Polypropylene mesh for nasal septal perforation repair: an experimental study

Abstract

The aim of this study is to determine the effectiveness and biocompatibility of polypropylene mesh for the repair of nasal septal perforations in an animal model on rabbits. A full-thickness nasal septal perforation with a diameter of nearly 10 × 10 mm was created on 12 rabbits, and then the perforation was reconstructed with two different methods. We used mucosal flaps and polypropylene mesh as an interpositional graft in group 1. Only mucosal flaps were used for reconstruction and are identified as group 2. After 4 weeks, we removed the nasal septum of the rabbits and performed histopathological examinations for acute rejection, infection, inflammatory response, fibrosis, and granuloma formation. We found perforation closure rates of 75 and 25 % in groups 1 and 2, respectively. Inflammatory response was seen in all specimens of group 1 (100 %). The inflammatory response was +1 in five of the specimens (62.5 %), +2 in one specimen (12.5 %), and +3 in two specimens (25 %). Mild fibrosis around the mesh was detected in four specimens (50 %), medium-level fibrosis was detected in one (12.5 %), and no fibrosis was detected in three (37.5 %). Severe fibrosis was not seen in any specimens. The foreign-body reaction was limited to a few giant cells, and granuloma formation was seen in two specimens (25 %). The propylene mesh showed excellent biocompatibility with the septal mucosa, and it can, therefore, be used for the repair of septal perforation as an interpositional graft safely.

Biomaterials in the Reconstruction of Nasal Septum Perforation

“…Technical difficulties, the lack of an appropriate quantity of material, and the low success rate in treating large and very large septal nasal perforations prompted the search for alternative solutions and materials. [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15] On-going research into biostable and resorbable biomaterials allowed selection of the best materials that could replace autografts, including titanium plates, 16 polypropylene meshes, 17 polydioxanone plates, 18 biostable terpolymer PTFE/PVD/PP and resorbable poly(lactic-coglycolic acid (PGLA). 19 The search for material suitable for septal perforation reconstruction is currently on-going.…”

Porcine Tracheal Mucosa-Derived Decellularized Patch to Prevent Septal Perforation in a Rabbit Model

“…9 , 14 , 18 , 27 However, AlloDerm use has the risk of contracting transmissible infections and inflammation. 9 , 14 , 18 , 27 Yücebaş et al. 27 investigated the use of a polypropylene mesh as an interpositional graft material for repairing septal perforations.…”

“…9 , 14 , 18 , 27 Yücebaş et al. 27 investigated the use of a polypropylene mesh as an interpositional graft material for repairing septal perforations. Although biocompatible, it yielded only 75% perforation closure rate.…”

The Effect of Platelet-Rich Fibrin and Hyaluronic Acid on Perforation of Nasal Septum

“…All perforations were made using a previously prepared 0.7 × 0.7 cm guide. [13][14][15] All groups had perforation of the same size because of this method. These perforations were made in the remaining area, leaving 0.5 cm gap from the anterior, inferior, and superior.…”