Polysaccharide-based hydrogel promotes skin wound repair and research progress on its repair mechanism

Zhang, Shuai; Liu, Hongyuan; Li, Wei; Liu, Xinglong; Ma, Lina; Zhao, Ting; Ding, Qiteng; Ding, Chuanbo; Liu, Wencong

doi:10.1016/j.ijbiomac.2023.125949

Cited by 15 publications

(2 citation statements)

References 154 publications

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“…Therefore, hydrogels, which combine drug release rate, cells, cytokines and other substances, are evaluated as a valuable drug delivery system for wound healing. [14,15] Hyaluronic acid (HA) as a natural non-branched polymer shows intriguing viscoelastic properties, good biocompatibility, biodegradability, and non-immunogenicity, and it can be gradually degraded in the presence of hyaluronidase and reactive oxygen species (ROS). [16][17][18] Meanwhile, HA-based hydrogels show well wound healing after chemically transformed or modified, and applications in tissue engineering, drug delivery and bioinstrumentation, especially on wound healing.…”

Section: Introductionmentioning

confidence: 99%

pH‐Responsive Calcium Ions and Crocetin Releasing Hydrogel for Accelerating Skin Wound Healing

Wang,

Ma,

Pan

et al. 2024

Chemistry An Asian Journal

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The ideal and highly anticipated dressing for skin wounds should provide a moist environment, possess antibacterial properties, and ensure sustained drug release. In the present work, a pH‐responsive hyaluronic acid‐based hydrogel (CPC@HA hydrogel) was formed by hydrogen bond and amido bond cross‐linking after introducing crocetin (Cro) and CaCO3@polyelectrolyte microspheres (CaCO3@PEM) to HA hydrogel to sustained, controlled release of the calcium ions and crocetin under slightly acid to accelerating skin wounds healing. The experiment results showed that the CPC@HA hydrogel exhibited porous network structures, stable physical properties, and had antibacterial properties and biocompatibility in vitro. In addition, the CPC@HA hydrogel covering on the skin wound could reduce inflammation and promote wound healing. The high expression of angiogenic cytokines (CD31) and epidermal terminal differentiation markers (Loricrin) of wound healing tissue suggested the CPC@HA hydrogel also had the function of promoting the remodeling of regenerated skin. Overall, CPC@HA hydrogel has promising potential for clinical applications in accelerated skin wound repair.

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Section: Introductionmentioning

confidence: 99%

pH‐Responsive Calcium Ions and Crocetin Releasing Hydrogel for Accelerating Skin Wound Healing

Wang,

Ma,

Pan

et al. 2024

Chemistry An Asian Journal

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show abstract

“…It protects internal organs and tissues from external-environmental influences. 1–3 Once injured, it is easy to introduce bacteria and even reduce the maintenance of body fluids. Wound dressings can generally complete hemostasis and provide temporary protection after skin damage.…”

Section: Introductionmentioning

confidence: 99%

Fabrication of a MXene-based shape-memory hydrogel and its application in the wound repair of skin

Hu,

Xie,

Peng

et al. 2024

Soft Matter

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Research progress on the application of inkjet printing technology combined with hydrogels

Wu,

Zhang,

Yan

et al. 2024

Applied Materials Today

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Polysaccharide-based hydrogel promotes skin wound repair and research progress on its repair mechanism

Cited by 15 publications

References 154 publications

pH‐Responsive Calcium Ions and Crocetin Releasing Hydrogel for Accelerating Skin Wound Healing

pH‐Responsive Calcium Ions and Crocetin Releasing Hydrogel for Accelerating Skin Wound Healing

Fabrication of a MXene-based shape-memory hydrogel and its application in the wound repair of skin

Research progress on the application of inkjet printing technology combined with hydrogels

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