Polypropylene mesh seeded with fibroblasts: A new approach for the repair of abdominal wall defects in rats

Mohsina, A; Kumar, Naveen; Sharma, Ashok; Shrivastava, Sameer; Mathew, Dayamon David; Remya, V.; Sonal,; Maiti, Swapan Kumar; Singh, Kiranjeet

doi:10.1016/j.tice.2017.04.004

Cited by 17 publications

(17 citation statements)

References 28 publications

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“…Likewise, wound complications such as seroma and infections were not reported by Aramayo, et al [37] and Mohsina, et al [38]. In this context, biological prosthesis seems to be a valid option for abdominal wall repair sice minimize mesh-related complications [9].…”

Section: Discussionmentioning

confidence: 99%

Heterologous Bovine Tunica Albuginea Graft Conserved in Honey as Abdominal Wall Reinforcement in Rats

Medeiros¹,

Ferreira²,

Castañon³

et al. 2020

OJVM

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Complex abdominal wall defects might be challenging for human and veterinary surgeons worldwide. Defects from trauma or congenital causes may lead to hernias development. The introduction of meshes to reinforce hernia repairs has improved surgical outcomes and several synthetic and biologic materials have been used. In this context, biomaterial prosthesis seems to be a satisfactory solution when managing great abdominal wall defects. The aim of the current study is to evaluate the bovine tunica albuginea (BTA) preserved in honey as graft material for rats' abdominal wall reinforcement in incisional herniorrhaphy surgery as well as its viability, cicatrization and integration into the host tissue. Wistar rats were assigned to two main groups: 1) animals (n = 20) underwent median longitudinal laparotomy followed by laparorraphy with suture of the bovine tunica albuginea (BTA) graft as abdominal wall reinforcement; and 2) animals (n = 20) underwent only laparotomy and subsequent laparorrhaphy. Rats were clinically evaluated until euthanasia at post-surgical day 7, 14, 21 and 28. Necropsy and histopathological analysis of abdominal wall fragments were performed to compare groups and subgroups findings. BTA promoted abundant fibrosis, providing resistance and low postoperative complication rates. Besides, animals did not show rejection signs to the implant. In conclusion, BTA preserved in honey is an affordable, easy collection and handling biomaterial for graft, demanding simple surgical implantation technique for abdominal wall repair in rats.

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Section: Discussionmentioning

confidence: 99%

Heterologous Bovine Tunica Albuginea Graft Conserved in Honey as Abdominal Wall Reinforcement in Rats

Medeiros¹,

Ferreira²,

Castañon³

et al. 2020

OJVM

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“…To repair hernias, eventroplasty with a nonresorbable synthetic or biological prosthesis is the gold standard in treatment to resolve an eventration (Deeken, Abdo, Frisella, & Matthews, ; Deeken, Faucher, Matthews, ; Deeken, Abdo, Frisella, & Matthews, ; Deeken & Lake, ). Currently, the most commonly used material in prostheses is polypropylene (Mohsina et al, ; Qiu et al, ). However, the properties that serve polypropylene well for incorporation after hernia repair can also be detrimental.…”

Section: Discussionmentioning

confidence: 99%

“…The use of prosthetic materials in hernia repair has become widespread in the last decade. Biological materials (skin or muscle aponeurosis) and synthetic materials have been used, with polypropylene being the most common (Mohsina et al, ). These prostheses may be over‐engineered or too strong, resulting in intense inflammation, retraction of the mesh, and loss of abdominal wall compliance (Cobb, Kercher, & Heniford, ; Qiu et al, ).…”

Section: Introductionmentioning

confidence: 99%

Proof of concept, design, and manufacture via 3‐D printing of a mesh with bactericidal capacity: Behaviour in vitro and in vivo

