Polysaccharides extracted from Phellinus linteus ameliorate high-fat high-fructose diet induced insulin resistance in mice

Han, Feng; Zhang, Shijie; Wan, Jennifer Man-Fan; Gui, Lifeng; Ruan, Mengcheng; Li, Na; Zhang, Hongyu; Liu, Zhiguo

doi:10.1016/j.carbpol.2018.07.086

Cited by 61 publications

(33 citation statements)

References 56 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The hypoglycemic effect of P. linteus extracts has been documented in several studies 24,[35][36][37] ; however, the interrelationships among intestinal microbial regulation, chronic inflammation, and liver insulin resistance in widely used diabetic rat models remain to be clarified in detail. In the present study, PLPE treatment increased abundance of SCFA-producing bacteria in a type 2 diabetic rat model.…”

Section: Discussionmentioning

confidence: 99%

Phellinus linteus polysaccharide extract improves insulin resistance by regulating gut microbiota composition

Liu

Wang

et al. 2019

The FASEB Journal

View full text Add to dashboard Cite

The hypoglycemic effect of Phellinus linteus polysaccharide extract (PLPE) has been documented in several previous studies, but the functional interactions among PLPE, gut microbiota, and the hypoglycemic effect remain unclear. We examined the regulatory effect of PLPE on gut microbiota, and the molecular mechanism underlying improvement of insulin resistance, using a type 2 diabetic rat model. Here, 24 male Sprague‐Dawley rats were randomly divided into four groups that were subjected to intervention of saline (normal and model control group), metformin (120 mg/kg.bw), and PLPE (600 mg/kg.bw) by oral administration. After 8 weeks of treatment, PLPE increased levels of short‐chain fatty acids (SCFAs) by enhancing abundance of SCFA‐producing bacteria. SCFAs maintained intestinal barrier function and reduced lipopolysaccharides content in blood, thereby helping to reduce systemic inflammation and reverse insulin resistance. Our findings suggest that PLPE (in which polysaccharides are the major component) has potential application as a prebiotic for regulating gut microbiota composition in diabetic patients.

show abstract

Section: Discussionmentioning

confidence: 99%

Phellinus linteus polysaccharide extract improves insulin resistance by regulating gut microbiota composition

Liu

Wang

et al. 2019

The FASEB Journal

View full text Add to dashboard Cite

show abstract

“…They also helped slow or reverse metabolic syndrome by correcting intestinal microbial disorders associated with HFD, promoting integrity of intestinal epithelia, and reducing chronic inflammation. P. linteus polysaccharides ameliorated HFD-induced and high-fructose-diet-induced insulin resistance in mice by regulating intestinal flora involved in vitamin B12 synthesis [31]. Studies are underway to elucidate the detailed mechanisms whereby P. linteus polysaccharides help control diabetes through their regulatory effects on intestinal microbes.…”

Section: Discussionmentioning

confidence: 99%

“…Kim, H.’s group found that mycelial polysaccharides of P. linteus under submerged fermentation inhibited expression of inflammatory cytokines IFN-γ and TNF-α, and development of diabetes in non-obese diabetic (NOD) mice [29]. Polysaccharides from mycelia and hot water extracts of fruiting bodies of P. linteus were useful for diabetes treatment by reducing oxidative damage of islet cells, promoting insulin secretion, and enhancing insulin resistance [17,30,31]. The small molecule hispidin and phenolic compounds purified from P. linteus were also useful for diabetes treatment [32,33,34].…”

Section: Introductionmentioning

confidence: 99%

Hypoglycemic and Hypolipidemic Effects of Phellinus Linteus Mycelial Extract from Solid-State Culture in A Rat Model of Type 2 Diabetes

Liu

Wang

et al. 2019

Nutrients

View full text Add to dashboard Cite

Hypoglycemic and hypolipidemic effects of P. linteus have been observed in numerous studies, but the underlying molecular mechanisms are unclear. In this study, we prepared P. linteus extract (PLE) from mycelia of solid-state culture, and evaluated its hypoglycemic and hypolipidemic effects in rat models of high-fat diet (HFD)-induced and low-dose streptozotocin (STZ)-induced type 2 diabetes. PLE treatment effectively reduced blood glucose levels, and improved insulin resistance and lipid and lipoprotein profiles. The hypoglycemic effect of PLE was based on inhibition of key hepatic gluconeogenesis enzymes (FBPase, G6Pase) expression and hepatic glycogen degradation, and consequent reduction of hepatic glucose production. PLE also: (i) enhanced expression of CPT1A and ACOX1 (key proteins involved in fatty acid β-oxidation) and low-density lipoprotein receptor (LDLR) in liver, thus promoting clearance of triglycerides and LDL-C; (ii) inhibited expression of 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR) in liver, thus reducing cholesterol production; (iii) displayed strong hepatoprotective and renal protective effects. Our findings indicate that PLE has strong potential functional food application in adjuvant treatment of type 2 diabetes with dyslipidemia.

show abstract

“…This role has been attributed to the biological activity of its various components, including polysaccharides, triterpenoids, polyphenols, and pyrans. Based on modern pharmacological studies, P. linteus is reported to have multifaceted biological activities, including anti-inflammatory [6,7,8,9,10,11,12,13,14], immunomodulatory [15,16,17,18,19], antioxidative [20,21,22,23,24,25,26], antimicrobial, and antiviral [27,28,29,30,31,32,33], as well as anticancer [34,35,36,37,38,39,40,41,42,43,44,45,46,47,48,49,50,51,52,53,54,55,56,57], antidiabetic [58,59,60,61,62,63,64,65,66,67], hepatoprotective […”

Section: Introductionmentioning

confidence: 99%

A Review: The Bioactivities and Pharmacological Applications of Phellinus linteus

et al. 2019

View full text Add to dashboard Cite

Phellinus linteus is a popular medicinal mushroom that is widely used in China, Korea, Japan, and other Asian countries. P. linteus comprises various bioactive components, such as polysaccharides, triterpenoids, phenylpropanoids, and furans, and has proven to be an effective therapeutic agent in traditional Chinese medicine for the treatment and the prevention of various diseases. A number of studies have reported that P. linteus possesses many biological activities useful for pharmacological applications, including anticancer, anti-inflammatory, immunomodulatory, antioxidative, and antifungal activities, as well as antidiabetic, hepatoprotective, and neuroprotective effects. This review article briefly presents the recent progress made in understanding the bioactive components, biological activities, pharmacological applications, safety, and prospects of P. linteus, and provides helpful references and promising directions for further studies of P. linteus.

show abstract

Polysaccharides extracted from Phellinus linteus ameliorate high-fat high-fructose diet induced insulin resistance in mice

Cited by 61 publications

References 56 publications

Phellinus linteus polysaccharide extract improves insulin resistance by regulating gut microbiota composition

Phellinus linteus polysaccharide extract improves insulin resistance by regulating gut microbiota composition

Hypoglycemic and Hypolipidemic Effects of Phellinus Linteus Mycelial Extract from Solid-State Culture in A Rat Model of Type 2 Diabetes

A Review: The Bioactivities and Pharmacological Applications of Phellinus linteus

Contact Info

Product

Resources

About