In Vitro and In Vivo Near‐Infrared Photothermal Therapy of Cancer Using Polypyrrole Organic Nanoparticles

Yang, Kai; Xu, Huan; Cheng, Liang; Sun, Chunyang; Wang, Jun; Liu, Zhuang

doi:10.1002/adma.201202625

Cited by 712 publications

(545 citation statements)

References 44 publications

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“…[6][7][8][9][10][11][12] Many materials such as carbon nanotubes, graphene oxide (GO) sheets, gold nanorods, and conjugated polymeric nanomaterials all exhibit considerable photothermal conversion effects. [13][14][15][16][17] However, carbon nanotubes and GO sheets have low degradability in vivo, whereas gold nanorods face the drawbacks of toxicity and high cost. Polymeric nanomaterials such as polypyrrole will not be easily dispersed in an aqueous solution.…”

Section: Introductionmentioning

confidence: 99%

Highly effective photothermal chemotherapy with pH-responsive polymer-coated drug-loaded melanin-like nanoparticles

Zhang¹,

Zhao²,

Guo³

et al. 2017

IJN

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Dopamine is a neurotransmitter commonly used in clinical treatment. Polydopamine (PDA) has excellent histocompatibility and biosafety and can efficiently convert near-infrared reflection (NIR) to thermal energy. In this study, PDA was used as a promising carrier, and pH-responsive polymer-coated drug-loaded PDA nanoparticles (NPs; doxorubicin@ poly(allylamine)-citraconic anhydride [Dox@PAH-cit]/PDA NPs) were developed. As expected, the Dox@PAH-cit/PDA NPs exhibited excellent photothermal efficiency. In addition, at a low pH condition, the loaded Dox was released from the NPs due to the amide hydrolysis of PAH-cit. Upon NIR exposure (808 nm), the temperature of the NP solution rapidly increases to kill tumor cells. Compared with unbound chemotherapy drugs, the NPs have a stronger cell uptake ability. In vivo, the PDA NPs were able to efficiently accumulate at the tumor location. After intravenous administration and NIR exposure, tumor growth was significantly inhibited. In summary, the present investigation demonstrated that the Dox@PAH-cit/PDA NPs presented highly effective photothermal chemotherapy for prostate cancer.

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Section: Introductionmentioning

confidence: 99%

Highly effective photothermal chemotherapy with pH-responsive polymer-coated drug-loaded melanin-like nanoparticles

Zhang¹,

Zhao²,

Guo³

et al. 2017

IJN

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“…4 Inorganic nanotheranostic agents, including noble metals, 5,6 semiconductor NPs, 7,8 and carbon materials, [9][10][11] are studied extensively, as they are highly stable and have multifunctional properties. However, inorganic materials do not degrade, and long-term retention in the body limits their clinical use for cancer treatments, 12 since agents must completely clear the body within a reasonable period to receive regulatory approval from the US Food and Drug Administration (FDA). 13 Given the pitfalls of inorganic materials, an increasing number of organic nanotheranostic platforms are under intense investigation.…”

Section: Introductionmentioning

confidence: 99%

BSA-assisted synthesis of ultrasmall gallic acid–Fe(III) coordination polymer nanoparticles for cancer theranostics

Mu¹,

Yan²,

Tian³

et al. 2017

IJN

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Protein-related nanotheranostic agents hold great promise as tools to serve many clinical applications. Proteins such as BSA are used to regulate the synthesis of nondegradable inorganic nanoparticles (NPs). To fully employ the potential of such proteins, a new type of biosafe nanotheranostic agent must be designed to optimize BSA as a biomineralization agent. Here, a straightforward BSA-assisted biomineralization method was developed to prepare gallic acid (GA)–Fe(III) coordination polymer NPs. BSA-coated GA-Fe (GA-Fe@BSA) NPs were ultrasmall (3.5 nm) and showed good biocompatibility, a lower r 2 : r 1 ratio (1.06), and strong absorption in the visible near-infrared region. T 1 -weighted magnetic resonance imaging of tumor-bearing mice before and after intratumoral injection with GA-Fe@BSA NPs definitively demonstrated positive change. In a subsequent in vivo study, antitumor activity was precipitated by intratumoral injection of GA-Fe@BSA NPs combined with laser treatment, suggesting excellent outcomes with this treatment method. These results describe a successful protocol in which BSA regulated the synthesis of benign organic polymer NPs. GA-Fe@BSA NPs have the potential to be ideal agents to be used in clinical theranostic nanoplatforms.

