Polyphenol treatments increase elastin and collagen deposition by human dermal fibroblasts; Implications to improve skin health

Chowdhury, Aniqa; Nosoudi, Nasim; Karamched, Saketh; Parasaram, Vaideesh; Vyavahare, Naren

doi:10.1016/j.jdermsci.2021.03.002

Cited by 31 publications

(19 citation statements)

References 21 publications

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“…Furthermore, the collagen fibril in the dermal layers can be stained with the Masson trichrome method, and the abundant production and good organization of collagen are characterized by the thinner and more densely organized collagen bundles [ 11 ]. In the present study, the waving arrangement and deep blue color were illustrated in the normal group ( Figure 4 A).…”

Section: Resultsmentioning

confidence: 99%

“…Consequently, obtaining antioxidative and anti-inflammatory ingredients such as polysaccharides, polyphenols, and protein hydrolysates from natural dietary sources has attracted increasing attention in recent years [ 10 , 11 , 12 , 13 , 14 ]. To date, the excellent performance in scavenging activity of free radicals of some typical edible protein hydrolysates such as corn gluten meal with dairy whey [ 15 ], milk protein hydrolysates [ 16 ], lotus ( Nelumbo nucifera Gaertn ).…”

Section: Introductionmentioning

confidence: 99%

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Theragra chalcogramma Hydrolysates, Rich in Gly-Leu-Pro-Ser-Tyr-Thr, Exerts Anti-Photoaging Potential via Targeting MAPK and NF-κB Pathways in SD Rats

Zhao

Lin

et al. 2022

Marine Drugs

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Previous studies have revealed that excessive exposure to UV irradiation is the main cause of skin photoaging and the signaling pathways of MAPK and NF-κB are involved in this progression. The present study aims to investigate the anti-photoaging effects of low molecular weight hydrolysates from Theragra chalcogramma (TCH) and to clarify the underlying mechanism. The degradation of mechanical barrier functions in photoaged skin was substantially ameliorated after TCH administration; meanwhile, TCH significantly elevated the antioxidant capacity and suppressed the over-production of inflammatory cytokine IL-1β. Moreover, the histopathological deteriorations such as epidermal hyperplasia and dermal loss were significantly alleviated, along with the increase in procollagen type I content and decrease in MMP-1 activity (p < 0.05). Furthermore, TCH effectively blocked the MAPK and NF-κB signaling pathways through inhibition of the phosphorylation of p38, JNK, ERK, iκB, and p65 proteins. Collectively, these data indicate that TCH has potential as a novel ingredient for the development of anti-photoaging foods.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Theragra chalcogramma Hydrolysates, Rich in Gly-Leu-Pro-Ser-Tyr-Thr, Exerts Anti-Photoaging Potential via Targeting MAPK and NF-κB Pathways in SD Rats

Zhao

Lin

et al. 2022

Marine Drugs

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“…Extract of Foeniculum vulgare (FV) significantly increased the production of collagen and elastin, showing dose-dependent decrease in production of reactive oxygen species (ROS) but increase in the expression of cytoprotective antioxidants such as glutathione, and significantly quenching UVB-induced phosphorylation of extracellular regulated protein kinases (ERK) and p38 mitogen-activated protein kinase (MAPK) in normal human skin fibroblasts 30 . Polyphenols in combination with short exposure to UVA increased extracellular matrix deposition of elastin and collagen and improved skin properties 31 , 32 . Present study shows that GCG, like EGCG, significantly suppressed the UVB-induced decrease in collagen fibers, compared to NC (Table 1 ), suggesting that GCG protected skin from UVB-induced photoaging via improving collagen functions.…”

Section: Discussionmentioning

confidence: 99%

“…However, these two indicators in ML and HL were lower than NC though they were higher than BC (Table 1 ), suggesting that GCG had no effects on prevention of skin oil and moisture loss. The human sebum, which is responsible for oily skin, is reported to exert a photoprotective effect and an increase in the sebum secretion contributed to an augmentation in the skin softness and elasticity 32 – 34 . The oil levels in the UVB irradiated skins including those treated by sunscreen lotion and GCG were increased significantly (Table 1 ).…”

