Polypyrrole Nanoparticles: A Potential Optical Coherence Tomography Contrast Agent for Cancer Imaging

Au, Kin Man; Lu, Zenghai; Matcher, Stephen J.; Armes, Steven P.

doi:10.1002/adma.201103190

Cited by 95 publications

(59 citation statements)

References 41 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…[ 25 , 26 ] With strong NIR absorbance, PPy nanoparticles were used by Armes et al as a contrast agent for optical coherence tomography (OCT), signifi cantly improving OCT imaging sensitivity and facilitating the earlystage detection of cancers. [ 27 ] PPy nanomaterials have also been used in biosensors, drug delivery and nerve regeneration. [28][29][30][31][32][33] Although it has been reported that PPy can act as a thermal transducer of NIR radiation, [ 34 ] the potential use of PPy conductive polymers for photothermal treatment of cancer has, to the best of our knowledge, not yet been reported.…”

mentioning

confidence: 99%

In Vitro and In Vivo Near‐Infrared Photothermal Therapy of Cancer Using Polypyrrole Organic Nanoparticles

et al. 2012

View full text Add to dashboard Cite

mentioning

confidence: 99%

In Vitro and In Vivo Near‐Infrared Photothermal Therapy of Cancer Using Polypyrrole Organic Nanoparticles

et al. 2012

View full text Add to dashboard Cite

“…These methods upgrade photothermal PPy nanocomposites to theranostic agents and enable the accumulation of concentrations in diseased areas sufficient to be visualized for both imaging and therapy purposes. In contrast to the MRI and ultrasound results, the intrinsic NIR absorption band of the PPy NPs enabled their use as a powerful biophotonics platform using the optical imaging modalities of optical coherence tomography 82 and PA technology 83 for tumor imaging. By exploiting NIR laser light and PPy optical contrast agents, a tissue treatment depth of~4.3 cm was achieved.…”

Section: Polymer Npsmentioning

confidence: 99%

Revisiting the classification of NIR-absorbing/emitting nanomaterials for in vivo bioapplications

et al. 2016

View full text Add to dashboard Cite

With the development of nonlinear optics and new imaging methods, near-infrared (NIR) light can excite contrast agents to probe biological specimens both functionally and structurally with a deeper imaging depth and a higher spatial resolution than linear optical approaches. There is considerable and growing interest in how biological specimens respond to NIR light. Moreover, the visible absorption band of most functional nanomaterials becomes NIR-excitable through multiphoton processes, thus allowing multifunctional imaging and combined therapy with noble metal and magnetic nanoparticles both in vitro and in vivo. A groundbreaking example is the use of different laser techniques to excite single-type NIR-absorbing/emitting nanomaterials to produce multiphoton emission by femtosecond lasers using either a remote control system for photodynamic therapy or photo-induced chemical bond dissociation. These techniques provided superior anatomical resolution and detection sensitivity for in vivo tumor-targeted imaging than those offered by conventional methods. Here we summarize the most recent progress in the development of smart NIR-absorbing/emitting nanomaterials for in vivo bioapplications.

show abstract

“…Encouraged by the in vivo animal studies that low concentrations of PPy NPs (<200 μg mL −1 ) have very low long-term cytotoxicity26, PPy NPs have been demonstrated as an attractive OCT-absorbing (optical coherence tomography) contrast agent for tumor imaging27 and photothermal agent with high photothermal conversion efficiency for tumor ablation28 owing to the strong NIR absorption spectrum. Due to the truth that typical UCA is based upon microscale bubbles which are effective scatters of ultrasound waves29, it is highly desired to develop biocompatible NIR-absorbing PPy hollow microspheres (PPyHMs) with outstanding US-responsive capability for US imaging guided PTT.…”

mentioning

confidence: 99%

Polypyrrole Hollow Microspheres as Echogenic Photothermal Agent for Ultrasound Imaging Guided Tumor Ablation

Zha

Wang

et al. 2013

Sci Rep

View full text Add to dashboard Cite

Ultrasound (US) imaging provides a valuable opportunity to administer photothermal therapy (PTT) of cancer with real-time guidance to ensure proper targeting, but only a few theranostic agents were developed by physically grafting near infrared (NIR)-absorbing inorganic nanomaterials to ready-made ultrasound contrast agents (UCAs) for US imaging guided PTT. In this paper, NIR absorbing hollow microspheres were generated from polypyrrole merely using a facile one-step microemulsion method. It was found that the obtained polypyrrole hollow microspheres (PPyHMs) can act as an efficient theranostic agent not only to enhance US imaging greatly, but also exhibit excellent photohyperthermic effects. The contrast consistently sustained the echo signals for no less than 5 min and the NIR laser light ablated the tumor completely within two weeks in the presence of PPyHMs. More importantly, no use of additional NIR absorber substantially minimizes an onetime dose of the theranostic agent.

show abstract

Polypyrrole Nanoparticles: A Potential Optical Coherence Tomography Contrast Agent for Cancer Imaging

Abstract: A near-infrared (NIR) absorbing contrast agent based on polypyrrole nanoparticles is described. Quantitative optical coherence tomography studies on tissue phantoms and Mie scattering calculations indicate their potential application for early-stage cancer diagnosis.

Cited by 95 publications

References 41 publications

In Vitro and In Vivo Near‐Infrared Photothermal Therapy of Cancer Using Polypyrrole Organic Nanoparticles

In Vitro and In Vivo Near‐Infrared Photothermal Therapy of Cancer Using Polypyrrole Organic Nanoparticles

Revisiting the classification of NIR-absorbing/emitting nanomaterials for in vivo bioapplications

Polypyrrole Hollow Microspheres as Echogenic Photothermal Agent for Ultrasound Imaging Guided Tumor Ablation

Contact Info

Product

Resources

About