Polysaccharides in Oral Drug Delivery — Recent Applications and Future Perspectives

Klein, Sandra

doi:10.1021/bk-2009-1017.ch001

Cited by 16 publications

(10 citation statements)

References 29 publications

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“…Natural polymers have a wide range of applications in the medical field, e.g., drug delivery systems because they break down to form physiological metabolites. 9 Polysaccharides are nothing but carbohydrates which are ubiquitous biopolymers built up from monosaccharides, and 99% are located in plants. 10 Polysaccharides, in particular, have some excellent properties which make them the polymer group with…”

Section: Discussionmentioning

confidence: 99%

Efficacy of Sodium Carboxymethyl in Mandibular Extraction Sockets

Umashankar¹,

Saha²,

Srinath³

et al. 2018

IJPCDR

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Aim: The present study was carried out to assess the wound healing, bone formation, and preservation after placing sodium carboxymethyl starch in mandibular extraction sockets. Materials and methods: A prospective study with a sample size of 60 where 30 patients received sodium carboxymethyl on one of the mandibular extraction sockets as the test group and contralateral side was used as the control group. Student's paired t-test and McNemar test were used for statistical tabulation. Results: On assessing bone density, the test group showed more mean values of bone density 2.33 HU, p-value of 0.14 in 3rd month, and 2.37 HU, p-value of 0.04 in 6th month postoperative respectively. Conclusion: Placement of sodium carboxymethyl starch significantly increases the bone density during regeneration of extraction sockets which might promise us good quality of bone formation. However, further research in the material and a longer follow-up period are desirable for a definitive conclusion.

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Section: Discussionmentioning

confidence: 99%

Efficacy of Sodium Carboxymethyl in Mandibular Extraction Sockets

Umashankar¹,

Saha²,

Srinath³

et al. 2018

IJPCDR

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“…Moreover, they can attach to body tissues and mucus layers and sustain the release of encapsulated active ingredients [13]. The aforementioned properties have attracted attention towards the usage of polysaccharides in major industries including food, agronomy, cosmetics, biochemical engineering and pharmaceutical manufacturing [30,31].…”

Section: Natural Polysaccharidesmentioning

confidence: 99%

“…It is the only saccharide possessing a high density positive net charge, which allows it to interact with a wide range of anionic polymers and biological molecules [32]. In addition, CS shows high mucoadhesion in the GIT which increases the residence time and enhances the permeation of active molecules [30]. Hence, CS is used commonly in the food industry, for pharmaceutical drug delivery and tissue engineering [37,38].…”

Section: Chitosan (Cs)mentioning

confidence: 99%

An Overview of Chitosan-Xanthan Gum Matrices as Controlled Release Drug Carriers

Dadou¹,

Antonijević²,

Chowdhry³

et al. 2018

Chitin-Chitosan - Myriad Functionalities in Science and Technology

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Naturally occurring polysaccharides and/or their chemically modified derivatives have been widely investigated in relation to their use as components of controlled release systems for drug delivery. The aforementioned is due, in part, to their distinct properties such as abundant availability and biocompatibility as well as environmental and economic advantages. Chitosan (CS) and xanthan gum (XG) based matrices have received growing scientific/pharmaceutical interest as oral controlled release drug carriers. Herein, recent advances spanning the last two decades in CS-XG based drug delivery systems are reviewed with the emphasis being on oral tablet formulations, due to their versatility as pharmaceutical dosage forms. The mechanism of interaction between CS and XG, by means of computational and experimental approaches, is scrutinized. Results obtained from the literature establish the possibility of fabricating a controlled release drug delivery system based on CS and XG matrices. This can be achieved by monitoring and manipulating the physiochemical properties of the two polymers as well as the experimental variables affecting their drug retardation efficiency, without the need to employ special equipment or sophisticated experimental techniques/methodologies.

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“…Polysaccharides with quaternary ammonium groups (derivatives of cellulose, guar gum, starch, chitosan, hyaluronan, dextran, pullulan) have some important properties as for example: hydrophilicity, biodegradability, biocompatibility, and bacteriostatic properties, very useful for bio-applications (Klein, 2010;Rinaudo, 2008). These cationic polysaccharides can be obtained by the reaction of the native polymers with various reagents with ammonium groups.…”

Section: Introductionmentioning

confidence: 99%