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“…Indeed, nanoparticles based on conjugated polymers are emerging as multifunctional nanoscale materials that promise great potentials. [27][28][29][30][31][32][33] Here we report that the use of Rozen's reagent, one of the most powerful oxygen transfer agents, [8][9][10][11] allows for the preparation of poly(3-hexylthiophene-S,S-dioxide) nanoparticles, whose properties can be skillfully tuned through the controlled introduction of TDO moieties before or after the formation of poly(3-hexylthiophene) nanoparticles. The different modalities of introduction of TDO moieties causes the formation of either PTDO-NPs obtained from pre-oxygenated P3HT, with dimensions down to 5 nm, or core-shell P3HT@PTDO-NPs obtained from oxygenation of the surface of preformed P3HT nanoparticles.…”

mentioning

confidence: 99%

Poly(3-hexylthiophene) Nanoparticles Containing Thiophene-S,S-dioxide: Tuning of Dimensions, Optical and Redox Properties, and Charge Separation under Illumination

et al. 2017

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We describe the preparation of poly(3-hexylthiophene-S,S-dioxide) nanoparticles using Rozen's reagent, HOF•CH 3 CN, either on poly(3-hexylthiophene) (P3HT) or on preformed P3HT nanoparticles (P3HT-NPs). In the latter case, core−shell nanoparticles (P3HT@PTDO-NPs) are formed, as confirmed by X-ray photoelectron spectroscopy measurements, indicating the presence of oxygen on the outer shell. The different preparation modalities lead to a finetuning of the chemical−physical properties of the nanoparticles. We show that absorption and photoluminescence features, electrochemical properties, size, and stability of colloidal solutions can be finely modulated by controlling the amount of oxygen present. Atomic force microscopy measurements on the nanoparticles obtained by a nanoprecipitation method from preoxidized P3HT (PTDO-NPs) display spherical morphology and dimensions down to 5 nm. Finally, Kelvin probe measurements show that the coexistence of p-and n-type charge carriers in all types of oxygenated nanoparticles makes them capable of generating and separating charge under illumination. Furthermore, in core−shell nanoparticles, the nanosegregation of the two materials, in different regions of the nanoparticles, allows a more efficient charge separation.

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In Vitro and In Vivo Near‐Infrared Photothermal Therapy of Cancer Using Polypyrrole Organic Nanoparticles

Cited by 712 publications

References 44 publications

Highly effective photothermal chemotherapy with pH-responsive polymer-coated drug-loaded melanin-like nanoparticles

Highly effective photothermal chemotherapy with pH-responsive polymer-coated drug-loaded melanin-like nanoparticles

BSA-assisted synthesis of ultrasmall gallic acid–Fe(III) coordination polymer nanoparticles for cancer theranostics

Poly(3-hexylthiophene) Nanoparticles Containing Thiophene-S,S-dioxide: Tuning of Dimensions, Optical and Redox Properties, and Charge Separation under Illumination

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In Vitro and In Vivo Near‐Infrared Photothermal Therapy of Cancer Using Polypyrrole Organic Nanoparticles

Cited by 712 publications

References 44 publications

Highly effective photothermal chemotherapy with pH-responsive polymer-coated drug-loaded melanin-like nanoparticles

Highly effective photothermal chemotherapy with pH-responsive polymer-coated drug-loaded melanin-like nanoparticles

BSA-assisted synthesis of ultrasmall gallic acid&ndash;Fe(III) coordination polymer nanoparticles for cancer theranostics

Poly(3-hexylthiophene) Nanoparticles Containing Thiophene-S,S-dioxide: Tuning of Dimensions, Optical and Redox Properties, and Charge Separation under Illumination

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BSA-assisted synthesis of ultrasmall gallic acid–Fe(III) coordination polymer nanoparticles for cancer theranostics