Polysaccharide based metal organic frameworks (polysaccharide–MOF): A review

Nadar, Shamraja S.; Vaidya, Leena B.; Maurya, Shefali S.; Rathod, Virendra K.

doi:10.1016/j.ccr.2019.05.011

Cited by 177 publications

(51 citation statements)

References 112 publications

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“…Cyclodextrin is a safely accepted material that has been studied for the fabrication of the MOF-CyD. [74] The γCyD has a bigger inner cavity which makes it a more favorable cyclodextrin than α and βCyD to obtain the MOF-CyD due to the occurrence of the OCCO functionality in the primary and secondary sites of γCyD which interact with metal ions and form the complex. [75] Hartlieb et al, 2017, have fabricated the γCyD-MOF for the encapsulation of the Ibuprofen where γCyD was used to prepare the porous network that coordinated with the alkali metal (K + ) on primary and secondary sites of the γCyD.…”

Section: Cyclodextrin-metal-organic Framework (Cyd-mofs) Materialsmentioning

confidence: 99%

“…To avoid or minimize the associated toxicity with conventional metal ion and organic ligand, the biocompatible and biodegradable metallic ions such as calcium (Ca), potassium(K), and titanium (Ti) and organic linkers (peptides, carbohydrates, amino acids, and CyD) will be useful. Cyclodextrin is a safely accepted material that has been studied for the fabrication of the MOF‐CyD 74. The γCyD has a bigger inner cavity which makes it a more favorable cyclodextrin than α and βCyD to obtain the MOF‐CyD due to the occurrence of the OCCO functionality in the primary and secondary sites of γCyD which interact with metal ions and form the complex 75.…”

Section: Cyclodextrin—polymer Hydrogel/biomaterialsmentioning

confidence: 99%

See 1 more Smart Citation

Recent Advances in Host–Guest Self‐Assembled Cyclodextrin Carriers: Implications for Responsive Drug Delivery and Biomedical Engineering

Wankar

Kotla

Gera

et al. 2020

Adv Funct Materials

304

195

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This Review is an overview of the unique characteristics of cyclodextrin in forming an inclusion complex via host-guest noncovalent interactions. The modification of cyclodextrin advances its application as a pharmaceutical solubilizer, fabrication of functional molecular machines such as polyrotaxane, polypseudorotaxane, and polycatenanes and grafting of cyclodextrin with different linear, branched chain polymers. The different stimuli-based supramolecular assemblies involving cyclodextrin as a key mediator with linked triggering responses on payload release is highlighted. In addition, the applications of cyclodextrin in diagnostic imaging and medical devices is briefly demonstrated. Cyclodextrin is a relatively low cost, biocompatible, biodegradable, and highly explored material with low toxicity for drug formulation, drug delivery, and wide varieties of other biomedical applications such as those in medical devices fabrication, biosensor, tissue engineering, and bio-imaging. The toxicological profile of cyclodextrin is well established and safe for human consumption in food and medicine.

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Section: Cyclodextrin-metal-organic Framework (Cyd-mofs) Materialsmentioning

confidence: 99%

Section: Cyclodextrin—polymer Hydrogel/biomaterialsmentioning

confidence: 99%

Recent Advances in Host–Guest Self‐Assembled Cyclodextrin Carriers: Implications for Responsive Drug Delivery and Biomedical Engineering

Wankar

Kotla

Gera

et al. 2020

Adv Funct Materials

304

195

View full text Add to dashboard Cite

show abstract

“…Carbohydrates, from simple molecules (e.g., mono- or disaccharides, such as maltose) to complex structures (e.g., polysaccharides, cyclic oligosaccharides as cyclodextrins (CDs)), are a highly desired class of bioligands for MOF synthesis, since they are composed of edible components; thus, their biocompatibility and environmentally friendly nature are strongly highlighted [ 48 ]. Concerning the immobilization of small carbohydrate ligands, maltose has been commonly used.…”

Section: Applications Of Affinity-based Mof Materials In Sample Trmentioning

confidence: 99%

Recent Advances in Affinity MOF-Based Sorbents with Sample Preparation Purposes

2020

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This review summarizes the recent advances concerning metal–organic frameworks (MOFs) modified with several biomolecules (e.g., amino acids, nucleobases, proteins, antibodies, aptamers, etc.) as ligands to prepare affinity-based sorbents for application in the sample preparation field. The preparation and incorporation strategies of these MOF-based affinity materials were described. Additionally, the different types of ligands that can be employed for the synthesis of these biocomposites and their application as sorbents for the selective extraction of molecules and clean-up of complex real samples is reported. The most important features of the developed biocomposites will be discussed throughout the text in different sections, and several examples will be also commented on in detail.

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“…However, ZIF‐based composite becomes biocompatible only when the ZIF framework is grown by incorporating naturally occurring biomolecules, very similar to polysaccharide MOFs, which are derived from naturally occurring polysaccharides such as cellulose, chitin, chitosan, and cyclodextrin. [ 49 ] When using ZIF‐8 and ZIF‐90 as representative framework exoskeletons for loading guest biomolecules, a degradation of the framework will release the incorporated guest enzymes under mild conditions. [ 50 ] This could turn the enzyme@ZIF‐8 as a suitable candidate for the delivery of enzymes in the tumor microenvironment (Figure 4b).…”

Section: Enzyme Biofunctionmentioning

confidence: 99%

Exoskeleton for Biofunctionality Protection of Enzymes and Proteins for Intracellular Delivery

Dutta

2020

Advanced NanoBiomed Research

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Driven by the challenges to protect and restore biofunctionality of enzymes and proteins due to fluctuation of temperature, pH, and solvents, desired tolerances against the intracellular microenvironment can be gained via sheltering enzyme and proteins into nanoscale cages of exoskeleton, one of which involves confinement into the pore and channels of metal–organic frameworks (MOFs). While confining biomolecules, such framework exoskeleton and nanoscale cages should drive the enzyme embedding process and induce the formation of the resulting biocomposite suitable for intracellular delivery for therapeutic applications. Translational challenges faced by framework materials such as ZIF‐8 exoskeleton along with few more MOFs for armoring biofunctionality modulation of enzymes and proteins for intracellular delivery efficiency are highlighted. Herein, enzyme embedding patterns, encapsulation of oxidase enzymes, hybrid protein–MOFs, protected protein delivery, and mechanism of biofunctionality protection are discussed. Furthermore, an attempt is made to highlight the scope of exoskeleton biocomposites.

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Polysaccharide based metal organic frameworks (polysaccharide–MOF): A review

Cited by 177 publications

References 112 publications

Recent Advances in Host–Guest Self‐Assembled Cyclodextrin Carriers: Implications for Responsive Drug Delivery and Biomedical Engineering

Recent Advances in Host–Guest Self‐Assembled Cyclodextrin Carriers: Implications for Responsive Drug Delivery and Biomedical Engineering

Recent Advances in Affinity MOF-Based Sorbents with Sample Preparation Purposes

Exoskeleton for Biofunctionality Protection of Enzymes and Proteins for Intracellular Delivery

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