Polysaccharide from black currant (&lt;i&gt;Ribes nigrum&lt;/i&gt; L.) stimulates dendritic cells through TLR4 signaling

Ashigai, Hiroshi; Komano, Yuta; Wang, Guanying; Kawachi, Yasuji; Sunaga, Kazuko; Yamamoto, Reiko; Takata, Ryoji; Miyake, Mika; Yanai, Takaaki

doi:10.12938/bmfh.16-029

Cited by 2 publications

(3 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…These results indicate that CAPS induces Th-1 type cytokines such as IL-12 and IFN-γ and that they might suppress IgE hyperproduction. In a previous study, we confirmed that CAPS administration stimulates Th-1 type cytokines in DCs through Myd-88 depending on TLR4 signaling [ 19 ]. TLR4 signaling induces Th-1 type cytokines such as IFN-γ and IL-12 [ 23 ].…”

Section: Discussionsupporting

confidence: 76%

“…Dermatitis symptoms were evaluated by the clinical severity score at 0, 7, 14, 21, and 28 days after the first administration of test samples. The clinical severity score was evaluated by a previous method [ 19 ]. The score was defined as the sum of the individual scores graded as 0 (normal), 1 (mild), 2 (moderate), 3 (severe), or 4 (much severe).…”

Section: Methodsmentioning

confidence: 99%

See 1 more Smart Citation

Effect of administrating polysaccharide from black currant (<i>Ribes nigrum</i> L.) on atopic dermatitis in NC/Nga mice

Ashigai

Komano

Wang

et al. 2018

Bioscience of Microbiota, Food and Health

Self Cite

View full text Add to dashboard Cite

Atopic dermatitis (AD) is a chronic inflammatory skin disease that causes dry skin and functional disruption of the skin barrier. AD is often accompanied by allergic inflammation. AD patient suffer from heavy itching, and their quality of life is severely affected. Some pharmaceuticals for AD have some side effects such as skin atrophy. So it is necessary to develop mild solutions such as food ingredients without side effects. There are various causes of AD. It is especially induced by immunological imbalances such as IFN-γ reduction. IFN-γ has an important role in regulating IgE, which can cause an allergy reaction. NC/Nga mice develop AD and IgE hyperproduction. In a previous study, we revealed that administration of polysaccharide from black currant (R. nigrum) has an effect on immunomodulation. It induces IFN-γ production from myeloid dendritic cells. We named this polysaccharide cassis polysaccharide (CAPS). In this report, we studied the effect of administering CAPS on atopic dermatitis in NC/Nga mice. Thirty NC/Nga mice that developed symptoms of atopic dermatitis were used. We divided them into three groups (control, CAPS administration 12 mg/kg/day, CAPS administration 60 mg/kg/day). For 4 weeks, we evaluated clinical score, serum IgE levels, gene expression of spleen, and skin pathology. We revealed that CAPS administration improves atopic dermatitis symptoms. We also found that CAPS administration suppresses IgE hyperproduction and induces IFN-γ gene transcription in the spleen. Finally, we confirmed that CAPS administration suppresses mast cell migration to epidermal skin. These results indicated that CAPS has an effect on AD.

show abstract

Section: Discussionsupporting

confidence: 76%

Section: Methodsmentioning

confidence: 99%

Effect of administrating polysaccharide from black currant (<i>Ribes nigrum</i> L.) on atopic dermatitis in NC/Nga mice

Ashigai

Komano

Wang

et al. 2018

Bioscience of Microbiota, Food and Health

Self Cite

View full text Add to dashboard Cite

show abstract

“…Нині збільшення виробництва продукції садівництва можливе за високої інтенсифікації ягідництва впровадженням інтенсивних агротехнологій з використанням високопродуктивних сортів [1][2][3][4].…”

Section: вступunclassified

The content of chlorophyll in currant leaves as affected by the elements of the agricultural technology

Kopytko¹,

Krotyk²,

Liubych³

et al. 2020

Наукові праці ІБКіЦБ

View full text Add to dashboard Cite

Investigate the formation of baking properties of soft wheat grain with the addition of spelt wheat. Methods. Laboratory, mathematical and statistical, organoleptic, expert. Results. The research results of the grinding process of crushing batches with a percentage of spelt content of 5 %, 10, 15, 20, 25 %, indicate that in the third and fifth samples there is high gluten content-29.6 % and 29.0 %. The lowest number in the fourth sample is 24.8 %. By colour, all samples of the obtained flour is of the highest quality. The results of trial bread baking performed good results. The best flour milling and baking properties were characterized by samples with a percentage of spelt in the amount of 15, 20 and 25 %. The obtained research results scientifically substantiate the expediency of adding spelt wheat to the crushing batches of soft wheat in the amount of 15 % to improve the milling and baking properties. It is when adding 15 % of spelt wheat to the crushing batch of soft wheat that the greatest extraction of flour was obtained, which as a result of trial bread baking showed its high quality. Conclusions. The baking properties of spelt wheat are similar to soft one. The grain of the studied variety of spelt wheat is inferior in volume of bread. It has been found that the adding of 15-20 % of spelt wheat to soft one does not reduce the baking properties of the latter flour. The gluten content is at the level of soft wheat. The volume of bread is 495-506 cm 3. The porosity is 73.0-74.1 %, the persistent shape of hearth bread is 0.32-0.33.

show abstract

Polysaccharide from black currant (<i>Ribes nigrum</i> L.) stimulates dendritic cells through TLR4 signaling

Cited by 2 publications

References 30 publications

Effect of administrating polysaccharide from black currant (<i>Ribes nigrum</i> L.) on atopic dermatitis in NC/Nga mice

Effect of administrating polysaccharide from black currant (<i>Ribes nigrum</i> L.) on atopic dermatitis in NC/Nga mice

The content of chlorophyll in currant leaves as affected by the elements of the agricultural technology

Contact Info

Product

Resources

About