Polyphenols in Health and Disease

Zhang, Pei-Ying

doi:10.1007/s12013-015-0558-z

Cited by 37 publications

(31 citation statements)

References 175 publications

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“…With this in mind, we tested whether, besides tea and coffee, press residues of red grapes might serve as sources of polyphenol extracts. The skin of red grapes is of particular interest due to its high resveratrol content, which is responsible for both anticancer activities, including cell-cycle effects and anti-inflammatory effects [30]. In an animal experiment, wine lees were shown to be a rich source of polyphenols as a basis for functional food without alcohol.…”

Section: Discussionmentioning

confidence: 99%

A Micromethod for Polyphenol High-Throughput Screening Saves 90 Percent Reagents and Sample Volume

et al. 2019

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There is ample evidence that polyphenols are important natural substances with pronounced antioxidative properties. This study aimed to develop a fast and reliable method to determine total polyphenol content (TPC) in foodstuffs and human samples. The microtitration format offers the advantage of low sample volumes in the microlitre range, facilitating high-throughput screening with 40 samples simultaneously. We accordingly adjusted the so-called Folin–Ciocalteu method to a microtitre format (polyphenols microtitre—PPm) with 90% reduction of reagents. The assay was standardized with gallic acid in the range between 0.1 and 3 mM, using a 20 µL sample volume. The intra-assay coefficient of variation (CV) was less than 5%, and inter-assay CV was in the range of 10%. Wavelength was measured at 766 nm after two hours of incubation. This micromethod correlates significantly with both the classical Folin–Ciocalteu method and High-Performance Thin-Layer Chromatography (HPTLC) (r2 = 0.9829). We further observed a significant correlation between PPm and total antioxidants (r2 = 0.918). The highest polyphenol concentrations were obtained for red, blue, and black fruits, vegetables, and juices. Extracts of red grapes could be harvested almost sugar free and might serve as a basis for polyphenol supplementation. Beer, flour, and bread contained polyphenol concentrations sufficient to meet the minimal daily requirement. We conclude that PPm is a sensitive and reliable method that detects polyphenols even in samples diluted 10-fold. The literature strongly recommends further investigations on the effects of polyphenol uptake on human and animal health.

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Section: Discussionmentioning

confidence: 99%

A Micromethod for Polyphenol High-Throughput Screening Saves 90 Percent Reagents and Sample Volume

et al. 2019

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“…Their potential role in the prevention and treatment of oxidative stress and inflammation has been investigated recently. [21] In particular, polyphenols may present hepatoprotective effects by increasing the fatty acid oxidation and modulation of insulin resistance, oxidative stress and inflammation, which are the main pathogenetic factors linked to the progression from simple fat accumulation to NASH. [20] Several evidences in vitro, pre-clinical and emerging clinical trials reported beneficial effects on liver steatosis and its pathogenic and clinical setting.…”

Section: Polyphenols and Nafldmentioning

confidence: 99%

“…[20] Several evidences in vitro, pre-clinical and emerging clinical trials reported beneficial effects on liver steatosis and its pathogenic and clinical setting. [20][21][22][23] Few clinical studies were focused on the polyphenols use in NAFLD patients. Three were undertaken with 500 mg and 600 mg resveratrol daily for 12 weeks, or 3000 mg daily for 8 weeks respectively.…”

Section: Polyphenols and Nafldmentioning

confidence: 99%

Polyphenols treatment in patients with nonalcoholic fatty liver disease

Abenavoli

Milić

Luzza

et al. 2017

Journal of Translational Internal Medicine

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Nonalcoholic fatty liver disease (NAFLD) affects 25−30% of the general population worldwide and this high prevalence is linked with lifestyle and dietetic changes, not only in Western countries, but also in the urban areas of developing countries. Several pharmacological approaches were proposed in the treatment of NAFLD, but the reported results are inconclusive. International guidelines recommended the reduction of dietary fat and fructose, in association with some physical activity. In this context, it was reported that the protective effects of traditional Mediterranean diet, related to the high concentration of antioxidant compounds, particularly of polyphenols. Polyphenols are a heterogeneous class of plant derived compounds, with some proven hepatoprotective effects. Our opinion is that the adherence to traditional Mediterranean diet characterized by the consumption of antioxidant-rich foods in general and of polyphenols in particular, can be considered as a potential new approach in the treatment of NAFLD.

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“…Indeed, since polyphenols act as hydrogen donators, singlet oxygen quenchers or chelators, they are considered antioxidant agents (Zhang, 2015). Hence, we have determined the total polyphenol content (TPC) from 'Gallo Matese' beans collected from C1 site available in larger quantities for this biochemical characterization, extracted by using a rotary shaker and acetone/water as extractants.…”

Section: Anti-proteinase Inhibitor Activitymentioning

confidence: 99%

Nutritional values and metabolic profile with and without boiled treatment of 'Gallo Matese' beans (Phaseolus vulgaris L.), a landrace from Southern Italy

Ragucci

Fiorentino

Guida

et al. 2017

Acta Sci Pol Technol Aliment

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Background. 'Gallo Matese' beans are known as a typical legume of Southern Italy and continue to be consumed as a traditional food preserving the diversity of this region. Nonetheless, no information about the nutritional values of this legume is available. The objective of the present investigation was to determine the nutritional value and metabolic profile of 'Gallo Matese' beans. Results. 'Gallo Matese' beans contain high levels of proteins (22.64 g/100 g) and essential amino acids (8.3 g/100 g). Furthermore, different unsaturated fatty acids contribute to the total amount of lipids (0.97 g/100 g); among them, the essential PUFA α-linolenic (0.48 g/100 g) and linoleic (0.39 g/100 g) acids are the most abundant. The total phenol content was revealed and ABTS and ORAC-fluorescein methods were applied to determine the radical scavenging capabilities of the extract with and without boiled treatment. Finally, a decrease in trypsin and chymotrypsin inhibitory activities was estimated before and after the boiling procedure. Conclusion. The data obtained show that 'Gallo Matese' beans are a functional food with healthy qualities. Overall, these results are useful to promote their cultivation and consumption, thus preserving Italian beans biodiversity due to consumer interest in choosing a healthy diet, such as the Mediterranean diet.

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Polyphenols in Health and Disease

Cited by 37 publications

References 175 publications

A Micromethod for Polyphenol High-Throughput Screening Saves 90 Percent Reagents and Sample Volume

A Micromethod for Polyphenol High-Throughput Screening Saves 90 Percent Reagents and Sample Volume

Polyphenols treatment in patients with nonalcoholic fatty liver disease

Nutritional values and metabolic profile with and without boiled treatment of 'Gallo Matese' beans (Phaseolus vulgaris L.), a landrace from Southern Italy

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