Recent Advances in Affinity MOF-Based Sorbents with Sample Preparation Purposes

Abstract

This review summarizes the recent advances concerning metal–organic frameworks (MOFs) modified with several biomolecules (e.g., amino acids, nucleobases, proteins, antibodies, aptamers, etc.) as ligands to prepare affinity-based sorbents for application in the sample preparation field. The preparation and incorporation strategies of these MOF-based affinity materials were described. Additionally, the different types of ligands that can be employed for the synthesis of these biocomposites and their application as sorbents for the selective extraction of molecules and clean-up of complex real samples is reported. The most important features of the developed biocomposites will be discussed throughout the text in different sections, and several examples will be also commented on in detail.

Metal-Organic Frameworks: Synthetic Methods and Potential Applications

“…Solid phase extraction (SPE) of biomacromolecules from biological fluids by using MOFs as sorbents is one of the most efficient methods. Well known and thoroughly studied MOFs and composites, such as MIL-53, MIL-100, MIL-101, Fe 3 O 4 @[Cu 3 (btc) 2 ], Fe 3 O 4 @MIL-100/101(Fe), and MIL-101(Cr)-NH 2 , have been successfully used for SPE of low abundance peptides, phosphopeptides, clycopeptides, nucleic acids, and proteins from biological fluids, such as human plasma, urine, serum, saliva, egg white, and milk [ 268 , 269 ]. In addition, MOFs are used as absorbents for sample preparation of food matrices, such as milk, beverages, meat and chicken products, and fish, prior to analysis with chromatographic and spectrometric methods [ 270 ].…”

Novel aspartic-based bio-MOF adsorbent for effective anionic dye decontamination from polluted water

“…10 mg of bio-MOF was mixed with 100 mL from the DR-81 solution at various initial concentrations at 20 C with 400 rpm stirring using a shaking incubator. The adsorption performance of the Zn-L-aspartic MOF was studied through several processing parameters, including contact time (0-180 min), pH (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11), adsorbent dosage (0.25-8 g L À1 ), initial concentration of the pollutant (5-100 mg L À1 ), and reaction temperature (20-85 C). All the adsorption experiments were done in triplicate, and the mean values were utilized in data analysis processes to conrm reliability.…”

“…In addition, amino acids have many functional side groups with different natures, such as charged, aromatic/aliphatic, or hydrophobic/hydrophilic moieties, which are utilized as binding sites for metal ions and aid in maintaining protein functions. 11 Numerous MOFs preparations with different metal ions have been formulated from different amino acids such as L-tryptophan, 12 L-glutamic acid, 13 L-glutamine, 14 Lalanine, 15 L-tyrosine, 16 L-serine, 17 L-glycine, 18 L-histidine, 19 and Laspartic acid. 20 In this study, L-aspartic acid has been chosen as a natural organic ligand (bio-ligand) (NH 2 CH(COOH)CH 2 COOH, aspH 2 ) and zinc metal which displays multiple coordination metal geometries to prepare the targeted bio-MOF.…”

Fabrication of cellulosic paper containing zeolitic imidazolate framework and its application in removal of anionic dye from aqueous solution

“…Metal-organic frameworks (MOFs) have been studied and applicated extensively in the field of gas storage, separation, sensing, and catalysis due to their abundant nanopores (Kim et al 2017;Sun et al 2019;Demakov et al 2020;Pérez-Cejuela et al 2020). The composition of MOFs and other materials is a valuable approach to the development of new materials with better applicability considering the recycling and the improved properties of MOFs (Li et al 2017;Choi et al 2020).…”