Section: Discussionmentioning

confidence: 99%

Protective effects of gallocatechin gallate against ultraviolet B induced skin damages in hairless mice

Sheng

Xiang

et al. 2022

Sci Rep

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Epigallocatechin gallate (EGCG) has the effect to protect skin from ultraviolet B (UVB) induced damages, but it is unstable under ambient conditions, being susceptible to become brown in color. Gallocatechin gallate (GCG), an epimer counterpart of EGCG, is more stable chemically than EGCG. The potential effects of GCG against UVB-induced skin damages has not been available. The objective of this study was to investigate the protective effects of GCG against UVB-induced skin photodamages. GCG was topically applied on the skin of hairless mice at three dosage levels (LL, 12.5 mg/mL; ML 25 mg/mL; HL, 50 mg/mL), with EGCG and a commercially available baby sunscreen lotion SPF50 PA+++ as control. The mice were then irradiated by UVB (fluence rate 1.7 µmol/m2 s) for 45 min. The treatments were carried out once a day for 6 consecutive days. Skin measurements and histological studies were performed at the end of experiment. The results show that GCG treatments at ML and HL levels inhibited the increase in levels of skin oil and pigmentation induced by UVB irradiation, and improved the skin elasticity and collagen fibers. GCG at ML and HL levels inhibited the formation of melanosomes and aberrations in mitochondria of UVB-irradiated skin in hairless mice. It is concluded that GCG protected skin from UVB-induced photodamages by improving skin elasticity and collagen fibers, and inhibiting aberrations in mitochondria and formation of melanosomes.

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“…Several polyphenols like resveratrol, curcumin, catechins, and procyanidins have anti-diabetic properties. There are evidences that certain polyphenols have the potential to treat not only the viral infection [36], but also slow down the aging process [37][38][39]. More studies need to be done to evaluate the potential of polyphenols to treat the COVID-19, but polyphenols may offer multiple potential agents that can be explored to prevent and treat the viral infection.…”

Section: Polyphenolsmentioning

confidence: 99%

Aging and diabetes drive the COVID-19 forwards; unveiling nature and existing therapies for the treatment

2021

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Human SARS Coronavirus-2 (SARS-CoV-2) has infected more than 170 million people worldwide and resulted in more than 3.5 million deaths so far. The infection causes Coronavirus disease in people of all age groups, notably diabetic and old age people, at a higher risk of infectivity and fatality. Around 35% of the patients who have died of the disease were diabetic. The infection is associated with weakening immune response, chronic inflammation, and potential direct pancreatic impairment. There seems to be a three-way association of the SARS-CoV-2 infection with diabetes and aging. The COVID-19 infection causes metabolism complications, which may induce diabetes and accelerate aging in healthy individuals. How does diabetes elevate the likelihood of the infection is not clearly understood. we summarize mechanisms of accelerated aging in COVID-19 and diabetes, and the possible correlation of these three diseases. Various drug candidates under different stages of pre-clinical or clinical developments give us hope for the development of COVID-19 therapeutics, but there is no approved drug so far to treat this disease. Here, we explored the potential of anti-diabetic and anti-aging natural compounds for the COVID-19 treatment. We have also reviewed different therapeutic strategies with plant-based natural products that may be used to cure patients infected with SARS-CoV-2 and post-infection syndrome.

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Polyphenol treatments increase elastin and collagen deposition by human dermal fibroblasts; Implications to improve skin health

Cited by 31 publications

References 21 publications

Theragra chalcogramma Hydrolysates, Rich in Gly-Leu-Pro-Ser-Tyr-Thr, Exerts Anti-Photoaging Potential via Targeting MAPK and NF-κB Pathways in SD Rats

Theragra chalcogramma Hydrolysates, Rich in Gly-Leu-Pro-Ser-Tyr-Thr, Exerts Anti-Photoaging Potential via Targeting MAPK and NF-κB Pathways in SD Rats

Protective effects of gallocatechin gallate against ultraviolet B induced skin damages in hairless mice

Aging and diabetes drive the COVID-19 forwards; unveiling nature and existing therapies for the treatment

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