Polyphenols treatment in patients with nonalcoholic fatty liver disease

Abenavoli, Ludovico; Milić, Nataša; Luzza, Francesco; Boccuto, Luigi; Lorenzo, Antonino De

doi:10.1515/jtim-2017-0027

Cited by 42 publications

(31 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Recent attention has focused on the control of pathogenesis for fatty liver diseases using micronutrient antioxidants and/or dietary components, such as vitamins, ATX, NAC, resveratrol, carotenoid, curcumin, betaine, and polyphenols [ 2 , 8 , 9 , 10 , 11 , 12 , 13 , 15 ]. Among them, polyphenols are a heterogeneous class of plant derived compounds, with some proven hepatoprotective effects [ 19 ]. Vitamins C and E are known to react with ROS to block the propagation of radical reactions in oxidative stress-related situations [ 2 , 4 ].…”

Section: Discussionmentioning

confidence: 99%

Effects of Antioxidants in Reducing Accumulation of Fat in Hepatocyte

Yang

Shin

Seo

et al. 2018

IJMS

View full text Add to dashboard Cite

The progress of the hepatic steatosis (HS), a clinicopathological status, is influenced by cellular oxidative stress, lipogenesis, fatty acid (FA) oxidation, and inflammatory responses. Because antioxidants are gaining attention as potent preventive agents for HS, we aimed to investigate anti-lipogenic effects of the antioxidants vitamin C (VC), N-acetylcysteine (NAC), and astaxanthin (ATX) using hepatocytes. For this, we established an in vitro model using 1 mM oleic acid (OA) and human liver hepatocellular carcinoma (HepG2) cells; 10 μM antioxidants were evaluated for their ability to reduce fat accumulation in hepatocytes. Our results showed that all three antioxidants were effective to reduce fat accumulation for the molecular targets such as reduction in lipid droplets, triglyceride (TG) concentration, reactive oxygen species (ROS) production, and cell apoptosis, as well as in gene expressions of endoplasmic reticulum (ER) stress-related effectors, lipogenesis, and inflammatory cytokines. There were simultaneous increases in diphenyl-1-picrylhydrazyl (DPPH) radical scavenging effect, cell survival, AMPK phosphorylation, NRF2-related gene expression for cellular defense, and FA β-oxidation. However, among these, ATX more effectively inhibited ER stress and lipogenesis at the intracellular level than VC or NAC. Consequently, ATX was also more effective in inhibiting cell death, lipotoxicity, and inflammation. Our result emphasizes that ATX achieved greater lipotoxicity reduction than VC and NAC.

show abstract

Section: Discussionmentioning

confidence: 99%

Effects of Antioxidants in Reducing Accumulation of Fat in Hepatocyte

Yang

Shin

Seo

et al. 2018

IJMS

View full text Add to dashboard Cite

show abstract

“…This may be explained by multicollinearity between different food groups of the MD. Both fruit and whole grains are major factors of the MD plant-based compartment, contributing dietary fiber and polyphenols[ 57 ], and both have been negatively associated with colorectal inflammation and neoplasia[ 12 , 58 , 59 ]. Other MD factors, distributed similarly between cases and controls, were vegetables and legumes, nuts and seeds, poultry and alcoholic beverages.…”

Section: Discussionmentioning

confidence: 99%

Mediterranean dietary components are inversely associated with advanced colorectal polyps: A case-control study

