Polyphenols as Emerging Antimicrobial Agents

Ali, Arshad; Parisi, Antonio; Normanno, G.

doi:10.1007/978-3-030-84126-3_10

Cited by 3 publications

(1 citation statement)

References 281 publications

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“…TFC and TPC are also reported to prevent DNA from oxidative stress including inhibition of tumor cell growth and exhibit antimicrobial and anti-inflammatory activities. The previous investigations also revealed the role of phenolic compounds as a great source of antioxidant activity in D. malabarica [ 50 ], and the flavonoids are polyphenols which play a vital role in antibiotics action [ 51 ] because only flavonoids are involved in making complexes with microbial proteins, cell wall, and many other components that are responsible for biological function.…”

Section: Resultsmentioning

confidence: 99%

A Comparative Study of Diospyros malabarica (Gaub) Extracts in Various Polarity-Dependent Solvents for Evaluation of Phytoconstituents and Biological Activities

Zreen

Hameed

Kiran

et al. 2022

BioMed Research International

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Keeping in mind the ascribed repute of Diospyros malabarica (D. malabarica), this investigation was commenced to assess the effect of diverse solvents on extraction yields, phytochemical components and antioxidant capability, and in vitro biological activities of D. malabarica for pharmaceutically active constituents to combat various infections. To screen phytochemicals both qualitatively (flavonoids, terpenoid, saponins, tannins) and quantitatively like total phenolic and flavonoid contents, Diospyros malabarica parts include the following: root, leaves, bark, stem, ripe, and unripe fruit were sequentially extracted with organic solvents such as petroleum ether, dichloromethane, ethyl acetate, ethanol, methanol, and water in increasing order of polarity from less polar to more polar solvents. Furthermore, biological activities such as antibacterial, antifungal, anticancer, antidiabetic, and anti-inflammatory were explored. The results revealed that all the tested solvents displayed a vital role in the extraction yield, the content of phytochemicals, and the studied biological activities. Methanol was found as the best solvent followed by the ethanol for the extraction, representing the highest extraction yield (18.3%), rich diversity of phytochemicals, and the highest total phenolic contents ( 602 ± 0.001 μ g EAG/mg of extract) and total flavonoid contents ( 455 ± 0.6 μ g EQ/mg of extract) in bark extract. Furthermore, methanol bark extract showed high in vitro antibacterial activity ( 30.25 mm ± 0.9 ), antifungal activity ( 18.25 mm ± 0.2 ), anticancer activity (48%), antidiabetic activity (68%) and anti-inflammatory activity (62%) followed by ethanol amongst other extracts of D. malabarica. Accordingly, methanol might be as an ideal solvent to get maximum content of phytochemicals, promising antioxidants, and in vitro biological activities from bark extract amongst other extracts of D. malabarica compared to pet ether, ethyl acetate, and dichloromethane and may act as free radical rummager because phytochemical constituents exhibit antioxidant capability. Our findings suggest that phytochemical compounds (flavonoids, tannins, phenols, saponins, and terpenoids) found in the bark extract of D. malabarica may be attributed to evaluate potent anti-inflammatory, anticancer, antidiabetic, antibacterial, and antifungal activities.

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Section: Resultsmentioning

confidence: 99%

A Comparative Study of Diospyros malabarica (Gaub) Extracts in Various Polarity-Dependent Solvents for Evaluation of Phytoconstituents and Biological Activities

Zreen

Hameed

Kiran

et al. 2022

BioMed Research International

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Valorization and structural characterization of onion peel powder for the development of functional bread

Ateeq,

Shabir Ahmad,

Imran

et al. 2023

International Journal of Food Properties

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Role and mechanism of fruit waste polyphenols in diabetes management

et al. 2023

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Among various diseases in humans, diabetes is one of the most complicated disorders resulting either from the malfunctioning of β cells, causing a poor discharge of insulin from them, or poor functioning of the liberated insulin. A wide array of chemical compounds so-called secondary metabolites are present in plants. These phytochemicals are produced as by-products of metabolism and play a key role in plant protection. However, in humans, they offer several beneficial functions. Polyphenols are an important class of phytochemicals and apart from fruits, they are also found in their major wastes mainly including the peel, pomace, and seed. The current review is aimed to focus on the potential sources, distribution, and extraction/isolation of polyphenols from major fruit wastes along with highlighting their medicinal and therapeutic benefits, especially in the management of diabetes.

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Polyphenols as Emerging Antimicrobial Agents

Cited by 3 publications

References 281 publications

A Comparative Study of Diospyros malabarica (Gaub) Extracts in Various Polarity-Dependent Solvents for Evaluation of Phytoconstituents and Biological Activities

A Comparative Study of Diospyros malabarica (Gaub) Extracts in Various Polarity-Dependent Solvents for Evaluation of Phytoconstituents and Biological Activities

Valorization and structural characterization of onion peel powder for the development of functional bread

Role and mechanism of fruit waste polyphenols in diabetes management

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