Castro

Yuste

Pereira

et al. 2019

J Tissue Eng Regen Med

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Currently, hernia treatment involves implantation of a mesh prosthesis, usually made of polypropylene, and the primary complication is infection of the device, which leads to an exponential increase in morbidity. Three-dimensional printing offers a method of dealing with complications of this magnitude. Therefore, in this study, the bactericidal properties and effectiveness of three-dimensional-printed meshes with polycaprolactone (PCL) and gentamicin were evaluated in vitro in Escherichia coli cultures, and their histological behaviour was examined in vivo. Different PCL meshes were implanted into four groups of rats, with 10 rats in each group: PCL meshes, PCL meshes with alginate and calcium chloride, PCL meshes with gentamicin, and PCL meshes with alginate and gentamicin. Thirty-six microporous meshes were manufactured, and their bactericidal properties were assessed. When the meshes did not include an antibiotic, an inhibition halo was not observed; when the gentamicin was free, an asymmetric inhibition area of 5.65 ± 0.46 cm 2 was present; when the gentamicin was encapsulated, a rectangular area of 5.40 ± 0.38 cm 2 was observed. In the rats, macroporous and microporous mesh implants produced mild inflammation and substantial fibrosis with collagen and neovascular foci. A significant difference was observed in fibroblastic activity between the PCL with alginate group and the PCL with alginate and gentamicin group microporous meshes (p = .013) and in collagen deposits between the macroporous and microporous meshes in the PCL mesh group (p = .033). The feasibility of manufacturing drug-doped printed PCL meshes containing alginate and gentamicin was verified, and the meshes exhibited bactericidal effects and good histopathological behaviour.

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“…A hernia could be repaired in different methods according to the size and location of the hernia. Firstly, a hernia reconstructs by primary closure by approximation the edge of hernia ring (herniorrhaphy) this method has some drawbacks as delay or non-healing as well as the incidence of recurrence (5). Various synthetic Iraqi Journal of Veterinary Sciences, Vol.…”

Section: Introductionmentioning

confidence: 99%

An evaluation of Aloe vera leaves gel with polypropylene mesh to repair of ventro -lateral abdominal hernia in rams

Zedan¹,

Alkattan²,

Aliraqi³

2022

IJVS

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The presented article was designed to evaluate using polypropylene mesh alone and using Aloe vera gel for hernioplasty in rams. Under the protocol of sedations, local anesthesia, and strict surgical preparations, the 10 cm of experimental ventrolateral abdominal hernias were surgically induced in twenty-four rams. The animals were divided into two equal groups. Hernioplasty was done with polypropylene mesh in both groups. The first group remained without treatment and was considered the control group. In the second group, after hernioplasty the Aloe vera leaf gel spread equally along the repaired area, then the skin and subcutaneous tissues closed routinely. Clinical, Ultrasonographic, and Laparoscopic examinations were done. Clinically, all operative animals completely subsided the hernia ring. Laparoscopically, the results indicated less degree of adhesion and inflammatory reaction were occurs in the treated group at 45 days post-surgery. Ultrasonographic investigation in the control group at 30 days post-surgery exhibited Wavy echogenic representing inflammatory effusion. It represented Hypoechoic at muscle mass and mesh at 45 days, whereas in the treated group, the subcutaneous tissue appeared normal echotexture with a clear mesh at 45 days post-treatment. In conclusion, compatibility occurs between the implant and the edges of the hernia ring without signs of rejection, less degree of adhesion, and the hernia opening completely closed. The Aloe vera gel had a beneficial effect during hernioplasty in the ram.

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Polypropylene mesh seeded with fibroblasts: A new approach for the repair of abdominal wall defects in rats

Cited by 17 publications

References 28 publications

Heterologous Bovine Tunica Albuginea Graft Conserved in Honey as Abdominal Wall Reinforcement in Rats

Heterologous Bovine Tunica Albuginea Graft Conserved in Honey as Abdominal Wall Reinforcement in Rats

Proof of concept, design, and manufacture via 3‐D printing of a mesh with bactericidal capacity: Behaviour in vitro and in vivo

An evaluation of Aloe vera leaves gel with polypropylene mesh to repair of ventro -lateral abdominal hernia in rams

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