Polysaccharides isolated from Phellinus gilvus inhibit melanoma growth in mice

Bae, Ji‐Hoon; Jang, Kwang-Ho; Yim, Hyunee; Jin, Hee-Kyung

doi:10.1016/j.canlet.2004.08.002

Cited by 52 publications

(28 citation statements)

References 31 publications

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“…By upregulating cell cycle regulatory p21WAF/Cip1 and proapoptotic protein Bax levels, PSK could arrest pancreatic cancer cell cycle and induce apoptosis. Similar study also showed that Phellinus gilvus could exhibit antitumor effects by significantly increasing the melanoma apoptosis rate (Bae et al 2005) …”

Section: Inducing Apoptosissupporting

confidence: 52%

Polysaccharides from Medicinal Mushrooms and Their Antitumor Activities

Chen¹,

Li²

2015

Polysaccharides

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Section: Inducing Apoptosissupporting

confidence: 52%

Polysaccharides from Medicinal Mushrooms and Their Antitumor Activities

Chen¹,

Li²

2015

Polysaccharides

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“…In most cases, intraperitoneal administration is more rapid and effective than oral (Bae et al, 2005). Intraperitoneal administration of the endo-polysaccharide significantly prolonged the survival rate of B16F10-implanted mice, approximately 67% of the initial number of mice survived with no tumor incidence after 60 days of feeding (Kim et al, 2006).…”

Section: Indirect Anticancer Effects Via Immunostimulatingmentioning

confidence: 99%

Progress on Understanding the Anticancer Mechanisms of Medicinal Mushroom: Inonotus Obliquus

Song¹,

Liu²,

Kong³

et al. 2013

Asian Pacific Journal of Cancer Prevention

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“…Recently, polysaccharides isolated from Phellinus mushrooms have received special attention due to their potent pharmacological activities, including anti-tumor [2,4,5,10], immunostimulating [15], and anti-inflammatory properties [13,14]. Among these Phellinus mushrooms, PG used in this study has advantages over the other Phellinus mushrooms in that it has a very short growth period (3 months) compared to other Phellinus mushrooms (2-3 years) making it cheaper to produce.…”

mentioning

confidence: 99%

Promotion of Dermal Wound Healing by Polysaccharides Isolated from Phellinus gilvus in rats

Bae

Jang

Park

et al. 2005

The Journal of Veterinary Medical Science

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ABSTRACT. The effects of topical administration of polysaccharides isolated from fungus, Phellinus gilvus (PG) on the healing of rat dermal wounds were assessed. In 10 Sprague-Dawley (SD) rats, six 6 mm diameter defects were made with a punch biopsy appliance. After 24 hr, test substances were applied to the defects twice a day: 0.025, 0.25, and 2.5% polysaccharides from PG (PG0.025, 0.25, and 2.5 groups), Madecassol ® ointment (MC group), aqueous gel (AG group) and no treatment (control group). Six days postoperatively, the contraction and reepithelialization of the wound surface were assessed. Wound diameter was significantly reduced in all PG groups (P<0.05). Complete epithelialization and macrophages were noted in the PG0.25 group, as compared to the control group. We conclude that polysaccharides isolated from PG have significant dermal wound healing effects, and this investigation suggests the potential clinical application of PG as a wound healing agent.

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Polysaccharides isolated from Phellinus gilvus inhibit melanoma growth in mice

Cited by 52 publications

References 31 publications

Polysaccharides from Medicinal Mushrooms and Their Antitumor Activities

Polysaccharides from Medicinal Mushrooms and Their Antitumor Activities

Progress on Understanding the Anticancer Mechanisms of Medicinal Mushroom: Inonotus Obliquus

Promotion of Dermal Wound Healing by Polysaccharides Isolated from Phellinus gilvus in rats

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