Fliss-Isakov¹,

Kariv²,

Webb³

et al. 2018

WJG

View full text Add to dashboard Cite

AIMTo evaluate the association between the Mediterranean diet (MD) pattern and its components, and advanced colorectal polyps (adenoma and serrated adenoma).METHODSA case-control study among patients undergoing screening, diagnostic or surveillance colonoscopies during 2010-2015 at the Tel-Aviv Medical Center, Gastroenterology Department. Cases with advanced polyps were defined as: Advanced adenoma [> 10 mm, with features of high grade dysplasia (HGD) or villous histology], advanced serrated adenoma (> 10 mm or with dysplasia) or multiple (≥ 3) non-advanced adenomas or serrated adenomas. Cases of non-advanced adenomas were defined as adenomas < 10 mm, without features of HGD or villous histology. Controls were defined as those without polyps at the current colonoscopy and without a history of colorectal polyps. Data collection included: anthropometrics measured according to a standardized protocol, fasting blood tests performed at the same lab, medical history recorded by a structured interview and dietary intake evaluated by a 116-item food frequency questionnaire. Adherence to the MD components was evaluated according to intake above/below the sample median, for potentially beneficial/detrimental components respectively, as accepted.RESULTSWe recruited 206 cases with advanced polyps, 192 cases with non-advanced adenoma and 385 controls. The number of adhered MD components was inversely associated with a diagnosis of advanced polyps in a dose-response manner (OR = 0.34, 95%CI: 0.17-0.65; OR = 0.22, 95%CI: 0.11-0.43; and OR = 0.18, 95%CI: 0.07-0.47 for 3-4, 5-7 and 8-10 components, respectively), but not with non-advanced adenomas (OR = 0.54, 95%CI: 0.25-1.13; OR = 0.48, 95%CI: 0.23-0.99; and OR = 0.43, 95%CI: 0.16-1.12 for 3-4, 5-7 and 8-10 components, respectively). Low intake of sugar-sweetened beverages and red meat, as well as high intake of fish, were inversely associated with advanced polyps (OR = 0.56, 95%CI: 0.36-0.87; OR = 0.63, 95%CI: 0.42-0.95; and OR = 0.66, 95%CI: 0.44-0.99, respectively), while only low intake of red meat was inversely associated with non-advanced adenomas (OR = 0.71, 95%CI: 0.49-0.97).CONCLUSIONA better adherence to the MD, specifically low intake of sugar-sweetened beverages and red meat as well as high intake of fish, is related to lower odds for advanced polyps.

show abstract

“…The current FDA-approved medical recommendation for patients diagnosed with NAFLD is low-fat, fruit and vegetables-based diet and regular physical activity [ 4 , 13 , 14 , 15 ]. Indeed, dietary polyphenols, a large and heterogeneous group of phytochemicals in herbs and plant-based foods, have been associated with lower risk of NAFLD [ 16 , 17 ]. In particular, Citrus flavonoids have been shown to exert several positive health effects on glucose and lipid metabolism in experimental models [ 12 , 16 , 18 , 19 , 20 , 21 , 22 ] and humans [ 23 , 24 , 25 ].…”

Section: Introductionmentioning

confidence: 99%

Bergamot Polyphenols Boost Therapeutic Effects of the Diet on Non-Alcoholic Steatohepatitis (NASH) Induced by “Junk Food”: Evidence for Anti-Inflammatory Activity

et al. 2018

View full text Add to dashboard Cite

Wrong alimentary behaviors and so-called “junk food” are a driving force for the rising incidence of non-alcoholic fatty liver disease (NAFLD) among children and adults. The “junk food” toxicity can be studied in “cafeteria” (CAF) diet animal model. Young rats exposed to CAF diet become obese and rapidly develop NAFLD. We have previously showed that bergamot (Citrus bergamia Risso et Poiteau) flavonoids, in the form of bergamot polyphenol fraction (BPF), effectively prevent CAF diet-induced NAFLD in rats. Here, we addressed if BPF can accelerate therapeutic effects of weight loss induced by a normocaloric standard chow (SC) diet. 21 rats fed with CAF diet for 16 weeks to induce NAFLD with inflammatory features (NASH) were divided into three groups. Two groups were switched to SC diet supplemented or not with BPF (CAF/SC±BPF), while one group continued with CAF diet (CAF/CAF) for 10 weeks. BPF had no effect on SC diet-induced weight loss, but it accelerated hepatic lipid droplets clearance and reduced blood triglycerides. Accordingly, BPF improved insulin sensitivity, but had little effect on leptin levels. Interestingly, the inflammatory parameters were still elevated in CAF/SC livers compared to CAF/CAF group after 10 weeks of dietary intervention, despite over 90% hepatic fat reduction. In contrast, BPF supplementation decreased hepatic inflammation by reducing interleukin 6 (Il6) mRNA expression and increasing anti-inflammatory Il10, which correlated with fewer Kupffer cells and lower inflammatory foci score in CAF/SC+BPF livers compared to CAF/SC group. These data indicate that BPF mediates a specific anti-inflammatory activity in livers recovering from NASH, while it boosts lipid-lowering and anti-diabetic effects of the dietary intervention.

show abstract

Polyphenols treatment in patients with nonalcoholic fatty liver disease

Cited by 42 publications

References 28 publications

Effects of Antioxidants in Reducing Accumulation of Fat in Hepatocyte

Effects of Antioxidants in Reducing Accumulation of Fat in Hepatocyte

Mediterranean dietary components are inversely associated with advanced colorectal polyps: A case-control study

Bergamot Polyphenols Boost Therapeutic Effects of the Diet on Non-Alcoholic Steatohepatitis (NASH) Induced by “Junk Food”: Evidence for Anti-Inflammatory Activity

Contact Info

Product

Resources

About