate biomaterials for bone repair: a review

“…Generally, CaP coating is incorporated with polymer via coating on the polymer surface or mixing these two ingredients and then shaping using desired scaffolds. Coated composites are usually prepared by electrochemically assisted co-deposition 154 or two-step biomimetic methods; 155,156 the mixed composites are fabricated via the 3D printing technique, 157 extrusion or direct injection into the bone defect site. Interestingly, the CaP-coated polymer nanober was recently fabricated by Junginger et al 158 via the mineralization process, and it is thought to add value to the synthesis of advanced hybrid materials for bone repair.…”

Polymers and Scaffolds with Improved Blood Compatibility and Enhanced Cellular Response with Focus on Polyurethane Foams Functionalized with Amino-Amide Groups

“…In the recent years, the Authors' research group acquired the know-how for the preparation of biocompatible polyurethane foams prepared by a one-step expansion procedure using water as expanding agent [22][23][24]. Among other applications, the developed 3D PU scaffolds were investigated for bone tissue engineering [25] and as in vitro model for breast cancer bone metastasis [26]. However, by an appropriate selection of the regents and relative stoichiometry, PU scaffold could be designed for regeneration of soft tissues, such as skin and adipose tissue.…”

“…PU foams were obtained by a previously optimized one-step gas foaming reaction [25], by reacting an ad hoc prepared poly-ether-polyol mixture and additives with a polyisocyanate (a modified diphenyl-methane-4,4'-diisocyanate, MDI), using water as expanding agent and Fe-Acetylacetonate (FeAA, Iron(III) acetylacetonate ≥99.9%, Sigma-Aldrich) as reaction catalyst. The composition of the control foams and PIME-containing ones is shown in Table 1.…”